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ABIOMED, Inc. engages in the development, manufacture, and marketing of medical products to assist or replace the pumping function of the failing heart. ABIOMED manufactures and sells the AB5000 Circulatory Support System and the BVS 5000 Biventricular Support System for the temporary support of patients with failing but potentially recoverable hearts. BVS and AB5000 are sold in the United States through direct sales and clinical support teams. In Europe, ABIOMED offers the Impella Recover minimally invasive cardiovascular support systems. Its AbioCor, which is in clinical trials, is a heart replacement device for the failing ventricles of a patient's diseased heart and takes over the heart's blood pumping function. ABIOMED conducts its international sales efforts through distributors and by selling directly in selected European markets through ABIOMED B.V., its wholly owned subsidiary. The company was founded by David M. Lederman in 1981. ABIOMED is headquartered in Danvers, Massachusetts.
ACME UNITED CORPORATION (ACU)
Acme United Corporation engages in the manufacture and sale of cutting devices, measuring instruments, and safety products for school, office, and home use in the United States, Canada, Europe, and Asia. It sells scissors, shears, guillotine paper trimmers, rotary paper trimmers, rotary cutters, hobby knives and blades, utility knives, medical cutting instruments, rulers, math tools, tape measures, first aid kits, personal protection products, and over-the-counter medication refills. The company sells its products through independent manufacturer representatives and direct sales force to wholesale, contract, and retail stationery distributors, office supply super stores, school supply distributors, and mass market retailers. Acme United was organized in 1867. It changed its name to The Acme Shear Company in 1882 and to Acme United Corporation in 1971. The company is headquartered in Fairfield, Connecticut.
AMERICAN DENTAL PARTNERS INC (ADPI)
American Dental Partners, Inc. provides business services to multidisciplinary dental groups in selected markets in the United States. It acquires selected assets of the dental practices with which it affiliates and enters into long-term service agreements with the affiliated dental groups or professional corporations. The company provides various services for the administration of the nonclinical aspects of the dental operations. These services include assisting with organizational planning and development; providing recruiting, retention, and training programs; supporting quality assurance initiatives of the affiliated dental group; providing ongoing facilities development, maintenance, and management; administering employee benefits and payroll; procuring supplies and other resources; maintaining necessary information systems; assisting with marketing and payor relations; and providing financial planning, reporting, and analysis. As of December 31, 2004, American Dental Partners was affiliated with 19 dental group practices, comprising 398 dentists practicing in 177 locations in 17 states. The company was founded by Gregory A. Serrao in 1995 and is based in Wakefield, Massachusetts.
Aetna, Inc. provides health care, dental, pharmacy, group life, disability, and long-term care benefits in the United States. It operates in three segments: Health Care, Group Insurance, and Large Case Pensions. Health Care segment consists of health and dental plans offered on a risk basis and on an employer-funded basis. It provides medical and dental benefit products, including health maintenance organization, point-of-service, preferred provider organization, and indemnity benefit products. These products are also sold with the company's consumer-directed health plans, Aetna HealthFund and Health Savings Accounts. It also provides specialty products, such as pharmacy benefits management, dental, vision, and behavioral health programs. Further, this segment provides access to network of independent dental and vision participating providers through its Vital Savings by Aetna discount program. Group Insurance segment offers life, disability, and long-term care insurance products. Large Case Pension segment manages a variety of retirement products, including pension and annuity products primarily for defined benefit and defined contribution plans. The company was incorporated in 1982 under the name of United States Health Care Systems, Inc. and subsequently changed its name to Aetna, Inc. Aetna is headquartered in Hartford, Connecticut.
Almost Family, Inc. and its subsidiaries provide home health nursing and adult day health services. The company operates in two segments, Home Health Care and Adult Day Care. The Home Health Care segment includes two divisions, Visiting Nurse (VN) and Personal Care (PC). The VN division provides skilled medical services in patients'' homes to enable recipients to reduce or avoid periods of hospitalization and/or nursing home care. The PC division provides services in patients'' homes through a para-professional staff, such as home health aides. The company's Adult Day Health Services segment provides health services to disabled or frail adults. These services are provided in the company''s physical facilities. The company operates 20 adult day care centers, as of December 31, 2004. Almost Family has service locations in Kentucky, Florida, Maryland, Ohio, Connecticut, Massachusetts, Alabama, and Indiana. The company was incorporated in 1985. It was formerly known as Caretenders HealthCorp and changed its name to Almost Family, Inc. in 2000. The company is based in Louisville, Kentucky.
APRIA HEALTHCARE GROUP INC (AHG)
Apria Healthcare Group, Inc. provides home healthcare services, and related products and supplies as part of a care plan. It operates in three segments: Home Respiratory Therapy, Home Infusion Therapy, and Home Medical Equipment/Other. Home Respiratory Therapy segment provides home respiratory therapy services to patients with chronic obstructive pulmonary diseases, nervous system-related respiratory conditions, obstructive sleep apnea, congestive heart failure, and lung cancer. It provides oxygen systems, home ventilators, sleep apnea equipment, nebulizers, respiratory medications, and related services. This segment also offers infant apnea monitors, continuous positive airway pressure devices, and noninvasive positive pressure ventilation. Home Infusion Therapy segment offers infusion therapy services, including the administration of drugs or nutrients directly into the body intravenously through a needle or catheter. It also administers enteral nutrients directly into the gastrointestinal tract through a feeding tube. Home Medical Equipment/Other segment provides patient safety items, ambulatory aids, and in-home equipment, such as wheelchairs and hospital beds. The company also offers other services, such as educating patients and their care-givers about illnesses and providing them with written instructions about home safety, self-care, and the proper use of their equipment; monitoring patients' individualized treatment plans; reporting patient progress and status to the physician and/or managed care organization; providing in-home delivery and set-up of equipment and/or supplies; maintaining and repairing equipment; and processing claims to third-party payors and billing and collecting patient co-pays and deductibles. The company offers its services primarily to physicians, managed care organizations, hospitals, medical groups, home health agencies, and case managers in the United States. Apria Healthcare Group is headquartered in Lake Forest, California.
ALLIED HEALTHCARE PRODUCTS INC (AHPI)
Allied Healthcare Products, Inc. manufactures respiratory care products, medical gas equipment, and emergency medical products used in various hospital and alternate care settings. Its respiratory care product line includes respiratory care/anesthesia products, including air compressors, calibration equipment, humidifiers, croup tents, equipment dryers, and respiratory disposable products; and home respiratory care products, including aluminum oxygen cylinders, oxygen regulators, pneumatic nebulizers, and portable suction equipment. The company's medical gas equipment product line includes construction products, such as in-wall medical system components, central station pumps and compressors, and headwalls; regulation devices and suction equipment, such as flowmeters, vacuum regulators, and pressure regulators, as well as related adapters, fittings, and hoses that measure, regulate, monitor, and enable transfer of medical gases from walled piping or equipment to patients in hospital rooms, operating theaters, or intensive care areas; and disposable oxygen and gas cylinders. Its emergency medical product line includes respiratory/resuscitator products, including demand resuscitation valves, portable resuscitation systems, bag masks and related products, emergency transport ventilators, precision oxygen regulators, minilators, multilators, and humidifiers; and trauma patient handling products, including spine immobilization products, pneumatic anti-shock garments, and trauma burn kits. Allied Healthcare sells its products to respiratory care/anesthesia product distributors, hospital construction contractors, emergency medical equipment dealers, and hospitals. The company markets its products through dealers, agents, and exporters in the United States, Canada, Mexico, central and South America, Europe, the Middle East, and the Far East. Allied Healthcare was founded in 1979 and is headquartered in St. Louis, Missouri.
AMERICAN MEDICAL SYSTEMS HOLDINGS INC (AMMD)
American Medical Systems Holdings, Inc. (AMS) engages in the development and delivery of medical solutions to patients and physicians. The company offers products for erectile restoration, benign prostatic hyperplasia, male urethral stricture, urinary and fecal incontinence, menorrhagia, and pelvic organ prolapse. It provides various solutions, including the Artificial Urinary Sphincter, the In-Fast, SPARC, Monarc, BioArc sling systems, and the Acticon Neosphincter to restore male and female urinary continence and fecal continence, as well as provides treatments for vaginal prolapse and menorrhagia. In addition, AMS offers a range of solutions for erectile restoration and urethral stricture; TherMatrx Dose Optimized therapy for in-office benign prostatic hyperplasia, as well as provides detrusor external sphincter dyssynergia treatment and prostate treatments. The company distributes its products through direct sales force, independent sales representatives, and independent distributors to physician customers, including urologists, gynecologists, and urogynecologists in the United States, Canada, Australia, Brazil, Europe, Europe, and Asia. AMS was founded by Robert Buuck, Gerald Timm, William Bradley, and F. Brantley Scott in 1972. The company is headquartered in Minnetonka, Minnesota.
AMERICAN SHARED HOSPITAL SERVICES (AMS)
American Shared Hospital Services, through its subsidiary, provides Gamma Knife stereotactic radiosurgery services to medical centers in the United States. The Gamma Knife, an alternative noninvasive procedure to conventional brain surgery, treats selected malignant tumors, benign brain tumors, arteriovenous malformations, and trigeminal neuralgia. The company also offers planning, installation, reimbursement, and marketing support services. As of April 28, 2005, it provided Gamma Knife units to 20 medical centers in Arkansas, California, Connecticut, Florida, Illinois, Maryland, Massachusetts, Mississippi, Nevada, New Jersey, New Mexico, New York, Ohio, Pennsylvania, Texas, and Wisconsin. American Shared Hospital was founded by Ernest A. Bates in 1980 and is based in San Francisco, California.
ANGEION CORPORATION (ANGN)
Angeion Corporation, through its subsidiary, Medical Graphics Corporation, engages in the development, manufacture, and marketing of noninvasive cardio-respiratory diagnostic systems used in the management and improvement of cardio-respiratory health. The company offers its products to health care professionals for the prevention, detection, and treatment of heart and lung disease. Its MedGraphics products include pulmonary function and cardiopulmonary exercise testing systems that operate with its proprietary BreezeSuite Windows2000/XP software to address the needs of hospitals, clinics, and physician offices. Angeion's pulmonary function systems consist of spirometry, pulmonary function systems, and body plethysmograph systems. In addition, it provides cardiopulmonary exercise testing systems, which measure functional capacity, fitness, or conditioning levels, as well as enable physicians to diagnose heart and lung diseases. Further, the company offers cycle ergometers and treadmills for use in diagnostic, rehabilitation, training, and sports medicine applications. Angeion markets its products in the United States through direct sales force, as well as through independent distributors internationally. It also sells health and fitness products through health and fitness clubs, personal training studios, weight loss centers, and other retail outlets. The company was founded in 1992 and is headquartered in Saint Paul, Minnesota.
APA ENTERPRISES INC (APAT)
APA Enterprises, Inc. engages in the development, design, manufacture, and marketing of fiber optics, copper, and gallium nitride-based components and devices for industrial, commercial, consumer, and scientific applications. It operates in two segments, Optronics, and Cables and Networks. The Optronics segment offers ultraviolet measurement instruments for consumers and industrial customers, and gallium nitride-based transistors for power amplifiers and other commercial applications. The Cables and Networks segment designs and manufactures fiber optic connectivity solutions centered upon its fiber distribution system (FDS). The FDS product line supports various panel configurations, densities, connectors, and adapter options. This segment offers fiber distribution central office frame systems, fiber distribution outside plant cabinets, optical components, and cable assemblies. APA Enterprises distributes its products through direct sales force and manufacturer representative organizations. The company was founded in 1979 by Anil K. Jain. It was formerly known as APA Optics, Inc. and changed its name to APA Enterprises, Inc. in 2004. APA Enterprises is headquartered in Blaine, Minnesota.
Alpha Pro Tech, Ltd. engages in the development, manufacture, and marketing of disposable protective apparel and infection control products primarily in the United States. It also manufactures and distributes medical bed pads and accessories, as well as pet beds. The company operates in four segments: Disposable Protective Apparel, Infection Control, Extended Care, and Engineered Products. The Disposable Protective Apparel segment produces disposable protective apparel, which include shoecovers, bouffant caps, gowns, frocks, coveralls, and lab coats. The Infection Control segment offers face masks and eye shields. The Extended Care segment offers extended care products, such as medical bed pads, pet beds and pet toy accessories, wheelchair covers, geriatric chair surfaces, operating room table surfaces, and pediatric surfaces. The Engineered Products segment provides a line of construction weatherization products and paint with antimicrobials. Its construction weatherization products consist of building wrap and a synthetic roof underlayment. Its line of paint with antimicrobials is designed to inhibit growth of bacteria, fungi, and algae on the painted surfaces in hospitals, surgical rooms, and cleanrooms and associated controlled environments. Alpha Pro Tech offers its products in the industrial, cleanroom, pharmaceutical, medical and dental, and extended care markets. The company sells its products primarily through a network of independent distributors. Alpha Pro Tech was founded in 1983 and is headquartered in Markham, Canada.
ARRAY BIOPHARMA INC (ARRY)
Array BioPharma, Inc., a biopharmaceutical company, engages in the discovery, development, and commercialization of small molecule drugs to treat debilitating and life-threatening diseases. The company's drug development pipeline primarily focuses on the treatment of cancer and inflammatory disease, and includes drugs that regulate targets in therapeutically important disease pathways. It offers ARRY-142886 (AZD6244)/MEK, which is in the Phase Ib clinical development, for the treatment of cancer. The company also provides ARRY-334543, ErbB-2/EGFR Inhibitors, and ErbB-2 Inhibitors that are in preclinical models of human cancer. It has collaborations with Amgen; AstraZeneca; Elan; Eli Lilly and Company; Genentech, Inc.; Hoffman-La Roche, Inc.; ICOS Corporation; InterMune, Inc.; Japan Tobacco, Inc.; Procter & Gamble Pharmaceuticals; QLT, Inc.; Ono Pharmaceutical Co., Ltd.; and Takeda Pharmaceutical Company, Ltd. Array was founded in 1998 and is headquartered in Boulder, Colorado.
ARTHROCARE CORPORATION (ARTC)
Arthrocare Corporation engages in the design, development, manufacture, and marketing of medical devices used in soft-tissue surgery. Its products are based on its patented Coblation technology, a soft-tissue surgical controlled ablation technology. The company operates through five segments: Sports Medicine, Arthrocare Spine, ENT, Arthrocare Coblation Technologies (ACT), and AngioCare. The Sports Medicine segment offers surgical instruments for use in various arthroscopic procedures, such as shoulder, knee, elbow, ankle, wrist, hip, and nontraumatic soft tissue injuries. The ArthroCare Spine segment provides procedures for spinal disc decompression and soft tissue removal, as well as bone access and biopsy, and percutaneous injection of bone cement and bone augmentation in the spine. The ENT segment commercializes its ear, nose, and throat surgery products for use in general head, neck, and oral surgical procedures, which include sinus surgery, the treatment of snoring, reduction of nasal turbinates, adenoidectomy, and tonsillectomy. It also provides Visage products for use in various cosmetic surgery procedures. The ACT segment develops and manufactures products as an original equipment manufacture supplier of surgical instruments to companies in general surgery, cardiology, urology, and gynecology markets. The AngioCare segment develops various cardiovascular applications. These products enable surgeons to ablate, shrink, sculpt, cut, or aspirate, and suction soft tissue, as well as to seal small bleeding vessels with one surgical system. The company sells its products through a combination of distributors supported by regional sales mangers, a direct sales force, and corporate partners in the United States and Europe, as well as in Japan. It also distributes through relationships with distributors of arthroscopy products in Europe, South Africa, South and Central America, and Russia. ArthroCare was founded in 1993 and is headquartered in Austin, Texas.
AMERICA SERVICE GROUP INC (ASGR)
America Service Group, Inc. and its subsidiaries provide managed healthcare services to correctional facilities in the United States. It contracts with state, county, and local governmental agencies to provide and administer healthcare services to inmates of prisons and jails. The company also administers various on-site healthcare programs, and arranges for and oversees off-site hospitalization and specialty outpatient care. Its services include on-site services, such as regular physical and dental screening and care, psychiatric care, OB-GYN screening and care, and diagnostic testing; and off-site services comprising specialty outpatient diagnostic testing and care, emergency room care, surgery, and hospitalization. The company also provides on-site administrative support services, including program management, maintenance of on-site medical records and employee recruitment, scheduling, continuing education and quality assurance, medical audits, credentialing, and clinical program development activities. In addition, it distributes pharmaceuticals and medical supplies to inmates of correctional facilities; and provides clinical pharmacy services. The company was founded in 1978 and is headquartered in Brentwood, Tennessee.
ASPECT MEDICAL SYSTEMS INC (ASPM)
Aspect Medical Systems, Inc. and its subsidiaries engage in the development, manufacture, and marketing of an anesthesia monitoring system called the BIS system. The company's BIS system provides information that enables clinicians to assess and manage a patient's level of consciousness in the operating room and intensive care settings, and administer the amount of anesthesia needed by each patient. Its customers include anesthesia providers, hospitals, outpatient surgical centers, and individual practitioners in office-based practice. The company markets and sells its products through direct sales force, distributors, and original equipment manufacturers worldwide. Aspect Medical Systems has collaboration with Brain Resource Co., Ltd. in a clinical study that would evaluate brain electrical activity in patients identified with mild cognitive impairment, a memory impairment that often precedes Alzheimer's disease. The company was founded in 1987 and is headquartered in Newton, Massachusetts.
ATRION CORPORATION (ATRI)
Atrion Corporation engages in the design, development, manufacture, marketing, sale, and distribution of various products and components, primarily for the medical and health care industry worldwide. It offers ophthalmology products, which include LacriCATH product line of balloon catheters used in the treatment of nasolacrimal duct obstruction in children and adults. The company's cardiovascular products comprise MPS Myocardial Protection System that delivers essential fluids and medications to the heart during open-heart surgery; cardiac surgery vacuum relief valves; Retract-O-Tape silicone vessel loops; and Clean-Cut rotating aortic punch, used in heart bypass surgery. It also offers intravenous fluid delivery line for therapy procedures employed in anesthesia administration, intravenous feeding, intensive care, and cancer therapy. Atrion manufactures valves, tubing flanges, right angle connectors, and closures for life vests, life rafts, inflatable boats, inflatable toys, survival equipment, and other inflatable structures, as well as various one-way and two-way 'Breather' valves for use on electronics cases, munitions cases, pressure vessels, lift bags, space suits, mattresses, escape slides, and other application requiring pressure relief for use in aviation and marine safety products. In addition, the company provides contract manufacturing services for other original equipment manufacturers of medical devices, as well as warehousing and inventory management services. It offers pressure monitoring kits for use in labor and delivery procedures and various critical care applications. Further, the company owns and maintains a 22-mile high-pressure steel pipeline in north Alabama that is leased to an industrial gas producer that transports gaseous oxygen. Atrion markets its components to other equipment manufacturers; and sells finished devices to physicians, hospitals, clinics, and other treatment centers. The company is headquartered in Dallas, Texas.
ATS Medical, Inc. engages in the development, manufacture, and marketing of medical devices, primarily cardiovascular surgery products. It operates in the mechanical bileaflet portion of the replacement heart valve and in the surgical treatment of atrial fibrillation markets. The company also develops autotransfusion products. ATS Medical's primary product includes ATS Open Pivot Heart Valve, which is designed to address factors that contribute to thrombogenesis in mechanical valves and enable hemodynamic performance. The company also markets surgical cryotherapy products for the ablation of cardiac arrhythmias in the United States and internationally. It sells its products through direct sales organizations in the United States and France, as well as through an independent distribution network in other international markets. ATS Medical was founded in 1987 and is based in Minneapolis, Minnesota.
AVENTINE RENEWABLE ENERGY HOLDINGS INC (AVR)
Aventine Renewable Energy Holdings, Inc. engages in the production and marketing of fuel-grade ethanol in the United States. It also produces various co-products, such as distillers grain, corn gluten feed, corn germ, and brewers' yeast. In addition, the company produces bio-products, Kosher and Chametz free brewers' yeast, which is used in animal and human food and fermentation applications. Aventine Renewable Energy Holdings is headquartered in Pekin, Illinois.
BAXTER INTERNATIONAL INC (BAX)
Baxter International, Inc., through its subsidiaries, assists healthcare professionals and their patients with the treatment of complex medical conditions, including cancer, hemophilia, immune disorders, kidney disease, and trauma worldwide. The company operates in three segments: Medication Delivery, BioScience, and Renal. The Medication Delivery segment provides various intravenous solutions and specialty products that are used in combination for fluid replenishment, general anesthesia, nutrition therapy, pain management, antibiotic therapy, and chemotherapy. The BioScience segment develops biopharmaceuticals, biosurgery products, vaccines and blood collection, and processing and storage products and technologies for transfusion therapies. The Renal segment develops products and provides services to treat end-stage kidney disease. The company's products are used by hospitals, clinical and medical research laboratories, blood and plasma collection centers, kidney dialysis centers, rehabilitation centers, nursing homes, doctors' offices, and by patients at home under physician supervision. It distributes its products through independent distributors, drug wholesalers acting as sales agents, and specialty pharmacy or homecare companies. Baxter International has collaborative agreements with Nektar Therapeutics to develop PEGylated therapeutic forms of blood clotting proteins for patients with hemophilia, in order to reduce the frequency of injections required to treat blood clotting disorders, such as hemophilia; and with Lipoxen Technologies, Ltd. to develop longer acting therapeutic forms of blood clotting proteins. The company was founded in 1931 and is based in Deerfield, Illinois.
C. R. Bard, Inc. (Bard) engages in the design, manufacture, packaging, distribution, and sale of medical, surgical, diagnostic, and patient care devices. It has four product groups: Vascular, Urology, Oncology, and Surgical Specialties. In the Vascular products group, the company offers products for the peripheral vascular market. These products include percutaneous transluminal angioplasty catheters, guidewires, introducers and accessories, peripheral stents, vena cava filters, and biopsy devices; electrophysiology products, including diagnostic, therapeutic, and temporary pacing electrode catheters; and fabrics, meshes, and implantable vascular grafts. In the Urology products group, Bard offers foley catheters; surgical sling and injectable tissue bulking products that are used to treat stress urinary incontinence; natural and synthetic materials for the treatment of pelvic floor or vaginal prolapse; brachytherapy services, devices, and radioactive seeds that are used to treat prostate cancer; urine monitoring and collection systems; ureteral stents; and specialty devices for ureteroscopic procedures and stone removal. The company's Oncology products include devices used in the treatment and management of various cancers, and other diseases and disorders. These include specialty access catheters, ports, and enteral feeding devices. Bard's Surgical Specialty products include meshes for hernia and other soft tissue repairs; irrigation devices for orthopedic, laparoscopic, and gynecological procedures; and products for topical hemostasis. It sells its products to hospitals, individual health care professionals, extended care facilities, and alternate site facilities worldwide. Bard distributes its products directly and through distributors. The company was founded in 1907 by Charles Russell Bard and is headquartered in Murray Hill, New Jersey.
BECTON DICKINSON AND COMPANY (BDX)
Becton, Dickinson and Company engages in the manufacture and sale of medical supplies, devices, laboratory equipment, and diagnostic products worldwide. The company has three segments: Medical, Diagnostics, and Biosciences. The Medical segment offers needles, syringes, and intravenous catheters, including safety-engineered devices for medication delivery; insulin injection devices and blood glucose monitors for the treatment of diabetes; prefillable drug delivery devices to pharmaceutical companies and end-users as drug/device combinations; surgical blades and regional anesthesia needles; critical care monitoring devices; ophthalmic surgery devices; sharps disposal containers; and home healthcare products. The Diagnostics segment provides integrated systems for evacuated blood collection, a line of safety-engineered specimen collection products and systems, plated media, automated blood culturing, molecular testing systems for sexually transmitted diseases, microorganism identification and drug susceptibility systems, and manual testing products. The Biosciences segment includes fluorescence activated cell sorters and analyzers, cell imaging systems, monoclonal antibodies and kits, reagent systems for life sciences research, tools to aid in drug discovery and growth of tissue and cells, and diagnostic assays. It serves healthcare institutions, life science researchers, clinical laboratories, industry, and the general public, primarily through independent sales representatives and independent distribution channels. The company was founded in 1897 and is based in Franklin Lakes, New Jersey.
BIOJECT MEDICAL TECHNOLOGIES INC (BJCT)
Bioject Medical Technologies, Inc. engages in the development, manufacture, and distribution of needle-free drug delivery systems. The company's products include Biojector 2000, Drug Reconstitution System, and Vitajet. The Biojector 2000 is an injection system that enables healthcare professionals to deliver measured variable doses of medication through the skin, either intramuscularly or subcutaneously, without a needle. The Drug Reconstitution System allows for the transfer of diluents to reconstitute powdered medications into liquid form and withdrawal of liquid medication into a syringe without the use of a needle. The Vitajet is designed for subcutaneous self-injection of insulin in the home. The company is also developing Iject prefilled device for delivery of its drug to treat a specific condition. It has licensing and/or development agreements with Ares Serono, PATH, and Merial for the development of needle-free injection systems. Bioject Medical was founded in 1985 and is headquartered in Bedminster, New Jersey.
BIOLASE TECHNOLOGY INC (BLTI)
Biolase Technology, Inc., a medical technology company, engages in the design, manufacture, and marketing of advanced dental, cosmetic, and surgical lasers and related products primarily in the United States and internationally. Its products include dental laser systems that allow dentists, periodontists, endodontists, oral surgeons, and other specialists to perform various dental procedures, including cosmetic and surgical applications. The company's laser system products include Waterlase system and Diode system. The Waterlase system uses a patented combination of water and laser to perform dental procedures performed using dental drills, scalpels, and other dental instruments for cutting soft and hard tissue. The Diode laser system uses a semiconductor diode laser to perform soft tissue and cosmetic procedures, including tooth whitening. In addition, the company manufactures and sells accessories and disposables for its laser systems, such as hand pieces, laser tips, and tooth whitening gelkits. Biolase Technology sells its products through its direct sales force and a network of independent distributors. The company was founded in 1984 and is headquartered in San Clemente, California.
BIO-REFERENCE LABORATORIES INC (BRLI)
Bio-Reference Laboratories, Inc. provides clinical laboratory testing services primarily in the greater New York metropolitan area. It laboratory testing services are utilized by healthcare providers for the detection, diagnosis, evaluation, monitoring, and treatment of diseases. The company offers a range of chemical diagnostic tests, including blood and urine analysis, blood chemistry, hematology services, serology, radioimmuno analysis, toxicology pap smears, tissue pathology, and other tissue analysis. It offers its services directly to physicians, hospitals, clinics, correctional, and other health facilities. The company also operates a clinical knowledge management service, which uses customer data from laboratory results, pharmaceutical data, claims data, and other data sources to provide administrative and clinical decision support systems. In addition, it operates a Web-based connectivity portal solution for laboratories and physicians. Bio-Reference Laboratories was founded in 1981. The company is based in Elmwood Park, New Jersey.
BIOSPHERE MEDICAL INC (BSMD)
Biosphere Medical, Inc. operates as a medical device company. It engages in the development, manufacture, and marketing of minimally invasive diagnostic and therapeutic applications based on proprietary bioengineered microsphere technology to treat uterine fibroids, hypervascularized tumors, and vascular malformations. The company's products include Embosphere Microspheres, EmboGold Microspheres, Hepasphere SAP Microspheres, EmboCath Hydrophilic Infusion Catheter, and Segway Hydrophilic Guidewire. Embosphere Microspheres and EmboGold Microspheres are used for the treatment of hypervascularized tumors and arteriovenous malformations. Hepasphere SAP Microspheres are used for treatment of liver cancer. EmboCath Hydrophilic Infusion Catheter and Segway Hydrophilic Guidewire are used in peripheral embolization procedures. BioSphere Medical sells its products primarily in the United States and the European Union, as well as in Canada, Middle East, Africa, South America, and Asia. The company was incorporated in 1993. It was formerly known as BioSepra, Inc. and changed its name to BioSphere Medical, Inc. in 1999. BioSphere Medical is headquartered in Rockland, Massachusetts.
BriteSmile, Inc. engages in the development, distribution, marketing, sale, and leasing of teeth whitening technology, products, systems, and services. The company's operations include the development of teeth whitening processes that are distributed in salon settings known as BriteSmile Professional Teeth Whitening centers (centers). It also offers its products and systems through independent dental offices, known as BriteSmile Professional Teeth Whitening Associated Centers (associated centers). In addition, the company sells BriteSmile brand post-whitening maintenance products, including toothpaste, mouthwash, whitening chewing gum, electric toothbrushes, and whitening pen to consumers in centers, associated centers, and through the Internet. As of March 26, 2005, the company had 15 centers and approximately 5,107 associated centers in operation. BriteSmile is headquartered in Walnut Creek, California.
BOSTON SCIENTIFIC CORPORATION (BSX)
Boston Scientific Corporation engages in the development, manufacture, and marketing of medical devices that are used in interventional medical specialties. The company's products are offered by two groups, Cardiovascular and Endosurgery. The Cardiovascular organization provides products and technologies for use in interventional cardiology, peripheral interventions, vascular surgery, electrophysiology, and neurovascular procedures. The Endosurgery organization provides products and technologies for use in oncology, endoscopy, urology, and gynecology procedures. In addition, the company operates in the neuromodulation market. It provides products for the treatment of auditory disorders and chronic pain. The company's less-invasive medical products are used for enlarging narrowed blood vessels to prevent heart attack and stroke; clearing passages blocked by plaque to restore blood flow; opening obstructions and bringing relief to patients suffering from various forms of cancer; performing biopsies and intravascular ultrasounds; mapping electrical problems in the heart; placing filters to prevent blood clots from reaching the lungs, heart, or brain; treating urological, renal, pulmonary, neurovascular, and gastrointestinal diseases; and modulating nerve activity to treat deafness and chronic pain. The company markets its products through direct sales force, and a network of distributors and dealers. Boston Scientific Corp. has a collaboration agreement with Affinergy, Inc. to investigate new coatings for cardiovascular stents. The company was founded by John E. Abele and Peter M. Nicholas in 1979. Boston Scientific Corp. is headquartered in Natick, Massachusetts.
CBIZ, Inc. provides professional business services to various businesses, individuals, governmental entities, and not-for-profit enterprises in the United States and Canada. It offers services through four practice groups, including financial services, employee services, medical management professionals (MMP), and national practices. The company's financial services group provides accounting, tax, financial advisory, litigation support, valuation, Sarbanes-Oxley 404 consulting, internal audit, fraud detection, and real estate advisory services. Its employee services group offers group health, property and casualty insurance, COBRA/Flex, retirement planning, wealth management, life insurance, human capital management, payroll services, specialty life insurance, and actuarial services. CBIZ's MMP group provides coding and billing, accounts receivable management, and full practice management services. Its national practices group consists of managed networking and hardware services, project management, software solutions, mergers and acquisitions, health care consulting, government relations, and IT consulting. The company was founded in 1987. It was formerly known as Century Business Services, Inc. and changed its name to CBIZ, Inc. in 2005. CBIZ is headquartered in Cleveland, Ohio.
CARDIODYNAMICS INTERNATIONAL CORPORATION (CDIC)
CardioDynamics International Corporation engages in the development, manufacture, and marketing of noninvasive impedance cardiography (ICG) diagnostic and monitoring technologies, and electrodes worldwide. Its patented ICG technology noninvasively monitors the heart's ability to deliver blood to the body. The company operates in two segments, ICG and Electrocardiograph (ECG). The ICG segment develops, manufactures, and sells various devices, including the BioZ ICG Monitor and a noninvasive hemodynamic monitor; BioZ ICG Module a hemodynamic status assessment device; and BioZtect a sensors and cable system, which devices use ICG technology to noninvasively measure the heart's mechanical characteristics by monitoring the heart's ability to deliver blood to the body. It also offers certain other diagnostic, monitoring, and measurement devices to physicians, researchers, and equipment manufacturers. The ICG segment's products are used primarily by physicians to assess, diagnose, and treat cardiovascular diseases. The ECG segment designs, manufactures, and sells electrocardiogram electrodes and related supplies, which are used primarily in electrocardiogram and other diagnostic procedures for cardiology, electrotherapy, sleep testing, neurology, and general purpose diagnostic testing. It sells its products to medical suppliers, facilities, and physicians. CardioDynamics has strategic relationships with GE Medical Systems for the development of a custom plug-in module for the GEMS-IT Solar and DASH series of bedside monitors; and a co-development and original equipment manufacturer agreement with Philips Medical Systems, which combines CardioDynamics' proprietary ICG technology with Philips' diagnostic 12-lead ECG and enable both companies to market the combined ICG/ECG product. The company sells its products through its direct sales force and through a network of distributors. CardioDynamics was incorporated in 1980 and is headquartered in San Diego, California.
CIGNA Corporation, through its subsidiaries, provides employee benefits offered through the workplace in the United States, Asia, and Europe. The company operates in two segments, Health Care, and Disability and Life. The Health Care segment offers various managed care, and indemnity products and services, including dental benefit plans; managed behavioral health care services and employee assistance programs; medical management and utilization management services; pharmacy programs and pharmaceutical fulfillment services; and disability and life insurance products. It also provides disability and life insurance products to employers, multiple employer groups, unions, government-sponsored programs, and other groups. Disability and Life segment provides long- and short-term disability insurance, disability and workers' compensation case management, group life insurance, and accident and specialty insurance products. CIGNA also offers personal accident insurance coverage, which consists primarily of accidental death and dismemberment, and travel accident insurance to employers. In addition, the company offers corporate life insurance products, which include permanent life insurance contracts sold to corporations to provide coverage on the lives of certain of their employees. Its corporate life insurance products include universal life and variable universal life policies. CIGNA also provides individual and group life, accident and health insurance, and health care products primarily in South Korea, Hong Kong, Taiwan, the United Kingdom, and Spain. As of December 31, 2004, CIGNA's medical health maintenance organizations networks included approximately 354,000 physicians and 3,100 hospitals. The company was founded in 1792 and is headquartered in Philadelphia, Pennsylvania.
CELSION CORPORATION (CLN)
Celsion Corporation, a biotechnology company, engages in the development and commercialization of treatment systems for cancer and other diseases using focused heat energy in combination with other therapeutic devices, heat-activated drugs, or heat-activated genes. The company markets Prolieve Thermodilatation system for the treatment of Benign Prostatic Hyperplasia, a chronic condition of enlargement of the prostate common in older men. In addition, it conducts Phase I clinical trials of a treatment for liver cancer, using a combination of ThermoDox, its proprietary encapsulation of doxorubicin, a common cancer-treating drug, in a heat-activated liposome; and Phase I clinical trials of a treatment for prostate cancer, using a combination of ThermoDox and heat from a modified Prolieve device. In addition, it develops gene-based cancer repair inhibitor, which is in late stage preclinical development. Celsion Corporation has a strategic alliance with Boston Scientific Corporation to market Prolieve system. The company was founded by Augustine Y. Cheung in 1982 under the name Cheung Laboratories, Inc. It changed its name to Celsion Corporation in 1998. Celsion Corporation is based in Columbia, Maryland.
CANDELA CORPORATION (CLZR)
Candela Corporation engages in the research, development, manufacture, marketing, sale, and servicing of lasers and light-based products used to perform aesthetic and cosmetic procedures worldwide. Its product line includes GentleLASE family of lasers for the treatment of unwanted hair and for the treatment of vascular lesions, pigmented lesions, and wrinkles; Vbeam for the treatment of vascular lesions, wrinkles, psoriasis, and other conditions; ALEXLAZR for the treatment of pigmented lesions and tattoos; Smoothbeam diode laser for nonablative dermal remodeling of wrinkles, and the treatment of acne and acne scars; C-beam pulsed dye laser for treatment of psoriasis and surgical scars; and Ellipse Intense Pulsed Light system for the improvement of sun-damaged skin by photo rejuvenation through removal of both vascular and dyspigmentation. The company sells its products directly and through a network of distributors to plastic and cosmetic surgeons; dermatologists; general practitioners; and certain specialists, including obstetricians, gynecologists, and general and vascular surgeons. Candela Corporation was founded in 1969 and is headquartered in Wayland, Massachusetts.
CHINA MEDICAL TECHNOLOGIES INC (CMED)
China Medical Technologies, Inc. develops, manufactures, and markets medical devices for the treatment of solid cancers and benign tumors in the People's Republic of China. It offers In-vitro diagnostics systems, which include enhanced chemiluminescence immunoassay (ECLIA) system and fluorescent in situ hybridization (FISH) imaging analysis system and probes. The company's ECLIA system consists of ECLIA analyzer for detecting minute levels of light triggered by combining reagents with body fluid samples to produce diagnostic results; reagent kits, which are formulated to create various reactions with blood or other body fluid samples; and a data analysis system to analyze and organize the information produced form diagnostic results. It offers 62 types of reagent kits for use with the ECLIA analyzer for detecting and monitoring various types of diseases and disorders, including thyroid disorders, diabetes, hepatitis, and disorders related to reproduction and growth, SARS, Down syndrome, liver fibrosis, and various types of tumors. China Medical Technologies also offers FISH imaging analysis system and probes, which uses FISH technology for prenatal and postnatal diagnosis, and early detection and prognosis of various cancers. In addition, the company provides HIFU therapy system to treat liver, breast, and kidney tumors; solid tumors in the pelvic cavity or on bone; and tumors in the four limbs or superficial tissues. It sells its products through direct sales force and distributors. China Medical Technologies was founded in 1999 and is based in Beijing, the People's Republic of China.
CONMED CORPORATION (CNMD)
CONMED Corporation, a medical technology company, offers instruments, implants, and video equipment for arthroscopic sports medicine, as well as powered surgical instruments, such as drills and saws for orthopedic, otolaryngologic, neurosurgery, and other surgical specialties. The company develops, manufactures, and supplies radio frequency electrosurgery systems that are used to cut and cauterize tissue in various types of surgical procedures worldwide; endosurgery products, such as trocars, clip appliers, scissors, and surgical staplers; and electrocardiogram electrodes for heart monitoring and other patient care products. It also offers integrated operating room systems and equipment. The company's CONMED Endoscopic technologies offer a portfolio of disposable products used by gastroenterologists to diagnose and treat diseases of the digestive tract. Its products are used in various clinical settings, such as operating rooms, surgery centers, physicians' offices, and hospitals. The company distributes its products through medical specialty distributors and surgeons to hospitals and other healthcare institutions. CONMED was incorporated in 1970. The company was founded by Eugene R. Corasanti. CONMED Corporation is headquartered in Utica, New York.
Continucare Corporation provides primary care physician services on an outpatient basis in Florida. It provides medical services to patients through employee physicians, nurse practitioners, and physician's assistants. The company also provides practice management services to independent physician affiliates (IPAs), including assistance with medical utilization management, pharmacy management, and specialist network development. As of September 30, 2005, the company provided practice management services to 27 IPAs; and operated a network of 15 medical centers in Miami-Dade, Broward, and Hillsborough Counties, Florida. The company also provided services to or for approximately 13,400 patients on a full risk basis and approximately 14,600 patients on a limited or nonrisk basis, as of the above date. Continucare has managed care agreements with Humana Medical Plans, Inc.; Vista Healthplan of South Florida, Inc.; and Wellcare, Inc. The company was founded in 1996 and is headquartered in Miami, Florida.
COOPER COMPANIES INC (COO)
The Cooper Companies, Inc. engages in the development, manufacture, and marketing of healthcare products worldwide. It operates in two segments, CooperVision and CooperSurgical. The CooperVision segment develops, manufactures, and markets a range of contact lenses for the vision care market. It specializes in toric lenses that correct astigmatism; cosmetic lenses, which change the appearance of the color of the eye; and other lenses. The CooperSurgical segment engages in the development, manufacture, and marketing of medical devices, diagnostic products, and surgical instruments and accessories, which are used primarily by gynecologists and obstetricians. The company markets its products through field sales representatives and distributors in the United States, Canada, the United Kingdom, Brazil, Portugal, Italy, Spain, France, Holland, Sweden, Norway, Australia, and South Africa. The company was organized in 1980 and is based in Pleasanton, California. The Cooper Companies, Inc. acquired Ocular Sciences, Inc., a contact lens manufacturer, in January 2005.
Conceptus, Inc. engages in the development, manufacture, and marketing of medical products for women's health in the United States. The company offers Essure, a permanent birth control device for women that provides a nonincisional alternative to tubal ligation. It markets its product primarily in Australia, Canada, Europe, Indonesia, Singapore, and the United States. Conceptus was founded in 1992 and is headquartered in San Carlos, California.
COGDELL SPENCER INC (CSA)
Cogdell Spencer, Inc. owns specialty office properties for the medical profession in the southeastern United States. It primarily engages in the ownership, development, redevelopment, acquisition, and management of medical office buildings and other healthcare-related facilities. Cogdell Spencer owns and/or manages 73 medical office buildings and healthcare-related facilities, which include 45 wholly owned properties; 8 joint venture properties; 16 properties owned by third parties; and 4 properties held for sale. The company intends to qualify as a real estate investment trust for federal income tax purposes. Cogdell Spencer was founded in 1972 and is headquartered in Charlotte, North Carolina.
CAPITAL SENIOR LIVING CORPORATION (CSU)
Capital Senior Living Corporation (CSLC) engages in the ownership, operation, development, and management of senior living communities throughout the United States. The company provides various senior living services to the elderly, including independent living, assisted living, skilled nursing, and home care services. Its independent living services include daily meals, transportation, social and recreational activities, laundry, housekeeping, health care monitoring, and 24-hour staffing. CSLC's assisted living care and services include personal care services, support services, and supplemental services. It provides traditional long-term care services through registered nurses, licensed practical nurses, and certified nursing assistants in skilled nursing facilities. The company also offers a range of restorative nursing and rehabilitation services in its communities, including physical, occupational, speech, and medical social services. In addition, it also provides private pay and home care services to its clients, as well as offers customized physician, dentistry, podiatry, and other health-related services. As of December 31, 2004, the company operated 54 senior living communities in 20 states, as well as a home care agency. The company was incorporated in 1996 and is headquartered in Dallas, Texas.
CHAD THERAPEUTICS INC (CTU)
CHAD Therapeutics, Inc. engages in the development, production, and marketing of respiratory care devices for home health care and hospital treatment of patients suffering from pulmonary diseases. The company's products include OXYMIZER and OXYMIZER Pendant oxygen-conserving devices; OXYMATIC electronic oxygen conservers for use with portable oxygen systems; CYPRESS OXYPneumatic conservers; SAGE oxygen therapeutic device for oxygen desaturation problem; OXYCOIL coiled oxygen tubing, which replaces the standard supply tubing for the OXYMIZER devices, the OXYMATIC conserver, or conventional nasal cannulas; and TOTAL O2 delivery system, which provides stationary oxygen for patients at home and portable oxygen. In addition, the company offers various ancillary products that support the principal oxygen conserving products. These products include oxygen cylinders of various sizes and compositions, regulators, cannulas and connecting tubing, and assorted carrying pouches. The company sells its products through direct sales staff, distributors, and independent manufacture's sales representatives. It markets its products primarily in the North America, Japan, and Europe. CHAD Therapeutics was founded by Charles R. Adams in 1982. The company is based in Chatsworth, California.
COMMUNITY HEALTH SYSTEMS INC (CYH)
Community Health Systems, Inc. engages in the ownership, lease, and operation of acute care hospitals in the United States. Its hospitals offer a range of inpatient and outpatient medical and surgical services, including orthopedics, cardiology, occupational medicine, diagnostic services, emergency services, rehabilitation treatment, home health, and skilled nursing. As of December 31, 2004, it owned, leased, or operated 71 hospitals in 22 states, with an aggregate of 7,888 licensed beds. The company was organized in 1985 and is based in Brentwood, Tennessee.
DATATRAK INTERNATIONAL INC (DATA)
DATATRAK International, Inc. serves as an application service provider in the electronic data capture industry. The company principally provides software and other related services, which enable its customers to collect and transmit clinical trial data electronically. It offers DATATRAK EDC software suit, an e-process solution, to provide electronic data capture and other services to clinical trial sponsors and contract research organizations. The DATATRAK EDC suit consists of DATATRAK Entry, DATATRAK Review, DATATRAK Design, and DATATRAK Report/Export modules for various applications. Its customers include the clinical, pharmaceutical, biotechnology, contract research organizations, and medical device research industries. DATATRAK International markets its software and services primarily in the United States, Canada, and Germany. It has an alliance agreement with SAS Institute, Inc. The company was founded by Jeffrey A. Green in 1991. DATATRAK International is headquartered in Mayfield Heights, Ohio.
DIALYSIS CORPORATION OF AMERICA (DCAI)
Dialysis Corporation of America, through its subsidiaries, engages in the development and operation of outpatient kidney dialysis centers. The company provides dialysis and ancillary services to patients suffering from chronic kidney failure, also known as end-stage renal disease (ESRD) through these centers. It also provides acute inpatient dialysis treatments in hospitals, homecare services, and dialysis center management services. As of September 30, 2005, the company owned 24 operating dialysis centers located in Georgia, Maryland, New Jersey, Ohio, Pennsylvania, South Carolina, and Virginia; and managed 2 other dialysis facilities located in Ohio and Georgia. Its ancillary services to ESRD patients include the administration of certain prescription drugs. Dialysis Corporation was organized in 1976 and is based in Linthicum, Maryland.
QUEST DIAGNOSTICS INCORPORATED (DGX)
Quest Diagnostics Incorporated provides diagnostic testing, information, and services for the healthcare industry in the United States. It offers esoteric testing, such as gene-based testing and testing for drugs of abuse; and anatomic pathology services and testing to support clinical trials of new pharmaceuticals worldwide. Quest Diagnostics manufactures and markets diagnostic test kits and systems primarily for esoteric testing, which are sold to hospitals, clinical laboratories, and dialysis centers domestically and internationally, through its subsidiary, Nichols Institute Diagnostics. The company offers a range of clinical laboratory testing services to patients, physicians, hospitals, healthcare insurers, employers, governmental institutions, and other commercial clinical laboratories. It operates a network of approximately 1,900 patient service centers and laboratories located in approximately 30 metropolitan areas in the United States. The company markets its products to customers through its direct sales force, healthcare insurers sales force, customer service representatives, and couriers. Quest Diagnostics is headquartered in Lyndhurst, New Jersey.
DIGITAL ANGEL CORPORATION (DOC)
Digital Angel Corporation engages in the development and deployment of sensor and communications technologies that enable the identification, location tracking, and condition monitoring people, animals, and objects. It operates in two segments, Animal Applications and, GPS and Radio Communications. The Animal Applications segment develops, manufactures, and markets a line of electronic and visual identification devices for the companion animal, livestock, laboratory animal, fish, and wildlife markets worldwide. This segment principally employs electronic ear tags and implantable microchips that use radio frequency transmission. The GPS and Radio Communications segment designs, manufactures, and supports global positioning systems enabled equipment for location tracking and message monitoring of vehicles and aircraft in remote locations, as well as for telemetry, mobile data, and radio communications applications. The company is headquartered in South Saint Paul, Minnesota. Digital Angel Corporation is a subsidiary of Applied Digital Solutions, Inc.
Datascope Corp. engages in the development, manufacture, and marketing of products for clinical health care markets in interventional cardiology and radiology, cardiovascular and vascular surgery, anesthesiology, emergency medicine, and critical care. The company operates in two segments, Cardiac Assist/Monitoring Products and Interventional Products/Vascular Grafts. The Cardiac Assist/Monitoring Products segment offers electronic intra-aortic balloon pumps and catheters that are used in the treatment of cardiovascular disease and electronic physiological monitors that provide for patient safety and management of patient care. The Interventional Products/Vascular Grafts segment offers vascular sealing devices, which are used to seal arterial puncture wounds to stop bleeding after cardiovascular catheterization procedures; interventional radiology products used in dialysis access; and a line of knitted and woven polyester vascular grafts and patches for reconstructive vascular and cardiovascular surgery. The company markets its products through direct sales representatives and independent distributors primarily in the United States, Europe, and Japan. Datascope was organized in 1964 and is headquartered in Montvale, New Jersey.
DaVita, Inc. provides dialysis services in the United States for patients suffering from chronic kidney failure, also known as end stage renal disease (ESRD). The company operates kidney dialysis centers and provides related medical services primarily in dialysis centers and in contracted hospitals across the United States. Its services include outpatient dialysis services; hospital inpatient dialysis services; and ancillary services, such as ESRD laboratory services and disease management services. The company's subsidiary, DaVita Clinical Research, conducts renal and renal-related research trials of new drugs and devices. As of December 31, 2004, DaVita operated or provided administrative services to 660 outpatient facilities serving approximately 54,000 patients in 37 states and the District of Columbia. In addition, it also provided acute inpatient dialysis services in approximately 370 hospitals. DaVita is headquartered in El Segundo, California.
Daxor Corporation operates as a medical device manufacturing and biotechnology company in the United States. It is developing BVA-100, which measures human blood volume. This instrument is used in conjunction with a single use radiopharmaceutical diagnostic injection kit known as Volumex. BVA-100 has an accuracy of approximately 98% while also providing the predicted normal blood volume for that specific individual based on the height, weight, and sex of the patient. Daxor's patented Volumex utilizes Albumin I-131, a classic tracer used for blood volume measurement. The company, through its wholly owned subsidiary, Scientific Medical Systems, operates a frozen blood bank in New York that allows people to store their own blood utilizing cryobiology technology for approximately 10 years. In addition, Idant, a division of the Scientific Medical subsidiary, provides sperm banking services. The company also provides special screening for rare hereditary recessive genetic traits. Daxor was founded in 1970 and is based in New York City.
DYNACQ HEALTHCARE INC (DYII)
Dynacq Healthcare, Inc., through its subsidiaries, engages in the development and management of general acute care hospitals that principally provide specialized general surgeries, such as bariatric, orthopedic, and neuro-spine surgeries primarily in the United States. The company also provides fertility, sleep laboratory, and pain management services, as well as minor emergency treatment services; and ear, nose, and throat services. Its hospitals include operating rooms, pre and postoperative space, intensive care units, nursing units, and diagnostic facilities, as well as medical office buildings that lease space to physicians and other healthcare providers. As of August 31, 2005, it owned four hospital facilities in the United States, as well as a 70% equity interest in Shanghai DeAn Hospital, a joint venture formed for the purpose of constructing a hospital in Shanghai, China. The company was incorporated in 1983. It was formerly known as Dynacq International, Inc. and changed its name to Dynacq Healthcare, Inc. in 2003. Dynacq Healthcare is based in Houston, Texas.
DYNATRONICS CORPORATION (DYNT)
Dynatronics Corporation engages in the design, manufacture, marketing, and distribution of physical medicine products and aesthetic products. It offers a line of medical equipment, including therapy devices, medical supplies and soft goods, treatment tables, and rehabilitation equipment. In addition, the company manufactures and distributes a line of aesthetic equipment that consists of aesthetic massage and microdermabrasion devices, as well as provides skin care products. Dynatronics' products are primarily used by physical therapists, chiropractors, sports medicine practitioners, podiatrists, plastic surgeons, dermatologists, aestheticians, and other aesthetic services providers. It distributes its products primarily through a network of independent dealers, direct relationships with certain national accounts, and full-line catalog, as well as through manufacturer representatives and direct sales force in the United States and internationally. Dynatronics was founded in 1983 and is headquartered in Salt Lake City, Utah.
HearUSA, Inc. operates hearing care centers in the United States and Canada. The company operates in three segments: Company-Owned Centers (COC), Network of Independent Providers (NIP), and E-Commerce Business (ECB). The COC segment offers various products and services, including diagnostic audiological testing for hearing aids and assistive listening. As of December 31, 2004, it owned 154 centers in 11 states and in the Province of Ontario, Canada. The NIP segment operates a network of approximately 1,400 credentialed audiology providers that support hearing benefit programs with employer groups, health insurers, and benefit sponsors. The ECB segment offers on-line information about hearing loss, hearing aids, assistive listening devices, and the services offered by hearing health care professionals. It also offers on-line purchases of hearing related products, such as batteries, hearing aid accessories, and assistive listening devices. HearUSA was organized as HEARx, Ltd. in 1986 and changed its name to HearUSA, Inc. in 2002. The company is based in West Palm Beach, Florida.
ELBIT MEDICAL IMAGING LTD (EMITF)
Elbit Medical Imaging, Ltd., through its subsidiaries, engages in the ownership, construction, operation, and management of hotels, and commercial and entertainment malls in central and eastern Europe. The company also owns and operates an entertainment and commercial center in Israel, as well as involves in the research and development, production, and marketing of image guided focused ultrasound treatment equipment. As of December 31, 2004, it had an aggregate of four operating commercial and entertainment malls in Poland, as well as an aggregate of eight malls in various stages of development and planning in Poland, the Czech Republic, Latvia, and Greece. The company was incorporated in 1996 and is based in Tel-Aviv, Israel. Elbit Medical Imaging, Ltd. is a subsidiary of Europe Israel, (M.M.S.), Ltd.
EntreMed, Inc., a clinical-stage biopharmaceutical company, engages in the development of therapeutics primarily for the treatment of cancer. It develops multimechanism oncology and anti-inflammatory drugs that target disease cells directly and the blood vessels that nourish them. The company's lead drug candidate Panzem (2-methoxyestradiol or 2ME2) is in clinical trials for cancer, as well as in preclinical development for nononcology indications. Panzem is in Phase I and Phase II clinical trials. The company also develops various molecules, including analogs of 2ME2, modulators of fibroblast growth factor-2 activity, tissue factor pathway inhibitor peptides, and proteinase activated receptor-2 antagonists to inhibit tumor growth and angiogenesis activities. The company has a strategic alliance with Allergan to develop and commercialize small molecule angiogenic inhibitors for the treatment and prevention of diseases and conditions of the eye; research collaboration with Affymax, Inc. to identify lead tissue factor pathway inhibitor drug candidates for the treatment of cancer; and a cooperative research and development agreement with the National Cancer Institute to evaluate the role of HIF-1alpha inhibition in the treatment of cancer. EntreMed was incorporated in 1991 and is based in Rockville, Maryland.
Enzo Biochem, Inc., together with its subsidiaries, engages in the research, development, manufacture, and marketing of diagnostic and research products based on genetic engineering, biotechnology, and molecular biology. These products are designed for the diagnosis of and/or screening for infectious diseases, cancers, genetic defects, and other medically pertinent diagnostic information. The company's major product categories include preformatted in situ kits, preformatted microplate kits, membrane kits, labeled probes, and labeling and signaling reagents. It is also conducting research and development activities in the development of therapeutic products based on the company's technology platform of genetic modulation and immune modulation. Enzo Biochem is evaluating its proprietary gene medicine for HIV-1 infection, as well as its proprietary immune regulation medicines for hepatitis B and hepatitis C infection, and for Crohn's Disease. In addition, it operates a regional clinical reference laboratory that provides diagnostic services to the greater New York and New Jersey medical community. This laboratory offers a menu of routine and esoteric clinical laboratory tests or procedures. These tests are frequently used in general patient care by physicians to establish or support a diagnosis, monitor treatment or medication, or search for an otherwise undiagnosed condition. Enzo Biochem markets its products and services through direct sales, manufacturers, and distributors. The company was co-founded by Elazar Rabbani, Shahram K. Rabbani, and Barry W. Weiner in 1976. Enzo Biochem is headquartered in Farmingdale, New York.
EP MedSystems, Inc. engages in the development, manufacture, and marketing of a line of products for the cardiac electrophysiology market. The company's products are used to diagnose, monitor, visualize, and treat irregular heartbeats known as arrhythmias. Its products include EP-WorkMate, a computerized electrophysiology workstation that monitors, displays, and stores cardiac electrical activity and arrhythmia data; EP-3 stimulator; the RealTime Position Management navigation technology; EP-4 computerized cardiac stimulator; diagnostic electrophysiology catheters; and ALERT System, which uses an electrode catheter to deliver bi-phasic electrical impulses directly to the inside of the heart to convert atrial fibrillation to a normal heart rhythm in the treatment of atrial fibrillation. The company also offers ViewMate intracardiac ultrasound catheter system that provides visualization to the inside chambers of the heart, as well as related disposable supplies. EP MedSystems sells its products primarily to medical institutions and physicians in the United States and France. It has strategic alliances with Boston Scientific Corporation and Philips Medical. The company was founded by David A. Jenkins in 1993 and is headquartered in West Berlin, New Jersey.
EMERITUS CORPORATION (ESC)
Emeritus Corporation, an integrated assisted living company, operates residential style communities in the United States. These communities provide basic services, assisted living services, and special care program for senior citizens who need help with the activities of daily living. Its basic services include three nutritious meals per day; social and recreational activities; weekly housekeeping and linen service; building maintenance; individual apartment maintenance and grounds keeping; 24-hour emergency response and security; licensed nurses available to monitor and coordinate care needs, organize wellness activities, and transportation to appointments; and excursions for independent, assisted living, and those with Alzheimer's and related dementia. The company's assisted living services consist of medication management and supervision; reminders for dining and recreational activities; assistance with bathing, dressing, and grooming; incontinence care and assistance; psycho-social support; dining assistance; and miscellaneous services, such as diabetic management, prescription medication reviews, transfers, and simple treatments for assisted living residents. Emeritus Corporation's special care programs include personalized environment, activities planned to support interactions, and specialized dining and hydration programs, as well as partnerships with families and others through support groups, one-on-one meetings, and educational forums for residents with Alzheimer's and related dementias. The company also provides management services to independent and related-party owners of assisted living communities. As of March 31, 2005, Emeritus had interests in 182 communities representing capacity for approximately 18,400 residents in 34 states. The company was founded by Daniel R. Baty, Raymond R. Brandstrom, and Frank A. Ruffo Jr. in 1993. Emeritus is headquartered in Seattle, Washington.
ESCALON MEDICAL CORP (ESMC)
Escalon Medical Corp. engages in the development, manufacture, marketing, and distribution of medical devices and pharmaceuticals in the areas of ophthalmology, diabetes, hematology, and vascular access. It provides instruments for blood cell counting and blood analysis; and supplies the reagent and other consumable materials needed to operate the instruments. The company also sells diabetic testing products, including DS5 that measures long-term glucose control in diabetic patients; and Hb-Gold, which provides for in vitro measurement of certain genetic diseases of the blood. In addition, it offers equipment for use in the field of human and veterinary hematology. The company also manufactures and markets ultrasound systems for diagnostic or biometric applications in ophthalmology, including A-Scans, B-Scans, High frequency B-Scans, and pachymeters. Further, it develops, manufactures, and markets vascular access products that include Doppler-guided vascular access assemblies used to locate desired vessels for access. Escalon Medical also provides ophthalmic surgical products to vitreoretinal ophthalmic surgeons; distributes intraocular gas products, C3F8 and SF6, which are used by vitreoretinal surgeons as a temporary tamponade in detached retina surgery; light sources, including various fiber optic probes and illuminated tissue manipulators; and CFA camera system. The company also offers viscous fluid transfer systems and related disposable syringe products, which aid in the process of injecting and extracting silicone oil. The company has license and distribution rights for Povidone-Iodine 2.5% solution, an anti-microbial to prevent ophthalmia neonatorum in newborns. It sells its product to surgeons, laboratories, medical institutions, educational institutions, and ophthalmologists. The company was incorporated in 1987 and is based in Wayne, Pennsylvania.
EXPRESS SCRIPTS INC (ESRX)
Express Scripts, Inc. operates as a pharmacy benefit management (PBM) company in North America, providing health care management and administration services. The company's integrated PBM services include network claims processing, mail pharmacy services, specialty prescription fulfillment, benefit design consultation, drug utilization review, formulary management, disease management, and drug data analysis services. Express Scripts also provides nonPBM services, including pharmaceuticals distribution services through its Express Scripts Specialty Distribution Services subsidiary; and drug sample fulfillment and sample accountability services through its subsidiary Phoenix Marketing Group, Inc. The company's clients include health maintenance organizations, health insurers, third-party administrators, employers, union-sponsored benefit plans, and government health programs. Express Scripts was established in 1986 and is headquartered in St. Louis, Missouri.
EDWARDS LIFESCIENCES CORPORATION (EW)
Edwards Lifesciences Corporation provides products and technologies designed to treat advanced cardiovascular disease. It provides products and technologies to address heart valve disease, peripheral vascular disease, and critical care technologies. The company's products and technologies are categorized into five areas: heart valve therapy, critical care, cardiac surgery systems, vascular, and other distributed products. Its heart valve therapy portfolio comprises tissue heart valves and heart valve repair products that are used to replace or repair a patient's diseased or defective heart valve. In the critical care area, the company provides hemodynamic monitoring systems used to measure a patient's heart function, as well as disposable pressure transducers and central venous access products for fluid and drug delivery. The company's cardiac surgery systems portfolio consists of a diverse line of products, including oxygenators, blood containers, filters, and other disposable products used during cardiopulmonary bypass procedures, cannulae, and transmyocardial revascularization technology. Edwards Lifesciences' vascular portfolio includes a line of balloon catheter-based products, surgical clips and inserts, angioscopy equipment, artificial implantable grafts, and stents used in the treatment of peripheral vascular disease. In addition, the company's other distributed products include intra-aortic balloon pumps, pacemakers, and other products. It distributes its products through direct sales force and independent distributors primarily in the United States, Canada, and Europe. Edwards Lifesciences was incorporated in 1999 and is headquartered in Irvine, California.
Exactech, Inc. engages in the development, manufacture, marketing, distribution, and sale of orthopaedic implant devices, related surgical instrumentation, and biologic materials to hospitals and physicians in the United States and internationally. The company offers Optetrak knee system, a modular system designed to improve the movement of the knee cap, which is called patellar tracking and reduces the force between surfaces in a joint, and provides a functional range of motion. It also offers AcuMatch integrated hip system, which is designed to address the requirements for total hip replacement, including primary and revision needs. Exactech also distributes bone paste materials for use in nonspinal musculoskeletal orthopaedic procedures. Its allograft materials are distributed as Opteform and Optefil, and are used for repairing bone and filling bone defects. In addition, the company offers AcuDriver automated osteotome system, an air-driven impact hand piece that assists surgeons during joint implant revision procedures by aiding in removal of failed prostheses and bone cement; and distributes Link surgical instrumentation that can be used in various orthopaedic procedures, including shoulder, knee, spine, foot, ankle, and hip arthroplasty; and offers Cemex bone cement system featuring a self-contained delivery system. Exactech markets its orthopaedic implant products in the United States through independent sales agencies and domestic distributors. The company was co-founded by William Petty, Betty Petty, and Gary J. Miller in 1985. Exactech is headquartered in Gainesville, Florida.
ADVANCED MEDICAL OPTICS INC (EYE)
Advanced Medical Optics, Inc. (AMO) engages in the development, manufacture, and marketing of surgical devices for the eyes worldwide. It has two product lines, ophthalmic surgical and eye care. The company's ophthalmic surgical product line provides medical devices for use in the cataract and refractive surgery markets. Cataract surgery market focuses on four products, including foldable intraocular lenses (IOLs), implantation systems, phacoemulsification systems, and viscoelastics. Refractive surgery market, in addition to IOLs and viscoelastics, markets microkeratomes for use in the LASIK procedure. AMO's eye care product line provides a range of contact lens care products for use with various contact lenses. These products include single-bottle, multipurpose cleaning and disinfecting solutions, hydrogen peroxide-based disinfecting solutions, daily cleaners, enzymatic cleaners, and contact lens rewetting drops. The company's customers include surgeons, hospitals, ambulatory surgical centers, optometrists, opticians, ophthalmologists, and retailers, such as mass merchandisers and drug store chains. It has direct operations in approximately 20 countries; and markets and sells its products in approximately 60 countries, including Europe. AMO has operations in North and South America, Europe, Africa, Middle East, Japan, and Asia Pacific. Advanced Medical Optics was incorporated in 2001 and is based in Santa Ana, California.
FRESENIUS MEDICAL CARE CORPORATION (FMS)
No description available.
FONAR Corporation engages in the research, development, production, and marketing of medical scanning equipment, which utilizes magnetic resonance imaging technology (MRI) for the detection and diagnosis of human diseases. Its principal products include Stand-Up/Upright MRI, which allows patients to be scanned in a fully weight bearing condition, such as standing, sitting, or bending in any position that causes symptoms; and FONAR 360, a room-size recumbent scanner that optimizes openness while facilitating physician access to the patient. The company also provides management services to physician's practices and other medical providers, including diagnostic imaging centers and ancillary services. These services include development; administration; leasing of office space; facilities and medical equipment; provision of supplies; staffing and supervision of nonmedical personnel; legal services; accounting, billing, and collection; and the development and implementation of practice growth and marketing strategies. The company offers its products and services primarily to private scanning centers and hospitals in the United States, Europe, and the Middle East. FONAR Corporation was formed in 1978 and is headquartered in Melville, New York.
Langer, Inc. engages in the design, manufacture, and distribution of medical products for the orthopedic, orthotic, and prosthetic markets. The company operates in two segments, Orthopedic and Skincare. The Orthopedic segment offers a line of approximately 500 orthopedic products, including custom foot and ankle orthotic devices, prefabricated foot products, rehabilitation products, and gel-based orthopedic and prosthetics products for patients to correct, protect, and heal. The Skincare segment provides a line of approximately 50 skincare products for the medical, therapeutic, and retail markets. Its products include scar management products, and gel-based therapeutic gloves and socks for skin appearance, as well as for transmission of moisture agents, vitamins, and nutrients to the skin. Langer sells its products primarily to independent medical distributors and directly to healthcare professionals in the United States and Canada, as well as in approximately 30 other countries. It markets its products to podiatrists, orthopedists, orthopedic surgeons, dermatologists, cosmetic and plastic surgeons, occupational and physical rehabilitation professionals, prosthetists, orthotists, and various healthcare professionals. The company was formerly known as Langer Biomechanics Group, Inc. and changed its name to Langer, Inc. in 2001. Langer is headquartered in Deer Park, New York.
GREENBRIAR CORPORATION (GBR)
CabelTel International Corporation provides cable television services in Bulgaria. Its telecommunications activities include providing subscription cable television, fixed voice telephony services, and data services in Bulgaria and surrounding countries. The company offers cable television services to approximately 130,000 households. It also engages in the ownership and operation of real estate, comprising a retirement community in King City, Oregon, with a capacity for 114 residents, as well as an outlet mall in Gainesville, Texas with approximately 315,000 square feet of retail space available for lease. In addition, CabelTel International owns oil and gas leases in Gregg and Rusk Counties, Texas. As of June 30, 2005, it operated 48 producing wells. The company was founded in 1999 and is based in Dallas, Texas.
GENEREX BIOTECHNOLOGY CORPORATION (GNBT)
Generex Biotechnology Corporation engages in the research and development of drug delivery systems and technology. Its products include morphine, fentanyl, heparin, and flu vaccine, which are used medically for pain relief and as a sedative. The company also offers Oralin product, which is a proprietary insulin formulation used for diabetes management. Its Oralin product is delivered through RapidMist device, which is used to administer large molecule drugs, including proteins, peptides, monoclonal antibodies, hormones, and vaccines. The company, through its subsidiary, Antigen Express, Inc., conducts research and development of technologies and immunomedicines for the treatment of malignant, infectious, autoimmune, and allergic diseases. Generex Biotechnology was founded in 1983 and is based in Ontario, Canada.
HAEMONETICS CORPORATION (HAE)
Haemonetics Corporation engages in the design, manufacture, and marketing of automated systems and single-use disposables for the collection, processing, and surgical salvage of donor and patient blood. The company's systems enable users to collect and process the blood component they target, such as plasma, platelets, or red blood cells. Its products include PCS brand systems, which automate the collection of plasma from donors; MCS, which automate the collection of platelets; ACP that automate the process used to freeze, thaw, and wash red blood cells. The company's surgical blood salvage systems are used during and after surgery to collect a patient's own blood for reinfusion. These systems include Cell Saver brand systems for higher blood loss surgeries and trauma; OrthoPAT brand systems for lower, slower blood loss procedures; and cardioPAT brand system for blood loss during and after beating heart surgeries or for blood loss after various coronary artery bypass graft surgeries. The company offers its products primarily through direct sales force, independent distributors, and agents principally in the United Sates, Europe, and Japan and other parts of Asia. Haemonetics was founded in 1971 and is based in Braintree, Massachusetts.
Manor Care, Inc. provides various health care services in the United States. Its services include nursing care, assisted living, subacute medical and rehabilitation care, rehabilitation therapy, hospice care, home health care, and management services for subacute care and rehabilitation therapy. The company through its nursing centers provides physical, speech, respiratory, and occupational therapy for patients recovering from strokes, heart attacks, orthopedic conditions, or other illnesses, injuries, or disabilities. In addition, its centers provide nutrition, social service, and housekeeping and laundry services. It also provides medical and rehabilitation programs for patients recovering from surgery, injury, or cardiovascular, respiratory, infectious, endocrine, or neurological illnesses. Manor Care provides services and facilities for Alzheimer's patients. Its hospice services focus on the physical, spiritual, and psychosocial needs of individuals facing a life-limiting illness. The home health care assists those who wish to stay at home or in assisted living residences but still require some degree of medical care or assistance with daily activities. It also provides services, such as wound care and dressing changes; infusion therapy; cardiac rehabilitation; and physical, occupational, and speech therapies. As of December 31, 2004, the company operated 279 nursing facilities and 65 assisted living facilities in 31 states. Manor Care provides rehabilitation therapy in its long-term care centers, other centers, hospitals schools, work sites, and in its 89 outpatient therapy clinics serving the midwestern and mid-Atlantic states, Texas, and Florida. In addition, the company is a majority owner in a medical transcription business, which converts medical dictation into electronically formatted patient records. Manor Care is headquartered in Toledo, Ohio.
HANGER ORTHOPEDIC GROUP INC (HGR)
Hanger Orthopedic Group, Inc. engages in the ownership and operation of orthotic and prosthetic patient-care centers in the United States. It offers various patient-care services, including fabrication, fitting, and maintenance of orthotic and prosthetic devices. The company's orthotics operations offer standard and custom-made braces, and other devices, such as spinal, knee, and sports-medicine braces that provide external support to patients suffering from musculoskeletal disorders, such as ailments of the back, extremities or joints, and injuries from sports or other activities. Its prosthetics operations provide custom-made artificial limbs for patients who are without limbs as a result of traumatic injuries, vascular diseases, diabetes, cancer, or congenital disorders. Hanger Orthopedic Group also distributes branded and private label orthotic and prosthetic devices and components in the United States, which are manufactured by third parties. As of December 31, 2004, the company operated approximately 619 patient care centers in 44 states and the District of Columbia. Hanger Orthopedic Group was founded in 1861 and is headquartered in Bethesda, Maryland.
Hooper Holmes, Inc., together with its subsidiaries, provides outsourced risk assessment services to the life and health insurance industry, and medical evaluation and claims management services to the automobile insurance industry and the workers' compensation industry in the United States and United Kingdom. The company provides paramedical and medical examinations, including blood and urine specimen collection, primarily in connection with insurance carriers' processing and evaluation of the risks associated with underwriting insurance policies; tele-underwriting, telephone personal health interviews, and medical records retrieval; and laboratory testing services. In addition, it provides medical claims services, which primarily includes the arrangement of independent medical exams for the purpose of determining the nature, source, and extent of injury to insurance adjusters for use in processing accident claims, primarily on behalf of property and casualty insurance carriers. In addition, Hooper Holmes provides other services, including the preparation of general practitioner reports for the legal, corporate, and insurance industries; underwriting of life insurance policies on an outsourced basis, without the mortality risks attendant to such underwriting activity; and pre and post employment physical examination screening services for public transportation and corporate agencies. Hooper Holmes operates through approximately 160 branch offices and 76 contractor affiliate offices located in the United States and the United Kingdom. The company is based in Basking Ridge, New Jersey.
HEALTH MANAGEMENT ASSOCIATES INC (HMA)
Health Management Associates, Inc. engages in the ownership and operation of general acute care hospitals and psychiatric hospitals in nonurban communities primarily in the southeastern and southwestern United States. Its services include general surgery, internal medicine, obstetrics, emergency room care, radiology, oncology, diagnostic care, coronary care, pediatric services, behavioral health services, and psychiatric care. The company also provides outpatient services, such as one-day surgery, laboratory, x-ray, respiratory therapy, cardiology, and physical therapy. In addition, it offers specialty services in cardiology, such as open-heart surgery; neuro-surgery; oncology; radiation therapy; CT scanning; MRI imaging; lithotripsy; and full-service obstetrics. As of September 30, 2005, the company operated 57 hospitals, consisting of 55 acute care hospitals with approximately 8,128 beds; and 2 psychiatric hospitals with approximately 182 beds. Health Management Associates was formed in 1977 and is headquartered in Naples, Florida.
Health Net, Inc. operates as a managed health care company in the United States. The company's health maintenance organizations, point of service (POS), insured preferred provider organizations (PPO), and government contracts subsidiaries provide health benefits through various programs, including group, individual, Medicare, Medicaid, and TRICARE. Its health plans offer its members a range of health care services, such as ambulatory and outpatient physician care, hospital care, pharmacy services, behavioral health, and ancillary diagnostic and therapeutic services. The company also offers managed health care products related to behavioral health and prescription drugs. In addition, Health Net owns interests in health and life insurance companies that are licensed to sell exclusive provider organization, PPO, POS, and indemnity products, as well as auxiliary nonhealth products, such as life and accidental death and dismemberment, dental, vision, behavioral health, and disability insurance. The company is headquartered in Woodland Hills, California.
Hologic, Inc. engages in the development, manufacture, and supply of diagnostic and medical imaging systems for serving the healthcare needs of women. It focuses on mammography and bone densitometry. The company's mammography products include the Selenia full field digital mammography system and a series of screen-film mammography systems, breast biopsy image guidance systems, and other systems. Its osteoporosis assessment products consist of a family of QDR X-ray bone densitometers; and the Sahara Clinical Bone Sonometer, an ultrasound device that assesses the bone density of the heel. Hologic also offers Fluoroscan mini C-arm imaging systems for orthopedic surgeons to perform minimally invasive surgical procedures on a patient's extremities, such as the hand, wrist, knee, foot, and ankle. In addition, it provides digital detector products for original equipment manufacturers to incorporate into their own equipment, as well as minimally invasive stereotactic breast biopsy guidance systems, such as MultiCare Platinum prone breast biopsy table and the StereoLoc II upright attachment that provide an alternative to open surgical biopsy. Further, the company sells, distributes, and services complementary products that are developed and manufactured by other original equipment manufacturers. Its customers include hospitals, imaging clinics, and private practices, as well as healthcare organizations and pharmaceutical companies. The company sells and services its products through a combination of direct sales and service force, and a network of independent distributors in the United States and Belgium. Hologic was founded by S. David Ellenbogen and Jay A. Stein. The company was incorporated in 1985 and is headquartered in Bedford, Massachusetts.
HORIZON HEALTH CORPORATION (HORC)
Horizon Health Corporation, doing business as Horizon Health, provides various health care services in the United States. The company operates through four segments: Behavioral Health Contract Management Services, Physical Rehabilitation Contract Management Services, Behavioral Health Hospital Services, and Employee Assistance Program Services. The Behavioral Health Contract Management Services segment offers various clinical behavioral health programs, including geropsychiatric, general adult, substance abuse, and child and adolescent programs for acute hospitals. These programs comprise crisis intervention, individual therapy, group and family therapy, recreational therapy, occupational therapy, lifestyle education, social services, and substance abuse counseling. The Behavioral Health Hospital Services segment a range of inpatient behavioral health care services for children, adolescents, and adults. The Physical Rehabilitation Services segment provides contract management services for various physical rehabilitation services to acute care hospitals. The Employee Assistance Program Services segment offers behavioral healthcare products to corporate customers, government agencies, and third party administrators. The company was founded in 1981 and is based in Lewisville, Texas.
ARRHYTHMIA RESEARCH TECHNOLOGY INC (HRT)
Arrhythmia Research Technology, Inc. (ART) engages in the development and licensing of medical software that acquires data and analyzes electrical impulses of the heart to detect and aid in the treatment of potentially lethal arrhythmias. Its products consist of Predictor 7 software, which is a Windows compatible version of Arrhythmia Research Technology's analytical program for the detection of late potentials. The company's customers include research institutions, hospitals, and clinics. Arrhythmia, through its wholly owned subsidiary, Micron Products, Inc., manufactures and distributes silver plated and nonsilver plated conductive resin sensors, and metal snap fasteners used in the manufacture of disposable integrated electrodes constituting a part of electrocardiographic diagnostic and monitoring instruments. It also manufactures and leases electrode assembly machines to its sensor and snap customers. The company markets its products through licensing with original equipment manufacturers. Arrhythmia was founded in 1981 and is based in Fitchburg, Massachusetts.
HealthTronics, Inc. engages in the provision of healthcare services; manufacture of medical devices primarily for the urology community; and manufacture and design of specialty vehicles used for the transport of medical, and broadcast and communications equipment primarily in the United States. It operates in three segments: Urology, Specialty Vehicle Manufacturing, and Medical Device Sales and Service. The Urology segment provides services related to the operation of lithotripters, including scheduling, staffing, training, quality assurance, regulatory compliance; and contracting with payors, hospitals, and surgery centers. These Lithotripters use extracorporeal shock waves to break up kidney stones into small pieces, which can pass naturally through the body's urinary tract. The Specialty Vehicle Manufacturing segment provides manufacturing services and installation, upgrade, refurbishment, and repair of medical equipment for mobile medical service providers, and the mobile broadcast and communication industry. This segment designs, constructs, and engineer mobile trailers, coaches, and special purpose mobile units that transport medical devices, such as magnetic resonance imaging, cardiac catheterization labs, CT scanware, lithotripters and positron emission tomography, and equipment designed for mobile command and control centers, as well as broadcasting and communications applications. The Medical Device Sales and Service segment manufactures, sells, and maintains lithotripters, as well as markets fixed and mobile tables for urological treatments and imaging; and patient handling tables for use by pain management clinics. HealthTronics is headquartered in Austin, Texas.
Humana, Inc., a health benefits company, offers health insurance coverage and related services through various Internet-based plans for employer groups, government-sponsored programs, and individuals in the United States. The company operates in two segments, Commercial and Government. The Commercial segment comprises members enrolled in products and includes three lines of business: fully insured medical, administrative services only (ASO), and specialty products. Fully insured medical products include consumer-directed products, including health maintenance organization (HMO) products, which provide prepaid health insurance coverage to its members through a network of independent primary care physicians, specialty physicians, and other health care providers; and preferred provider organization products that provide a member to choose a physician or other health care provider. ASO products are marketed to employers, who self-insure their employee health plans. Specialty products include dental, group and individual life, and short-term disability products. The Government segment consists of members enrolled in government-sponsored programs and includes three types of products: Medicare Advantage, which provides persons age 65 and over, and some disabled persons under the age of 65 certain hospital and medical insurance benefits; Medicaid, a federal program to enable the delivery of health care services to low-income residents; and TRICARE, which provides health insurance coverage to the dependents of active duty military personnel, and to retired military personnel and their dependents. The company offers its products and services primarily through independent brokers, agents, and sales representatives. As of December 31, 2004, it had approximately 7.0 million members in its medical insurance programs, as well as approximately 1.7 million members in its specialty products programs. Humana, Inc. was organized in 1964 and is headquartered in Louisville, Kentucky.
ICU Medical, Inc. engages in the development, manufacture, and marketing of disposable medical connection systems for use in intravenous (I.V.) therapy applications. Its products include CLAVE, a one-piece, needleless I.V. connection device; custom I.V. systems; Punctur-Guard line of blood collection needles; CLC2000, one piece, swabable connector used to connect I.V. lines to catheters; 1o2 Valve, a one-way or two-way drug delivery system; and Lopez Enteral Valve, a small T' valve designed to be connected into nasogastric, gastric, or jejunostomy tube systems. The company's devices are designed to protect healthcare workers and their patients from exposure to infectious diseases, such as Hepatitis B and C and Human Immunodeficiency Virus, through accidental needlesticks. In addition, the company develops a family of single-use needleless connectors for use in piggyback and nonpiggyback applications. ICU Medical sells its products to I.V. product manufacturers and independent distributors. It distributes its products in the United States, Canada, western Europe, the Pacific Rim, Latin America, and South Africa. ICU Medical was founded by George A. Lopez and is based in San Clemente, California.
I-FLOW CORPORATION (IFLO)
I-Flow Corporation engages in the design, development, manufacture, and marketing of ambulatory infusion systems for pain management and infusion therapy. It manufactures a line of infusion pumps, catheters, and pain kits that administer medication directly to the wound site, as well as administer local anesthetics, chemotherapies, antibiotics, diagnostic agents, nutritional supplements, and other medications. The company sells and distributes its products in the United States, Canada, Europe, Asia, Mexico, Brazil, Australia, New Zealand, and the Middle East. In addition, it engages in the rental of infusion pumps on a month-to-month basis for the treatment of cancer. I-Flow Corp. has a partnership with the University of Minnesota to conduct an animal study to evaluate the promise of antimicrobial benefits of ON-Q. The company was established in 1985 and is headquartered in Lake Forest, California.
ING CLARION GLOBAL REAL ESTATE INCOME FUND (IGR)
ING Clarion Global Real Estate Income Fund operates as a nondiversified, closed-end management investment company. The fund invests primarily in common and preferred stocks of the real estate companies. Its real estate investment portfolio primarily comprises buildings, shopping centers, warehouses, hotels, apartments, and malls. ING Clarion Real Estate Securities, L.P. serves as investment advisor of the fund. The fund was founded in 2003 and is based in Radnor, Pennsylvania.
IMPLANT SCIENCES CORPORATION (IMX)
Implant Sciences Corporation engages in the development, manufacture, and marketing of products for the medical device and explosives detection industry. Its core technology involves ion implantation and thin film coatings of radioactive and nonradioactive materials. The company manufactures and sells I-Plant Iodine-125 radioactive seed for the treatment of prostate cancer, and Ytterbium-192 for breast cancer therapy. It also provides surface engineering technology to manufacturers of orthopedic hip and knee total joint replacements. Implant Sciences has also developed a trace explosives detection instrument, which detects the vapor from trace amounts of explosive compounds, including plastic explosives, such as RDX, the compound commonly found in C4 explosives. The company also provides ion implantation, and analytical services and equipment to the semiconductor manufacturers, research laboratories, and research universities. In addition, it is developing a device for the treatment of ocular melanoma using brachytherapy, as well as other radiation therapy devices in various stages of development, including devices for biliary duct cancer and dural irradiation. The company has a strategic alliance with Rapiscan Systems, Inc. for the manufacture and sale of explosives detection equipment on a private label basis. Implant Sciences was incorporated in 1984 and is based in Wakefield, Massachusetts.
INTEGRAMED AMERICA INC (INMD)
IntegraMed America, Inc. offers fertility products and services to patients and providers in the fertility industry in the United States. It provides FertilityWeb, a Web site development, hosting, and marketing service that enables contracted fertility centers to develop and maintain transaction oriented Web site. The company also offers FertilityPurchase, a group purchasing program on disposable supplies, laboratory reagents, and capital equipment used by fertility centers in diagnosing and treating infertility; and FertilityMarKit, a package of marketing and sales programs, which include access to the company's proprietary marketing collateral material library of ads, brochures, fliers, and announcements. In addition, IntegraMed offers ARTWorks Clinical Information System, a system that provides clinical care to patients seeking fertility treatment; ARTWorks Practice Management Information System, which enables contracted fertility centers to have a scheduling, billing, and accounts receivable system; FertilityPartners, provides turnkey fertility center operation for contracted fertility centers. IntegraMed was incorporated in 1985 and is headquartered in Purchase, New York.
IRIDEX CORPORATION (IRIX)
IRIDEX Corporation engages in the development, manufacture, marketing, and sale of medical laser systems for the ophthalmic and aesthetic markets worldwide. The company provides semiconductor-based laser systems used to treat eye diseases in ophthalmology and skin conditions in dermatology. IRIDEX operates in two segments, Ophthalmology and Dermatology. The Ophthalmology segment develops, manufactures, and markets medical devices for the treatment of eye diseases, including the causes of irreversible blindness, age-related macular degeneration, diabetic retinopathy, and glaucoma. Its ophthalmology laser systems include IRIS Medical IQ810 Laser System, the OcuLight Symphony, OcuLight SL, OcuLight SLx, OcuLight GL, and OcuLight GLx laser photocoagulation systems used for ophthalmic applications primarily in hospitals, clinics, and doctors' offices. The Dermatology segment develops, manufactures, and markets medical devices to treat skin conditions, primarily vascular and pigmented lesions and remove unwanted hair. Its dermatology laser systems include the DioLite 532, the Apex 800, and the VariLite Dual Wavelength Laser systems primarily used in the practitioners' offices. The company sells its products to general ophthalmologists, as well as those specializing in retina, glaucoma and pediatrics, dermatologists, and plastic surgeons. Its other customers include research and teaching hospitals, government installations, surgi-centers, and hospitals. The company markets its products through direct sale force and distributors in the United States, as well as in Europe and the Asia/Pacific Rim region. IRIDEX Corporation was founded in 1989 under the name IRIS Medical Instruments, Inc. and changed its name to IRIDEX Corporation in 1996. The company is headquartered in Mountain View, California.
INTUITIVE SURGICAL INC (ISRG)
Intuitive Surgical, Inc. engages in the design, manufacture, and marketing of the da Vinci Surgical System for use in urologic, cardiothoracic, and general surgeries. The da Vinci Surgical System consists of a surgeon's console, a patient-side cart, and proprietary instruments. It translates the surgeon's natural hand movements on instrument controls at a console into corresponding micro-movements of instruments positioned inside the patient through small puncture incisions or ports. The system provides the surgeon with motion, fine tissue control, and 3-D vision characteristic of open surgery, while simultaneously allowing the surgeon to work through small ports. The company also manufactures various EndoWrist instruments, including forceps, scissors, electrocautery, scalpels, and other surgical tools, which incorporate a wrist joint with tips customized for various surgical procedures. Its other products include Aesop Endoscope Positioner, a voice-activated robotic arm that automates the critical task of endoscope positioning; and Hermes Control Center, a centralized system designed to voice control a series of networked smart medical devices. The company sells its products through direct sales force in the United States and Europe, as well as through distributors in Australia, Canada, India, Italy, Romania, Saudi Arabia, Singapore, Taiwan, and Turkey. Intuitive surgical was co-founded by John G. Freund, Frederic Moll, and Robert Younge in 1995. The company is headquartered in Sunnyvale, California.
INVACARE CORPORATION (IVC)
Invacare Corporation engages in the design, manufacture, and distribution of health care products. It offers rehab, standard, respiratory, distributed, and other products. Invacare's rehab products include power wheelchairs, custom manual wheelchairs, personal mobility, and seating and positioning products. The company's standard products include manual wheelchairs, personal care, home care beds, low air loss therapy products, and patient transport. Its respiratory products include oxygen concentrators, nebulizer compressors and respiratory disposables, sleep therapy products, and portable compressed oxygen systems. Invacare's distributed products include ostomy, incontinence, diabetic, wound care, and miscellaneous home medical products. Its other products include accessory products, such as spare parts, wheelchair cushions, arm rests, wheels, and respiratory parts. Invacare also manufactures and distributes beds and furnishings for the nonacute care markets. The company sells its products to home health care and medical equipment providers, as well as to government agencies and distributors. Invacare distributes its products through sales force, telesales associates, and independent manufacturers' representatives and distributors. The company was founded in 1885 and is headquartered in Elyria, Ohio.
KENSEY NASH CORPORATION (KNSY)
Kensey Nash Corporation, a medical technology company, engages in the development and manufacture of absorbable biomaterials-based products with applications in the cardiology, orthopaedics, spine, drug and biologics delivery, periodontal/dental, surgical, and wound care markets. It primarily offers Angio-Seal vascular closure device, a device designed to seal and close femoral artery punctures made during diagnostic and therapeutic cardiovascular catheterizations; and TriActiv embolic protection system, a device designed to prevent microparticulate from traveling downstream during the treatment of diseased coronary saphenous vein bypass grafts. This system utilizes active flushing and extraction to remove debris from the vessel after a treatment procedure. The company also develops various bone graft substitutes fabricated from collagen, synthetic polymers, or composite biomaterials. Kensey Nash has a strategic alliance with St. Jude Medical, Inc. The company was founded in 1984 and is based in Exton, Pennsylvania.
LAKELAND INDUSTRIES INC (LAKE)
Lakeland Industries, Inc. engages in the manufacture and sale of a line of safety garments and accessories for the industrial protective clothing market in the United States. Its products include limited use/disposable protective garments for protection from low-risk contaminants or irritants, such as chemicals, pesticides, fertilizers, paint, grease, and dust; chemical protective suits for protection from hazardous or potentially lethal chemical and biological toxins; fire fighting and heat protective apparel for use by fire fighters and other individuals; gloves and arm guards; and reusable woven garments. The company sells its products to safety and mill supply distributors, as well as to governmental agencies and departments through own sales force and independent sales representatives. Lakeland Industries was co-founded by Raymond J. Smith. The company was organized in 1982 and is headquartered in Ronkonkoma, New York.
LCA-Vision, Inc. engages in the development and operation of fixed-site laser vision correction centers under LasikPlus brand primarily in the United States. The company's vision centers provide staff, facilities, equipment, and support services for performing laser vision correction that employs laser technologies to help and correct nearsightedness, farsightedness, and astigmatism. Its vision centers are supported mainly by certified ophthalmologists and optometrists, as well as other health care professionals. As of December 12, 2005, the company owned and operated 50 LasikPlus fixed-site laser vision correction centers in the United States and a joint venture in Canada. LCA-Vision was founded in 1985 and is headquartered in Cincinnati, Ohio.
LABORATORY CORPORATION OF AMERICA HOLDINGS (LH)
Laboratory Corporation of America Holdings, together with its subsidiaries, operates as an independent clinical laboratory company in the United States. It offers a range of clinical laboratory tests, which are used by the medical profession in routine testing, patient diagnosis, and in the monitoring and treatment of disease. The company offers routine testing services, such as blood chemistry analyses, urinalyses, blood cell counts, Pap tests, HIV tests, microbiology cultures and procedures, and alcohol and other substance-abuse tests. It also offers specialty services, including allergy testing; clinical trials testing; oncology testing in which it diagnoses and monitors certain cancers, and predicts the outcome of certain treatments; HIV genotyping and phenotyping; diagnostic genetics that include cytogenetic, molecular cytogenetic, biochemical, and molecular genetic tests; and urine and blood testing services for the detection of drug and alcohol abuse. In addition, the company provides anatomic pathology testing services in uropathology, dermatopathology, GI pathology, and hematopathology areas. It offers its services through a combination of direct sales generalists and specialists to physicians, hospitals, HMOs and other managed care organizations, governmental agencies, large employers, and other independent clinical laboratories. As of December 31, 2004, the company had 32 primary laboratories and approximately 1,300 service sites, consisting of branches, patient service centers, and STAT laboratories. Laboratory Corporation of America was founded in 1971 and is headquartered in Burlington, North Carolina.
LUMINEX CORPORATION (LMNX)
Luminex Corporation engages in the design, development, manufacture, and marketing of proprietary biological testing technologies with applications throughout the life sciences industry. The company's xMAP technology enables its Luminex 100 System to simultaneously perform up to 100 bioassays on a single drop of fluid by reading biological tests that are taking place on the surface of microscopic polystyrene beads called microspheres. The xMAP technology is used in various segments of the life sciences industry, including the fields of drug discovery and development, clinical diagnostics, genetic analysis, protein analysis, and biomedical research. The company's customers include clinical diagnostic, pharmaceutical, biotechnological, and chemical companies. Luminex Corp. has an agreement with Biohit Oyj for the development and commercialisation of a diagnostic test system segment. The company was incorporated in 1995 and is based in Austin, Texas.
LINCARE HOLDINGS INC (LNCR)
Lincare Holdings, Inc. provides oxygen and other respiratory therapy services to patients in the home, in the United States. Its customers typically suffer from chronic obstructive pulmonary disease, such as emphysema, chronic bronchitis, or asthma, and require supplemental oxygen or other respiratory therapy services. The company offers oxygen delivery equipment, such as oxygen concentrators and liquid oxygen systems, as well as other respiratory therapy services, including nebulizers and associated respiratory medications, noninvasive ventilation, ventilators, and continuous positive airway pressure devices. It also offers home infusion therapies, including parenteral nutrition, intravenous antibiotic therapy, enteral nutrition, chemotherapy, dobutamine infusions, immunoglobulin therapy, continuous pain management, and central catheter management. In addition, Lincare supplies home medical equipment, such as hospital beds, wheelchairs, and other supplies. Lincare Holdings is headquartered in Clearwater, Florida.
LIFEPOINT HOSPITALS INC (LPNT)
LifePoint Hospitals, Inc. operates general and acute care hospitals in nonurban communities in the United States. Its hospitals provide a range of medical and surgical services, including diagnostic and emergency services; and outpatient and ancillary services, such as outpatient surgery, laboratory, radiology, respiratory therapy, and physical therapy. The company operated 53 hospitals primarily in Alabama, Florida, Kansas, Kentucky, Louisiana, Tennessee, Utah, West Virginia, and Wyoming, as of November 18, 2005. LifePoint Hospitals was formed in 1997 and is headquartered in Brentwood, Tennessee.
LUXOTTICA GROUP S.P.A (LUX)
Luxottica Group S.p.A engages in the design, manufacture, and distribution of prescription frames and sunglasses in the mid-and premium-price categories. The company operates in two segments, Manufacturing and Wholesale Distribution, and Retail Distribution. The Manufacturing and Wholesale Distribution segment engages in the design, manufacture, wholesale distribution, and marketing of house brand and designer lines prescription frames and sunglasses. The Retail Distribution segment operated a retail network of approximately 880 locations, which offer a various prescription frames, sunglasses, lenses, and other optical products in the North American market; operated approximately 1,850 retail locations that offer watches in North America, Europe, and Australia; operated a chain of personalized gift stores, e-commerce, and catalogs under the name Things Remembered; and operated 36 stores in New Zealand, 74 stores in Hong Kong, 9 stores in Singapore, and 13 stores in Malaysia, as of December 31, 2004. The company was established by Leonardo Del Vecchio in 1961 and is headquartered in Milan, Italy.
MATRIA HEALTHCARE INC (MATR)
Matria Healthcare, Inc. provides disease management services and related products for medical conditions and chronic diseases, including diabetes, cardiovascular diseases, respiratory disorders, obstetrical conditions, cancer, obesity, depression, chronic pain, and hepatitis C. The company operates in two segments, Health Enhancement, and Women's and Children's Health segment. The Health Enhancement segment offers disease management services to employers and health plans for diabetes, cardiovascular disease, respiratory disorders, cancer, obesity, depression, and chronic pain. It also provides diabetes products and supplies, and certain other services directly to patients in Germany. In addition, Health Enhancement segment designs, develops, assembles, and distributes three primary product lines used by patients with diabetes to obtain blood samples for testing blood glucose levels, which include standard lancets, lancing devices, and safety lancets. The Women's and Children's Health segment offers a range of clinical and disease management services to enable physicians and payors manage maternity patients. It manages patients with gestational diabetes, hypertension, hyperemesis, and anticoagulation disorders, as well as patients experiencing or at risk for preterm labor. The company also provides online health and wellness solutions; and design, development, and manufacturing services to original equipment manufacturers in the in-vitro diagnostic, medical, and drug delivery industries. It offers its services to self-insured employers, private and government sponsored health plans, pharmaceutical companies, and patients. The company operates in North and South America, Europe, and Asia. Matria Healthcare is headquartered in Marietta, Georgia.
MEDICAL ACTION INDUSTRIES INC (MDCI)
Medical Action Industries, Inc. engages in the development, manufacture, marketing, and supply of medical and surgical disposable products. It also manufactures and supplies collection systems for the containment of medical waste; minor procedure kits and trays; and sterile operating room towels and sterile laparotomy sponges. The company sells its products principally in the United States to acute care facilities; physician, dental, and veterinary offices; out-patient surgery centers; and long-term care facilities. Its products are marketed by its direct sales personnel, distributors, and manufacturers' representatives. In addition, the company manufactures its products under private label programs to other distributors and medical suppliers. Medical Action Industries was incorporated in 1977 and is headquartered in Hauppauge, New York.
Medtronic, Inc. engages in the development and manufacture of medical devices for the treatment of various diseases. Cardiac Rhythm Management segment offers implantable devices, external defibrillators, leads, ablation products, electrophysiology catheters, navigation systems, and information systems for heart rhythm disorders and heart failure. Spinal, Ear, Nose, and Throat and Surgical Navigation Technologies segment provides thoracolumbar cervical and interbody, and spinal devices; bone growth substitutes; surgical navigation tools; and surgical products for spinal, ear, nose, and throat disorders. Neurological and Diabetes segment offers implantable neurostimulation systems, external and implantable drug administration devices, neurosurgery products, urology products, gastroenterology products, hydrocephalic shunts and drainage devices, surgical instruments, functional diagnostic and sensing equipment, and medical systems for neurological disorders, diabetes, gastroentrological disorders, and urological disorders. Vascular segment provides coronary, endovascular, and peripheral stents and related delivery systems; stent graft systems; distal embolic protection systems; and balloon angioplasty catheters, guide catheters, guidewires, and diagnostic catheters and accessories for coronary artery disease, peripheral vascular disease, and aortic aneurysms. Cardiac Surgery segment offers positioning and stabilization systems for beating heart surgery; perfusion systems; products for the repair and replacement of heart valves; surgical accessories; and epicardial ablation products. The company sells its products to physicians, hospitals, medical institutions, and group purchasing organizations worldwide, through direct sales representatives and independent distributors. Medtronic was founded in 1949 by Earl E. Bakken and Palmer J. Hermundslie. The company is headquartered in Minneapolis, Minnesota.
MDS, Inc., a health and life sciences company, engages in the development of drugs and management of disease in the North America. It operates through two segments, Life Sciences and Health business. The Life Sciences segment supplies products and services, such as pharmaceutical contract research services, medical isotopes, and advanced analytical equipment to manufacturers of medical products, such as pharmaceuticals, medical devices, and supplies. The Health business segment provides products and services, such as clinical laboratory testing and distribution of medical products to individuals and to institutions that provide health care services to consumers. The company's customers include pharmaceutical and biotechnology companies, and health care providers, such as doctors and hospitals. MDS was founded in 1969 as Medical Data Sciences Limited and changed its name to MDS Health Group Limited in 1973. Further it changed its name to MDS, Inc. in 1996. The company is based in Toronto, Canada.
MESA LABORATORIES INC (MLAB)
Mesa Laboratories, Inc. engages in the design, manufacture, and marketing of electronic instruments and supplies. Its product line consists of recording systems, which are used to measure temperature, humidity, and pressure inside a process or inside a product during manufacturing; fluid measurement components, such as flow meters, used in water treatment, chemical processing, and heating, ventilation, and air conditioning applications; and concentration analyzers and pipeline interface detectors, which are used in chemical, food, pharmaceutical, and polymerization processes. The company also manufactures and distributes electronic measurement systems for renal treatment, including dialysate meters and dialyzer reprocessing products used in kidney dialysis. Mesa Laboratories was incorporated in 1982 and is based in Lakewood, Colorado.
MERIT MEDICAL SYSTEMS INC (MMSI)
Merit Medical Systems, Inc. (MMS) engages in the development, manufacture, and marketing of disposable medical products primarily for use in the diagnosis and treatment of cardiovascular disease in the United States. The company's products consist of coronary control syringes; inflation devices and monitors; specialty syringes; high-pressure tubing and connectors; waste management products; disposable blood pressure transducer and pressure monitoring tubing; disposable hemostasis valves and accessories, and guide wire torque devices; manifolds and stopcocks; radial artery compression systems; contrast management systems; angiography needles and accessories; drainage catheters and accessories; pericardiocentesis catheters and procedure trays; thrombolytic infusion catheters and accessories; diagnostic angiographic pigtail catheters, diagnostic cardiology and radiology catheters, and marker band catheters; guide catheters; sheath introducers, vessel dilators, fixed and movable core, diagnostic guide wires and accessories, and hydrophilic guide wires; pressure infusor bags; and procedure trays. It serves hospital-based cardiologists, radiologists, anesthesiologists, physiatrists, neurologists, technicians, and nurses. MMS was founded by Fred P. Lampropoulos and Kent W. Stanger in 1987. The company is headquartered in South Jordan, Utah.
Morgan Stanley, a financial services company, through its subsidiaries and affiliates, provides various products and services to a range of clients and customers, including corporations, governments, financial institutions, and individuals. The company operates in four segments: Institutional Securities, Individual Investor Group, Investment Management, and Credit Services. The Institutional Securities segment provides investment banking services, including securities underwriting and distribution; and financial advisory services, which include advice on mergers and acquisitions, restructurings, real estate, and project finance. It also engages in selling, trading, financing, and market-making activities in equity securities and related products, and fixed income securities and related products, including foreign exchange and commodities, as well as in other activities, such as real estate investment management, aircraft financing, benchmark indices and risk management analytics, and research. Individual Investor Group segment offers brokerage, investment, and financial services designed to accommodate individual investment goals and risk profiles. The Investment Management segment provides asset management products and services, such as open- and closed-end funds, and separately managed accounts, as well as investment management products and services for individual and institutional investors primarily through its representatives, third-party broker-dealers, banks, financial planners, and other intermediaries. The Credit Services segment provides credit cards, consumer finance products and services, including residential mortgage loans; and a network of merchant and cash access locations primarily in the United States. Morgan Stanley was founded in 1935 and is headquartered in New York City.
MINE SAFETY APPLIANCES COMPANY (MSA)
Mine Safety Appliances Company engages in the development, manufacture, and supply of equipment and systems for worker and plant protection in North America, Europe, and internationally. The company primarily operates in two divisions, Safety Products and Instruments. The Safety Products division offers personal protective products, such as filtering respirators, self-contained breathing apparatus, hard hats, clothing, hearing protectors, nonprescription protective eyewear and face shields, and fire and military helmets. The Instrument division offers hand-held and permanent instruments, including gas detection instruments, thermal imaging cameras, and flame detectors and open-path infrared gas detectors. It also offers fall protection equipment, such as confined space equipment, harnesses/fall arrest equipment, lanyards, and lifelines. The company's products are used in the fire service, homeland security, construction, and other industries, as well as by the military. Mine Safety Appliances Company was established in 1914 and is headquartered in Pittsburgh, Pennsylvania.
NATIONAL DENTEX CORPORATION (NADX)
National Dentex Corporation engages in the design, fabrication, marketing, and sale of dental prosthetic appliances for dentists in the United States. As of June 30, 2005, the company owned and operated 45 dental laboratories in 30 states, which design and fabricate dentures, crowns and fixed bridges, and other dental appliances. Its products are grouped into three main categories: Restorative, Reconstructive, and Cosmetic. The Restorative group includes gold or porcelain made crowns and bridges, which are permanently affixed to a patients' existing dental anatomy. Its Reconstructive products are removable prosthesis that replace missing teeth and associated structures, including partial and full dentures. The company's Cosmetic group consists primarily of porcelain veneers used to enhance the appearance of the front of a tooth, as well as various ceramic crowns that replicate the appearance of natural teeth. This category also includes composite inlays and onlays, which replace silver fillings for a natural appearance; and orthodontic appliances, which are products fabricated to move existing teeth to enhance function and appearance. National Dentex sells its products primarily through its own direct sales force. The company was founded in 1982 as H&M Laboratories Services, Inc. and changed its name to National Dentex Corporation in 1983. National Dentex is headquartered in Wayland, Massachusetts.
NEUROCRINE BIOSCIENCES INC (NBIX)
Neurocrine Biosciences, Inc. engages in the discovery and development of drugs for the treatment of neurological and endocrine-related diseases and disorders in the United States. Its product candidates address various pharmaceutical markets, including insomnia, anxiety, depression, various female and male health disorders, multiple sclerosis, diabetes, and other neurological and endocrine related diseases and disorders. Neurocrine has 17 programs in various stages of research and development. Its lead clinical development program, indiplon, for the treatment of insomnia, partnered with Pfizer, Inc., is in Phase III clinical development. The company completed three Phase I single and multiple dose trials with Gonadotropin-releasing Hormone, GnRH, for the treatment of women's health disorders. It also has two Altered Peptide Ligand products in Phase II clinical development, NBI-5788 for multiple sclerosis and NBI-6024 for Type I Diabetes. Neurocrine initiated a Phase I clinical trial with its proprietary compound, urocortin 2 for treating mild to moderate congestive heart disease. The company's CRF program, partnered with GlaxoSmithKline, is developing multiple compounds that are in various stages of research and preclinical development. It also has strategic alliances with Almirall Prodesfarma, S.A.; Wyeth Holdings Corporation; and Eli Lilly and Company. The company was incorporated in 1992 and is headquartered in San Diego, California.
NATIONAL HEALTHCARE CORPORATION (NHC)
National HealthCare Corporation (NHC) operates long-term health care centers with associated assisted living and independent living centers primarily in the southeastern United States. The company's health care services include a range of services through related or separately structured long-term health care centers, specialized care units, pharmacy operations, rehabilitative services, assisted living centers, retirement centers, and homecare programs. It also offers professional health services that include physical, speech, and occupational therapies. The company also provides center-specific medical specialty units, such as Alzheimer's disease care units and subacute nursing units. In addition, NHC owns, leases, or manages assisted living projects, offering basic room and board functions for the elderly with the on-staff availability to assist in minor medical needs. Additionally, the company offers management, accounting and financial, and insurance services to its customers. As of September 30, 2005, the company managed 74 long-term health care centers with a total of 9,177 licensed beds. It also operated 31 homecare programs, 6 independent living centers, and 22 assisted living centers, as of the above date. NHC was founded in 1971 and is based in Murfreesboro, Tennessee.
NATIONAL MEDICAL HEALTH CARD SYSTEMS INC (NMHC)
National Medical Health Card Systems, Inc. (NMHC) provides pharmacy benefit management services to managed care organizations, local governments, unions, corporations, and third party health care plan administrators through its network of licensed pharmacies in the United States. The company's pharmacy benefit management services include electronic point-of-sale pharmacy claims management, retail pharmacy network management, mail service pharmacy claims management, specialty pharmacy claims management, benefit design consultation, preferred drug management programs, drug review and analysis, consulting services, disease information services, data access, reporting and information analysis, and physician profiling. In addition, NMHC operates a mail service pharmacy, a specialty pharmacy, and health informatics company. It sells its products and services through direct sales force. The company has service centers in Little Rock, Arkansas; Sacramento, California; Portland, Maine; Miramar, Florida; Latham, New York; and Dallas, Texas. NMHC was founded in 1981 and is headquartered in Port Washington, New York.
NMT Medical, Inc. engages in designing, developing, and marketing proprietary implant technologies that allow cardiologists to treat cardiac sources of migraine headaches, stroke, and other brain attacks through minimally invasive, catheter-based procedures. The company designs and develops implants that seal the patent foramen ovale defect. It also offers cardiac septal repair implants delivered with nonsurgical catheter techniques. The company manufactures CardioSEAL, a cardiac septal repair implant; and STARFlex, which incorporates a self-centering system that enables the implant to self-adjust to variations in the anatomy of a septal defect without deforming the septum or interfering with heart valve function. NMT Medical markets CardioSEAL through its direct sales force to customers in the United States and Canada, and markets CardioSEAL and STARFlex directly and through distributors in Europe. In addition, the company sells third party products for use with the CardioSEAL and STARFlex implant devices, principally vascular sizing balloons and sheaths. NMT Medical was co-founded by Morris Simon in 1986 and is headquartered in Boston, Massachusetts.
ORTHOFIX INTERNATIONAL N.V (OFIX)
Orthofix International N.V. primarily engages in the design, development, manufacture, marketing, and distribution of medical equipment for the orthopedic products market. Its products include external and internal fixation devices used in fracture treatment, limb lengthening, and bone reconstruction; noninvasive stimulation products for spinal fusions and to treat nonunion fractures; and bracing products used for ligament injury prevention, pain management, and protection of surgical repair to promote faster healing. The company's products also include a device for improving venous circulation, cold therapy, other pain management products, bone cement and devices for removal of the bone cement used to fix artificial implants, and airway management products used in anesthesia applications. Orthofix International offers its orthopedic products primarily to spine, reconstruction, and trauma sectors. It distributes products directly and indirectly through independent distributors in the United States, the United Kingdom, Ireland, Italy, Germany, Switzerland, Austria, France, Belgium, Mexico, Brazil, and Puerto Rico. The company was founded in 1979 and is based in Curacao, the Netherlands.
Orthologic Corp., a drug development company, engages in healing musculoskeletal, orthopedic, dermal, and cardiovascular tissues through biopharmaceutical approaches. The company develops Chrysalin, or TP508, a 23-amino acid synthetic peptide that stimulates body's natural healing processes. It also develops Chrysalin-based product candidates, which are in preclinical trials and are used for fractures, healing diabetic foot ulcers, spinal instability, cartilage defect repair, cardiovascular repair, dental bone repair, and ligament and tendon repair. In addition, the company's product development pipeline includes Chrysalin-based product candidates for spinal fusion, dental bone formation, and myocardial revascularization. Orthologic Corp. was incorporated in 1987. It was formerly known as IatroMed, Inc. and changed its name to Orthologic Corp. in 1991. The company is headquartered in Tempe, Arizona.
OSI PHARMACEUTICALS INC (OSIP)
OSI Pharmaceuticals, Inc., a biotechnology company, engages in the discovery, development, and commercialization of oncology products for cancer patients in the United States. Its flagship product, Tarceva, is an oral, once-a-day, small molecule inhibitor of the epidermal growth factor receptor. The company also markets Novantrone for the approved oncology indications; and Gelclair for the relief of pain associated with oral mucositis. Its other drug candidates include OSI-7904L, a liposomal formulation of a potent thymidylate synthase inhibitor, which is in phase II study; OSI-461, an inhibitor of cGMP phosphodiesterases, which is in phase I dose optimization study; and OSI-930, a tyrosine kinase inhibitor, which is in preclinical research stage. In addition, OSI Pharmaceuticals, through its collaborative drug discovery program, develops CP-547,632, which targets vascular endothelial growth factor receptor and is in Phase II and Phase I trials; CP-868,596 that targets tumor derived angiogenesis and is in Phase I trials; and CP-724,714, which is an oral inhibitor of epidermal growth factor receptor 2 and is in Phase I clinical trial. Further, its subsidiary, Prosidion Limited, specializes in diabetes and obesity treatment in the United Kingdom. The company has collaboration agreements with Pfizer, Inc.; Cold Spring Harbor Laboratory; EiRX Therapeutics plc; Genentech, Inc.; PR Pharmaceuticals, Inc.; and Roche. OSI Pharmaceuticals is headquartered in Melville, New York.
Osteotech, Inc. engages in processing human bone and connective tissue for transplantation, as well as development, manufacture, and marketing of biologic, biomaterial, and device systems for musculoskeletal surgery. It focuses on spinal, trauma, and total joint revision procedures. The company provides services, and develops, markets, and sells products to the orthopaedic, neurological, oral/maxillofacial, and general surgery markets in the United States and Europe. It offers demineralized bone grafts, structural allografts, and other allografts. The company's demineralized bone matrix and base tissue processing yields various freeze-dried, frozen, and demineralized allograft bone tissue forms that are used by orthopaedic, neurological, plastic, periodontal, and oral/maxillofacial surgeons. Its products are used for spinal fusion procedures; repair and replacement of bone loss caused by trauma or certain disease states; augmentation of prosthetic implant procedures; and replacement of damaged ligaments and tendons. The company processes and develops human bone and bone connective tissue, or allograft bone tissue forms. It also processes, markets, and distributes bovine bone tissue products, which are utilized as bone graft substitutes by surgeons in Europe, Asia, and the Middle East. The company was formed in 1986 and is based in Eatontown, New Jersey.
PHARMACOPEIA DRUG DISCOVERY INC (PCOP)
Pharmacopeia Drug Discovery, Inc., a biopharmaceutical company, engages in the discovery and development of small molecule therapeutics primarily to address significant medical needs. Using proprietary technologies and processes, Pharmacopeia discovers and develops novel drug candidates to advance internally, as well as with strategic partners. Pharmacopeia's product pipeline includes four compounds in human clinical trials (all Phase I) with various partners, including a compound targeting rheumatoid arthritis in collaboration with Bristol Myers Squibb, a compound targeting asthma and allergies in collaboration with Daiichi Pharmaceutical Corporation, a compound targeting respiratory diseases in collaboration with Schering-Plough, and a compound targeting inflammation in collaboration with Schering-Plough. The company also has 6 additional partnered compounds in preclinical development; 4 internal (nonpartnered) drug candidates; and approximately 20 partnered and internal discovery-stage programs. Pharmacopeia was founded in 1993 and is headquartered in Cranbury, New Jersey.
PEDIATRIX MEDICAL GROUP INC (PDX)
Pediatrix Medical Group, Inc. and its subsidiaries provide neonatal, maternal-fetal, and other pediatric subspecialty physician services in the United States and Puerto Rico. The company provides clinical care within hospital-based neonatal intensive care units to babies born prematurely or with medical complications. It offers outpatient and inpatient clinical care to expectant mothers experiencing complicated pregnancies and their unborn babies through its affiliated maternal-fetal medicine subspecialists and other clinicians, such as maternal-fetal nurses, certified mid-wives, ultrasonographers, and genetic counselors. The company's other pediatric subspecialty care include a network of pediatric subspecialists, such as pediatric intensivists for critically-ill or injured children and adolescents; pediatric cardiologists for congenital and acquired heart disorders; and pediatric hospitalists for inpatient care and management of acutely-ill children. Its affiliated physicians also provide clinical services in other areas of hospitals, particularly in the labor and delivery area, nursery, and pediatric department. The company also offers newborn screening program, which identifies approximately 50 metabolic disorders, and genetic and biochemical conditions, and potential hearing loss for early treatment or management. In addition, it offers newborn screening program, which identifies approximately 50 metabolic disorders, genetic and biochemical conditions, and potential hearing loss for early treatment or management. As of December 31, 2004, the company employed approximately 776 physicians, including 603 neonatal physician specialists providing clinical care in 31 states and Puerto Rico. Pediatrix was co-founded by Roger Medel and Greg Melnick in 1979. The company is based in Sunrise, Florida.
PANHANDLE ROYALTY COMPANY (PHX)
Panhandle Royalty Company engages in the acquisition and management of fee mineral acreage, and the exploration for and development of oil and gas properties. The company produces crude oil and natural gas. As of September 30, 2005, its proved reserves included 634,323 barrels of oil and 27,446,403 Mcf of gas. The company serves pipeline and marketing companies through the operators of the wells. Panhandle Royalty was founded as Panhandle Cooperative Royalty Company in 1926 and is based in Oklahoma City, Oklahoma.
PSYCHEMEDICS CORPORATION (PMD)
Psychemedics Corporation provides testing services for the detection of abused substances through the analysis of hair samples. Its testing methods utilize a patented technology for performing immunoassays on enzymatically dissolved hair samples with confirmation testing by mass spectrometry. The company offers commercial testing and confirmation by mass spectrometry using industry-accepted practices for cocaine, marijuana, PCP, methamphetamine, and opiates. Psychemedics' tests provides quantitative information, which indicates the approximate amount of drug ingested, as well as historical data, which can show a pattern of individual drug use over a period of time. Its information is useful to employers, physicians, treatment professionals, law enforcement agencies, schools, and parents concerned about drug use by their children, as well as other individuals and entities. The company also offers PDT-90, a personal drug testing service for parents concerned about drug use by their children. Psychemedics markets its corporate drug testing services through own sales force; and PDT-90 through the Internet and retail distributors in the United States. The company was founded in 1985 and is based in Acton, Massachusetts.
POSSIS MEDICAL INC (POSS)
Possis Medical, Inc. engages in the development, manufacture, and marketing of medical devices for the cardiovascular and vascular treatment markets. Its primary product is AngioJet Rheolytic Thrombectomy System, a nonsurgical, minimally invasive catheter system used for blood clot removal from native coronary arteries, leg arteries, coronary bypass grafts, and AV dialysis access grafts. The company offers its system to interventional cardiologists, interventional radiologists, vascular surgeons, nephrologists, and osteopaths. It also offers XMI, XMI-RX, XMI RX +, Spiroflex, XVG, Xpeedior, DVX, and AVX line of catheters. The company was founded in 1952 and is headquartered in Minneapolis, Minnesota.
PHARMACEUTICAL PRODUCT DEVELOPMENT INC (PPDI)
Pharmaceutical Product Development, Inc. (PPD) and its subsidiaries provide drug discovery and development services, and products primarily in the United States and Europe. The company operates in two segments, Development and Discovery Sciences. Its Development segment provides various services, which include preclinical programs and phase I to phase IV clinical development services. It also offers post-market support services, such as product launch services, patient compliance programs, disease registry programs, and medical communications programs for consumer and healthcare providers on product use and adverse events. The Discovery Sciences segment engage in preclinical evaluations of anticancer therapies and compound partnering arrangements associated with the development and commercialization of drug products. The company provides a range of discovery and development services, and products to enable pharmaceutical, biotechnology, and medical device companies develop compounds, drugs, and devices. It offers its products and services in 28 countries worldwide. Pharmaceutical Product Development has a joint develop agreement with Falco Biosystems, Ltd. to develop diagnostic products for the detection of renal cell carcinoma. The company was founded in 1985 and is headquartered in Wilmington, North Carolina.
Respironics, Inc. engages in the design, development, manufacture, and marketing of medical devices used primarily for the treatment of patients suffering from sleep and respiratory disorders. Its products are used primarily in the home and in hospitals, as well as emergency medical settings and alternative care facilities. The company's primary product lines include homecare products and hospital products. Its homecare products include sleep apnea products, including continuous positive airway pressure devices and bi-level positive airway pressure devices used in the home for the treatment of obstructive sleep apnea; respiratory devices, including bi-level noninvasive ventilation products that provide positive airway pressure into a patient's airway to supplement the patient's own breathing; invasive portable volume ventilation products used in the home; and home oxygen products. The company's hospital products include therapeutic devices that assist or control a patient's ventilation, such as bi-level noninvasive ventilation products and critical care ventilation products that can deliver noninvasive and invasive ventilation; cardio-respiratory monitoring products that provide information about a patient's condition; and traditional respiratory drug delivery products. In addition, the company offers respiratory drug delivery products, and children's medical ventures infant management and developmental care products. It sells its products to home medical equipment service providers and hospital distributors located in Europe, Africa, the Middle East, Latin America, the Far East, and Asia Pacific. The company markets its products through homecare, hospital, respiratory drug delivery, and international sales organizations. Respironics was founded in 1976 and is based in Murrysville, Pennsylvania.
REHABCARE GROUP INC (RHB)
Rehabcare Group, Inc. provides rehabilitation program management services for hospitals, nursing homes, and other long term care facilities. It operates in two segments, Program Management Services and Healthcare Management Consulting. The Program Management Services segment operates inpatient acute rehabilitation units for patients with diagnoses, such as stroke, orthopedic conditions, arthritis, spinal cord, and traumatic brain injuries. Its outpatient therapy programs provide management of therapy services to patients with work-related and sports-related illnesses and injuries. This segment also offers contract therapy services, including rehabilitation services in freestanding skilled nursing, long term care, and assisted living facilities for neurological, orthopedic and other medical conditions. The Healthcare Management Consulting segment offers strategic and financial planning, performance improvement, physicians' services, and revenue cycle services for healthcare providers. Its customers include hospitals, nursing homes, and other long-term care facilities located in 37 states in the United States, the District of Columbia, and Puerto Rico. RehabCare Group was established in 1982 and is based in St. Louis, Missouri.
RIGEL PHARMACEUTICALS INC (RIGL)
Rigel Pharmaceuticals, Inc. engages in the discovery and development of small-molecule product candidates for the treatment of unmet medical needs. It has three product development programs, such as allergy/asthma, rheumatoid arthritis, and cancer. The company develops R112, which is in Phase II clinical trial for the treatment of allergic rhinitis; and R406/788 that is in Phase I clinical study for the treatment of rheumatoid arthritis. Rigel's another product candidate R406 is in preclinical studies, which is an oral Syk kinase inhibitor that blocked the activation of mast cells and B cells that promote the swelling and inflammatory response. It has collaboration agreements with Janssen Pharmaceutica N.V.; Pfizer, Inc.; Novartis Pharma AG; Daiichi Pharmaceuticals Co., Ltd.; and Merck and Co., Inc. Rigel was incorporated in 1996 and is based in South San Francisco, California.
RITA MEDICAL SYSTEMS INC (RITA)
RITA Medical Systems, Inc. engages in the development, manufacture, and marketing of products that use radiofrequency energy to treat patients with cancerous or benign tumors. It offers radiofrequency ablation systems for treating cancerous tumors, as well as percutaneous vascular ports and specialty access catheters (SAC). The company's radiofrequency ablation (RFA) system consists of disposable devices and generators. RITA's RFA system delivers radiofrequency energy to raise the temperature of affected cells above 45 to 50°C, causing cellular death. Its vascular access ports are implantable devices utilized for the central venous administration of various medical therapies, and for blood sampling and diagnostic purposes. In addition, the company manufactures and markets SAC products, including hemodialysis catheters, central venous catheters, needle infusion sets, peripherally inserted central venous catheters, and other accessories used in vascular procedures. RITA's customers primarily include surgical oncologists, hepatobiliary surgeons, liver transplant surgeons, laparoscopists, and interventional radiologists, as well as colorectal surgeons, radiation oncologists, and medical oncologists. It markets products through a direct sales force and distributors in the United States, and through distribution partners in Europe and Asia. The company was founded in 1994 and is headquartered in Fremont, California.
ResMed, Inc., through its subsidiaries, engages in the design, manufacture, and marketing of equipment for the diagnosis and treatment of sleep-disordered breathing and other respiratory disorders, including obstructive sleep apnea. Its products include airflow generators; diagnostic products; mask systems; headgear; and other accessories, including humidifiers, cold passover humidifiers, carry bags, breathing circuits, Twister remote, the Aero-Click connection system, and the AeroFix headgear. The company markets its products through a network of distributors, independent manufacturers' representatives, and direct sales force. ResMed has strategic alliances with Guidant Corporation and MedCath Corporation. The company was founded in 1989 and is based in Poway, California.
ROCHESTER MEDICAL CORPORATION (ROCM)
Rochester Medical Corporation engages in the development, manufacture, and marketing of various latex-free and PVC free urinary continence, and urine drainage care products for the home care, extended care, and acute care markets. The company's extended care products include a line of male external catheters for managing male urinary incontinence and a line of intermittent catheters for managing both male and female urinary retention. The extended care products also include the FemSoft Insert, a soft, liquid-filled, and conformable urethral insert for managing female stress urinary incontinence in adult females; and Personal Catheters, a line of disposable intermittent catheters manufactured from silicone for male, female, and pediatric use and in multiple diameters. Its acute care products include a line of standard Foley catheters; and Release-NF Catheter, an antibacterial Foley catheter that reduces the incidence of hospital acquired urinary tract infection. The company also offers standard silicone Foley catheters in a two-lumen version for urinary drainage management and in a three-lumen version that also supports irrigation of the urinary tract. In addition, it manufactures and sells male external catheters made from proprietary nonlatex, nonsilicone material to certain private label customers. The company markets its products through a direct sales force in the United States and independent distributors in international markets. Rochester Medical Corporation was founded in 1988 and is based in Stewartville, Minnesota.
Res-Care, Inc. provides residential, therapeutic, job training, and educational support services to people with special needs. It operates in three segments: Disabilities Services, Youth Services, and Training Services. The Disabilities Services segment provides periodic in-home services, group homes, supported living, residential facilities, and vocational skills training and day programs. The Youth Services segment offers educational, behavioral, and vocational training, including individual, group, and family counseling and training in social and independent living skills to at-risk and troubled youths. The Training Services segment operates programs for disadvantaged youths through the federal Job Corps program administered by the United States Department of Labor, which provides educational and vocational skills training, health care, employment counseling, and other support. The company offered its services to approximately 34,000 people in 33 states, Washington, D.C., Puerto Rico, and Canada, as of February 25, 2005. Res-Care was founded by Jim Fornear in 1974 and is based in Louisville, Kentucky.
STRATEGIC DIAGNOSTICS INC (SDIX)
Strategic Diagnostics, Inc. engages in the development, manufacture, and marketing of antibody products and analytical test kits for a range of food, water, agricultural, industrial, environmental, and scientific applications primarily in the United States. It primarily focuses on immunology, proteomics, bio-luminescence, and other bio-reactive technologies. The company offers monoclonal and polyclonal antibody products and services in the areas of hybridoma development, cell culture techniques, large-scale ascites and antisera production, large-scale antibody purification, chemical modification of immunogens and antibodies, and characterization of antibodies and a range of related services. It also manufactures a line of human-serum-based calibrators for serum protein markers. The company's antibody products and services sells its products to pharmaceutical, biotechnology and diagnostic companies, and biomedical research centers under Strategic BioSolutions brand name. Its food safety product line includes enrichment media and rapid tests to detect food pathogens. The company's water quality products include analytical tests for drinking water, industrial process water and wastewater analysis, and analytical tests for soil and other waste matrices for use at environmental remediation projects, hazardous waste operations, and other applications. Strategic Diagnostics markets and sells its products in the food safety, water quality, and life science antibody markets through direct sales force, Internet, and distributors in Canada, Mexico, Latin America, Europe, and Asia. The company was founded in 1987 and is headquartered in Newark, Delaware.
SIERRA HEALTH SERVICES INC (SIE)
Sierra Health Services, Inc., a managed health care organization, engages in the provision and administration of health care programs in the United States. The company provides managed health care services through a federally qualified health maintenance organization; managed indemnity plans; ancillary products and services that complement its managed health care product lines; and a third-party administrative services program for employer-funded health benefit plans and self-insured workers' compensation plans. It serves employers, government, and individuals. The company is headquartered in Las Vegas, Nevada.
SOMANETICS CORPORATION (SMTS)
Somanetics Corporation engages in the development, manufacture, and marketing of medical devices primarily in the United States. Its INVOS Cerebral Oximeter, a noninvasive patient monitoring system, provides continuous information about changes in the blood oxygen level in the brain. This system is used as monitoring system in hospital care areas, including operating rooms, recovery rooms, ICUs, and emergency rooms. Somanetics also develops and markets the CorRestore system for use in cardiac repair and reconstruction, including heart surgeries called surgical ventricular restoration. The company offers the Cerebral Oximeter to cardiac, cardiovascular and vascular surgeons, neurosurgeons, anesthesiologists, and perfusionists. It sells its devices through direct sales force and independent sales representative firms in the United States, as well as through independent distributors in international markets. Internationally, the company distributes Cerebral Oximeter in 56 countries, including Europe, Canada, and Japan. Somanetics was founded in 1982 and is based in Troy, Michigan.
SONIC INNOVATIONS INC (SNCI)
Sonic Innovations, Inc., engages in the design, development, manufacture, and marketing of digital hearing aids worldwide. It also offers auditory testing equipment that automates commonly performed hearing tests. The company provides various digital hearing aid products, including Natura 3, Natura 2SE, Altair, Tribute, and Quartet in a range of models, such as behind-the-ear, in-the-ear, half-shell, in-the-canal, minicanal, and completely-in-the-canal. Sonic Innovations provides its products primarily to hearing care professionals and hearing impaired consumers. It sells products directly in North America; and through distributors in Germany, Denmark, the Netherlands, Austria, and England, as well as through retail clinics in Australia and Switzerland. The company is based in Salt Lake City, Utah.
SMITH & NEPHEW SNATS INC (SNN)
Smith & Nephew plc engages in the development, manufacture, and marketing of medical devices worldwide. It operates in three segments: Orthopedics, Endoscopy, and Advanced Wound Management. The Orthopedic segments comprises reconstructive joint implants that include hip, knee, and shoulder joints, as well as ancillary products, such as bone cement and mixing systems used in cemented reconstructive joint surgery; trauma products that consists of internal and external fixation devices used in the stabilization of severe fractures; and associated clinical therapies, such as bone growth stimulators and a joint fluid therapy product applied in orthopedic office or clinic setting. It also operates mobile training centers that offer training to surgeons in the U.S. The Endoscopy segment develops and commercializes a range of endoscopic techniques, including fluid management and insufflation equipment for surgical access; digital cameras, digital image capture, central control, multimedia broadcasting, scopes, light sources, and monitors to assist with visualization; radiofrequency wands, electromechanical and mechanical blades, and hand instruments for resecting tissue; and specialized devices, fixation systems, and bioabsorbable materials to repair damaged tissue. It also offers educational programs for surgeons to treat and repair soft tissues, articulating joints, spinal discs, and vascular structures. The Advanced Wound Management segment supplies a range of products and clinical support services for the treatment of chronic and acute skin wounds. Smith & Nephew offers its products primarily to doctors, hospitals, and other healthcare facilities in the United States, Canada, the United Kingdom, Germany, Japan, Australia, France, Italy, New Zealand, and Ireland. The company was founded in 1856 and is headquartered in London.
SonoSite, Inc. engages in the development, manufacture, and sale of hand-carried ultrasound imaging systems for use in clinical applications and settings. Its products are used for imaging in a variety of medical specialties, such as radiology, obstetrics and gynecology, emergency medicine, surgery, cardiology, internal medicine, and vascular medicine. The company's products include SonoSite 180PLUS system for general ultrasound imaging, SonoHeart ELITE for cardiovascular applications, and the SonoSite TITAN system for general imaging and cardiology applications. Its products also include the iLook 25, an imaging tool designed to provide visual guidance for physicians and nurses while performing vascular access procedures, as well as iLook 15, also an imaging tool designed to provide visual imaging of the chest and abdomen for physicians and nurses while performing other procedures and examinations. In addition, the company offers a selection of accessories, including mobile docking stations, multiple transducer connections, image transfer and management software, printers, VCRs, auxiliary monitors, storage devices, carrying cases, and disposable supplies for its products. SonoSite, Inc. sells its products through direct sales representatives and their managers, independent third-party distributors, and strategic alliances in the United States, the United Kingdom, Germany, France, Spain, Japan, Australia, and Canada. SonoSite was incorporated in 1986 and is headquartered in Bothell, Washington.
SPAN-AMERICA MEDICAL SYSTEMS INC (SPAN)
Span-America Medical Systems, Inc. engages in manufacturing and distributing various polyurethane foam products for the medical and custom products markets in the United States. Its medical products consist of therapeutic support surfaces, including polyurethane foam mattress overlays, nonpowered replacement mattresses, and powered replacement mattresses; patient positioners; and seating products. The company's custom products include two product lines, consumer products and industrial products. The consumer product line consists of convoluted and geo-mattress overlays, and pillows for the consumer bedding market. These products are marketed to retailers in North America. The industrial product line includes foam packaging and cushioning materials. The company also produces foam products for flotation, sound insulation, and gasketing purposes. Its wound care products serve in the treatment or prevention of pressure ulcers known as bed sores or diabetic ulcers. The company markets its products through sales representatives and manufacturers' representatives to sports equipment, automotive, photographic film, durable goods, and electronics industries, primarily in the southeastern United States. Span-America Medical Systems was founded by Don Spann. The company was incorporated in 1970. Span-America Medical Systems is headquartered in Greenville, South Carolina.
SPECTRANETICS CORPORATION (SPNC)
The Spectranetics Corporation, a medical device company, engages in the development, manufacture, and marketing of single-use medical devices used in minimally invasive surgical procedures within the cardiovascular system in conjunction with its proprietary excimer laser system. Its excimer laser system includes the CVX-300 laser unit; and various fiber-optic delivery devices, including disposable catheters and sheaths. This system is approved in the United States and Europe for use in multiple, minimally invasive cardiovascular applications. The excimer laser system is used in complex atherectomy procedures to open clogged or obstructed arteries in the coronary vascular system. It is also used to remove lead wires from patients with implanted pacemakers or cardioverter defibrillators, which are electronic devices that regulate the heartbeat. The company sells its products to customers in Canada, Mexico, South America, the Pacific Rim, Australia, Europe, and the Middle East. Spectranetics was founded by Robert Golobic and Johan Sverdrup in 1984. The company is headquartered in Colorado Springs, Colorado.
STAAR SURGICAL COMPANY (STAA)
STAAR Surgical Company engages in the development, manufacture, and distribution of medical devices for use in cataract, refractive, and glaucoma surgeries. The company's cataract surgery products include foldable silicone and Collamer intraocular lenses (IOLs) used after minimally invasive small incision cataract extraction; the Preloaded Injector, a three-piece silicone IOL preloaded into a single-use disposable injector; STAARVISC II, a viscoelastic material; the STAAR SonicWAVE Phacoemulsification System; Cruise Control, a disposable filter that allows for phacoemulsification procedure; and Silicone Toric IOLs, used in cataract surgery to treat astigmatic vision abnormalities. STAAR Surgical offers VISIAN ICL and VISIAN TICL to treat refractive disorders, such as myopia, hyperopia, and astigmatism in the area of refractive surgery. The company's AquaFlow Collagen Glaucoma Drainage device is an alternative method of treating open angle glaucoma. STAAR Surgical also sells other instruments, devices, and equipment that it manufactures or that are manufactured by others in the ophthalmic industry. It markets its products through direct sales force, distributors, and a network of independent manufacturers' representatives to various health care providers, including surgical centers, hospitals, managed care providers, health maintenance organizations, group purchasing organizations, and government facilities. The company was founded in 1982 and is headquartered in Monrovia, California.
STERIS Corporation engages in the development, manufacture, and marketing of infection prevention, contamination control, microbial reduction, and surgical and critical care support products and services for healthcare, scientific, research, industrial, and government customers worldwide. It operates through three segments: Healthcare, Life Sciences, and STERIS Isomedix Services. The Healthcare segment offers capital equipment, including general and specialty surgical tables, surgical and examination lights, equipment management systems, operating room storage cabinets, warming cabinets, scrub sinks, and other products and accessories; technologies for sterilizing medical devices and instruments; automated washer/disinfector systems; infection prevention consumables and supplies; and skin care and hand hygiene solutions for use in surgical environments, critical care environments, emergency departments, gastrointestinal environments, sterile processing environments, and in infection control processes. The Life Sciences segment provides capital equipment and accessories, washers, sterilizers, infection prevention consumables and supplies, and skin care and hand hygiene solutions for pharmaceutical and research, defense and aerospace, and industrial decontamination markets. The Isomedix Services segment offers contract sterilization, microbial reduction, and materials modification services to companies that supply products to the healthcare, industrial, and consumer product industries. The company sells products through its sales force and distributors. STERIS Corporation was founded in 1985 and is headquartered in Mentor, Ohio.
ST. JUDE MEDICAL INC (STJ)
St. Jude Medical, Inc. engages in the development, manufacture, and distribution of cardiovascular medical devices for the cardiac rhythm management (CRM), cardiac surgery (CS), and cardiology and vascular access (C/VA) therapy areas worldwide. It offers a range of CRM products, such as bradycardia pacemaker systems, tachycardia implantable cardioverter defibrillator systems, and electrophysiology catheters; various CS products, including mechanical and tissue heart valves, valve repair products, and epicardial ablation systems; and C/VA products, that include vascular closure devices, angiography catheters, guidewires, and hemostasis introducers. The company markets and sells its products through direct sales force and independent distributors in the United States, Europe, and Japan, as well as in Canada, Latin America, Australia, New Zealand, and the Asia-Pacific region. St. Jude Medical was founded in 1976 and is headquartered in St. Paul, Minnesota.
STRYKER CORPORATION (SYK)
Stryker Corporation engages in the development, manufacture, and marketing of orthopedic products and medical specialties worldwide. It operates in two segments, Orthopedic Implants and MedSurg Equipment. The Orthopedic Implants segment sells orthopedic reconstructive, trauma, spine and micro implant systems, bone cement, and the bone growth factor OP-1 products. The MedSurg Equipment segment offers powered surgical instruments, surgical navigation systems, endoscope products, medical video imaging equipment, and hospital beds and stretchers. The company also provides outpatient physical therapy services to its customers that includes physical, occupational, and speech therapy services to patients recovering from orthopedic or neurological illness and injury. Its products are sold in approximately 100 countries through local dealers and direct sales efforts. The company was founded in 1941 and is headquartered in Kalamazoo, Michigan.
TENET HEALTHCARE CORPORATION (THC)
Tenet Healthcare Corporation operates as a health care services company in the United States. The company, through its subsidiaries, provides healthcare services primarily through the operation of general hospitals and related health care facilities. Its hospitals offer acute care services, operating and recovery rooms, radiology services, respiratory therapy services, clinical laboratories, and pharmacies; intensive care, critical care, and/or coronary care units; physical therapy; and orthopedic, oncology, and outpatient services. The hospitals also offer tertiary care services, such as open-heart surgery, neonatal intensive care, and neuroscience; quaternary care services in areas, such as heart, lung, liver, and kidney transplants; and bone marrow transplants. As of December 31, 2004, it operated 80 general hospitals, with 19,668 licensed beds, serving urban and rural communities in 13 states. Of 80 general hospitals, 64 were owned by its subsidiaries, and 16 were owned by third parties and leased by its subsidiaries. The company also owned or leased various related health care facilities, including 2 rehabilitation hospitals, 1 specialty hospital, 4 nursing facilities, and 85 medical office buildings; and owned or leased physician practices, captive insurance companies, and various ancillary health care businesses, including outpatient surgery centers, occupational and rural health care clinics, and an interest in a health maintenance organization, as of the above date. Tenet Healthcare Corporation is headquartered in Dallas, Texas.
THORATEC CORPORATION (THOR)
Thoratec Corporation manufactures circulatory support products for use by patients with congestive heart failure. The company operates in two segments, Cardiovascular and International Technidyne Corporation (ITC). The Cardiovascular segment develops, manufactures, and markets medical devices used for circulatory support products, which include ventricular assist device for the short-term and long-term treatment of congestive heart failure, as well as vascular graft products for use as a shunt between an artery and a vein. It offers a product portfolio of implantable and external circulatory support product devices, including the Thoratec Implantable Ventricular Assist Device, a biventricular implantable blood pump; the HeartMate Left Ventricular Assist System (LVAS), an implantable device for mid to long-term cardiac support for those patients ineligible for heart transplantation; and the HeartMate II, an implantable LVAS consisting of a miniature rotary blood pump that is designed to provide long-term support. These products are sold into the hospital point-of-care (POC) market, and the alternate site POC market comprising physician's offices, long-term care facilities, clinics, visiting nurse associations, and home healthcare companies. ITC segment designs, develops, manufactures, and markets point-of-care diagnostic test systems that monitor a patient while being administered certain anticoagulants, blood gas/electrolyte, and chemistry status or anemia; and incision products to obtain a patient's blood sample for diagnostic testing and screening for platelet function. The company markets its products through direct sales force and distributors in the United States, Canada, France, Germany, Spain, the United Kingdom, Austria, Switzerland, the Netherlands, Portugal, and South Africa. Thoratec Corporation was founded in 1976 and is headquartered in Pleasanton, California.
TLC VISION CORPORATION (TLCV)
TLC Vision Corporation, an eye care services company, provides eye doctors in North America and Europe with tools and technologies needed to deliver patient care. The company, through its centers management and technology access service models, and its managed care contracting strength, operates in the Refractive, Cataract, and Age-Related Macular Degeneration (AMD) segments. The Refractive segment comprises laser centers, and the fixed and mobile access business. It provides corrective laser surgery primarily relating to refractive disorders, such as myopia, hyperopia, and astigmatism. The Cataract segment furnishes hospitals and independent surgeons with mobile or fixed site access to cataract surgery equipment and services. It provides surgery for the treatment of cataracts. The AMD segment focuses on the treatment of a specific eye disease, known as dry age-related macular degeneration, via rheopheresis, which is a process for filtering blood. It also develops, manages, and has equity participation in single-specialty eye care ambulatory surgery centers and multispecialty ambulatory surgery centers. In addition, the company provides franchise opportunities to independent optometrists; and manages cataract and secondary care centers that provide advanced levels of eye care, network marketing and management, and professional healthcare facility management. It owns and manages 73 laser eye centers in the United States, 5 centers in Canada, and 1 in Europe. The company was incorporated in 1993. It was formerly known as TLC The Laser Center, Inc. and changed its name to TLC Laser Eye Centers, Inc. in 1999, and then to TLC Vision Corporation in 2002. TLC Vision Corporation is headquartered in Mississauga, Canada.
TRANSCEND SERVICES INC (TRCR)
Transcend Services, Inc. provides medical transcription services to healthcare industry. Its services include receiving, typing or editing, formatting, and distributing electronic copies of physician-dictated medical documents. It converts physicians' voice recordings into electronic medical record documents using Web-based voice and data distribution technology to provide patient care. The company also offers network/data center services, including design, building, and managing of data centers designed to support transcription services. It serves hospitals, hospital systems, multispecialty clinics, and physician group practices in the United States. Transcend was founded in 1976 and is headquartered in Atlanta, Georgia.
Trimeris, Inc. engages in the identification, development, and commercialization of therapeutic agents that block viral infection by inhibiting viral fusion with host cells. Its principal drug candidate, Fuzeon, is a human immunodeficiency virus (HIV) fusion inhibitor approved in the United States, Canada, European Union, and other countries for the treatment of HIV-1 infection in treatment-experienced patients with evidence of HIV-1 replication despite ongoing antiretroviral therapy. The company has a collaboration agreement with F. Hoffmann-La Roche, Ltd. to develop and market Fuzeon and T-1249, a replacement compound. Trimeris was founded by Dani Bolognesi and Tom Matthews in 1993 and is based in Morrisville, North Carolina.
TUTOGEN MEDICAL INC (TTG)
Tutogen Medical, Inc., together with its subsidiaries, engages in processing, manufacturing, and distributing specialty surgical products made from human (allograft) and animal (xenograft) tissue. It processes human donor tissue utilizing its patented tissue preservation and sterilization process Tutoplast'. The company contracts with independent tissue banks and procurement organizations to provide donated human tissue for processing under the company's proprietary Tutoplast process. Its Tutoplast process utilizes solvent dehydration and chemical inactivation, which is applied to two types of preserved allografts: soft tissue, which consists of fascia lata, fascia temporalis, pericardium, dermis, sclera, ligaments, tendons and cartilage; and bone tissue that includes various configurations of cancellous and cortical bone material. Processed pericardium, fascia lata, and dermis are collagenous tissue used to repair, replace, or line native connective tissue primarily in neurosurgery, ophthalmology, urology procedures, and plastic and reconstructive surgeries; dermis is used in pelvic floor reconstruction; sclera is used in ophthalmology procedures such as, anterior and posterior segment patch grafting applications for glaucoma, retina, and trauma surgery and oculoplastics, as well as contour wrapping of an orbital implant; and ligaments, tendons, and cartilage are used primarily in orthopedic and trauma repairs. Processed cortical and cancellous bone material is used in various applications in spinal and dental surgeries. Tutogen Medical also performs tissue processing services for neuro, orthopedic, reconstructive and general surgical applications. It primarily serves hospitals and surgeons through marketing and distribution partners, direct representatives, and distributors worldwide. The company was founded in 1984 and is headquartered in West Paterson, New Jersey.
UNIVERSAL HEALTH SERVICES INC (UHS)
Universal Health Services, Inc., through its subsidiaries, engages in the ownership and operation of acute care hospitals, behavioral health centers, and ambulatory surgery and radiation oncology centers. Its hospitals provide general surgery, internal medicine, obstetrics, emergency room care, radiology, oncology, diagnostic care, coronary care, pediatric services, and behavioral health services. As of March 1, 2005, it operated 44 acute care hospitals and 49 behavioral health centers located in the United States, Puerto Rico, and France. The company was founded by Alan B. Miller in 1978. Universal Health Services is based in King of Prussia, Pennsylvania.
Urologix, Inc. engages in the design, development, manufacture, and marketing of medical devices for the treatment of benign prostatic hyperplasia (BPH). It markets its products under Targis and Prostatron names. BPH is a disease that causes adverse changes in urinary voiding patterns in men. The company offers nonsurgical and catheter-based therapies that use a proprietary cooled microwave technology. Urologix is based in Minneapolis, Minnesota.
UNITEDHEALTH GROUP INCORPORATED (UNH)
UnitedHealth Group Incorporated provides health care services in the United States. It operates in four segments: Uniprise, Health Care Services, Specialized Care Services, and Ingenix. Uniprise segment provides a range of employer business services to meet the needs of national employers and health plans. Health Care Services segment offers network-based health care services through its AmeriChoice, Ovations, and UnitedHealthcare businesses. Specialized Care Services segment offers health and wellness benefits, services, and resources. It provides chiropractic care, physical therapy, complementary medicine, and health and wellness services; integrated personal health management solutions, including consumer health information, education, and decision support services; and life, disability, dental, stop-loss, and critical illness insurance for employers and their employees. Ingenix segment provides a range of data and software analytics, warehousing, and technology services and products that help the customers in delivering health care services. The company's customers include pharmaceutical, biotechnology, and medical device companies; health insurers and other payers; physicians and other health care providers; large employers; and government agencies. As of December 31, 2004, the company provided health care services and resources to individuals through approximately 460,000 physicians and 4,200 hospitals. UnitedHealth Group was founded in 1974 under the name United HealthCare Corporation and changed its name to UnitedHealth Group Incorporated in 1998. UnitedHealth Group is based in Minnetonka, Minnesota.
U.S. PHYSICAL THERAPY INC (USPH)
U.S. Physical Therapy, Inc., through its subsidiaries, engages in the development, ownership, and operation of outpatient physical and occupational therapy clinics. Its clinics provide pre and postoperative treatment for orthopedic-related disorders, sports-related injuries, preventative care, rehabilitation of injured workers, and neurological-related injuries. As of December 31, 2004, the company operated 264 outpatient physical and occupational therapy clinics in 35 states in the United States. In addition, the company also managed physical therapy facilities for third parties, including hospitals and physician groups. It focuses its marketing efforts primarily on physicians, including orthopedic surgeons, neurosurgeons, physiatrists, occupational medicine physicians, and general practitioners. U.S. Physical Therapy, Inc. was founded in 1990 and is based in Houston, Texas.
UTAH MEDICAL PRODUCTS INC (UTMD)
Utah Medical Products, Inc. (UMP) engages in the development, manufacture, assembling, and marketing of disposable and reusable specialty medical devices. It offers medical devices used in critical care areas, especially the neonatal intensive care unit, and the labor and delivery department in hospitals, as well as products sold to outpatient clinics and physician's offices. The company's obstetrics products include fetal monitoring accessories, vacuum-assisted delivery systems, and other obstetrical tools. Its neonatal intensive care products include the DISPOSA-HOOD, an infant respiratory hood; DELTRAN PLUS, a blood pressure monitoring system; and umbilical vessel catheters. The company's other specialty products include a disposable peritoneal dialysis set, a silicone oral protection device used to prevent palatal soft tissue injury by orotracheal tubes, and a lumbar sampling kit for obtaining cerebral spinal fluid samples. UMP's gynecology/urology/and electro surgery products consists of the LETZ System that is used to excise cervical intraepithelial neoplasia and other lower genital tract lesions related to human papilloma virus infections; FINESSE electrosurgical system and specialized electrodes; EPITOME, an electrosurgical scalpel; LIBERTY System to treat urinary incontinence in women; PATHFINDER PLUS, an endoscopic irrigation device; ENDOCURETTE for uterine endometrial tissue sampling; and LUMIN for manipulation of the uterus in gynecological laparoscopic procedures. Its blood pressure monitoring line comprises DELTRAN disposable pressure transducer; and pressure monitoring accessories, components, and other molded parts. The company sells its products through direct sales representatives and independent manufacturers' representatives in the United States, as well as through specialty distributors, other medical device companies, and independent medical products distributors internationally. UMP was formed in 1978 and is headquartered in Midvale, Utah.
VARIAN MEDICAL SYSTEMS INC (VAR)
Varian Medical Systems, Inc. engages in the design, manufacture, sale, and service of equipment and software products to treat cancer with radiation. The company operates in two segments, Oncology Systems and X-ray Products. The Oncology Systems segment designs, manufactures, sells, and services hardware and software products for treating cancer with radiation, including linear accelerators, treatment simulation and verification products, information management and treatment planning software, and other accessory products and services. This segment's customers include comprehensive cancer treatment clinics, university research and community hospitals, private and governmental institutions, healthcare agencies, doctors' offices, and cancer care clinics worldwide. The X-ray Products segment manufactures and sells X-ray imaging components and subsystems, such as X-ray tubes for use in computed tomography, scanning, radioscopic/fluoroscopic imaging, mammography, special procedures, and industrial applications; and flat panel imaging products for digital X-ray image capture. This segment's products are sold to original equipment manufacturers and end-users. The company markets its products through independent distributors in North America, Europe, Australia, Asia, and Latin America. Varian Medical Systems was incorporated as Varian Associates, Inc. in 1948 and is based in Palo Alto, California.
VASCULAR SOLUTIONS INC (VASC)
Vascular Solutions, Inc., a medical device company, develops solutions to interventional cardiologists and radiologists. Its products include D-Stat Dry hemostatic bandage, a topical pad with a bandage used to control surface bleeding; Pronto extraction catheter, a mechanical system for the removal of soft thrombus from arteries; Vari-Lase endovenous laser, a laser and procedure kit used for the treatment of varicose veins; and Duett sealing device, which is used to seal the puncture site following catheterization procedures. The company also offers D-Stat Flowable hemostat, a mixture used to control bleeding; Langston dual lumen pigtail catheter that is used to measure intravascular pressure gradients; MAX-Support abdominal retraction belt, which is used to allow femoral access in obese patients, and Acolysis ultrasound, a treatment for peripheral occlusive arterial disease. Vascular Solutions offers its products to the physician in the United States and internationally through its direct domestic sales force and international distribution network. The company was founded by Howard Root. Vascular Solutions was incorporated in 1996 and is based in Minneapolis, Minnesota.
Orthovita, Inc. engages in the development and marketing of synthetic-based biomaterial products for use in spine surgery, the repair of osteoporotic fractures, and a range of clinical needs in the trauma, joint reconstruction, revision, and extremities markets primarily in the United States. Its products include VITOSS bone graft substitute (VITOSS), IMBIBE bone marrow aspirate syringe (IMBIBE), ENDOSKELETON TA device, CORTOSS synthetic cortical bone void filler (CORTOSS), VITAGEL surgical hemostat, and ALIQUOT microdelivery system. VITOSS is an ultra-porous resorbable beta-tricalcium phosphate bone void filler used to enable the body guide the three-dimensional regeneration of the patient's own bone. The IMBIBE provides spine and orthopedic surgeons with a method for harvesting a patient's bone marrow, mixing it with VITOSS and delivering the mixture to the bone graft site. ENDOSKELETON TA device provides physiological support to, or replaces damaged vertebral bodies. The CORTOSS is a bone-bonding and self-setting composite engineered specifically to mimic the characteristics of human cortical bone. VITAGEL is a composite liquid hemostat that combines the biomaterials thrombin and collagen with the patient's autologous plasma for soft-tissue healing. The ALIQUOT microdelivery system facilitates delivery of the company's CORTOSS product directly to the surgical site. Orthovita also offers VITOMATRIX particulate synthetic scaffold biomaterial and bone graft substitute materials, such as VITOSS FOAM products, which combine VITOSS technology with resorbable biomaterials to produce an array of pliant, flexible, flowable, and compression resistant bone graft materials. In addition, the company distributes products, which compliment its biomaterial platforms. It sells its products through direct sales force, independent sales agency, and stocking distributors. Orthovita was incorporated in 1992 and is headquartered in Malvern, Pennsylvania.
Vital Signs, Inc. engages in the design, manufacture, and marketing of medical products for the anesthesia, respiratory, critical care, neonatal, sleep therapy, and emergency markets. It operates in four segments: Anesthesia, Respiratory/Critical Care, Sleep Disorder, and Pharmaceutical Technology Services. Anesthesia segment offers single-patient use anesthesia breathing circuits; face masks; general anesthesia systems. These products comprise air-filled cushion face masks, breathing circuits, and temperature monitoring probes; single limb breathing circuits; single use airway devices; and fiberoptic laryngoscope systems. This segment also manufactures and sells introducers, sheaths, dilators, hemostasis valves, and catheters. Respiratory/Critical Care segment provides disposable arterial blood gas syringes and collection systems, manual resuscitators, hyperinflation systems, blood pressure cuffs, face masks, respiratory product lines that deliver hydration to a patient, cardiopulmonary resuscitation training manikins, and pediatric emergency system. Sleep Disorder segment offers sleep disorder/personal ventilation products that include continuous positive airway pressure flow generators, humidification systems, sleep disorder home screening devices, life support ventilator, and other ventilators. This segment also provides diagnostic and therapeutic services for sleep disorders. Pharmaceutical Technology Services segment offers consulting services to medical device, diagnostic, and biotechnology companies, which help them to develop and validate systems and processes for their manufacturing, infrastructure, research and development, and laboratory and quality assurance departments. The company serves various hospitals, surgery centers, and health care providers primarily in the United States, Europe, and Asia. Vital Signs was founded by Terry D. Wall in 1972 and is headquartered in Totowa, New Jersey.
VENTANA MEDICAL SYSTEMS INC (VMSI)
Ventana Medical Systems, Inc. engages in the development, manufacture, and marketing of instrument-reagent systems that automate slide staining in anatomical pathology and drug discovery laboratories worldwide. Its clinical systems are used in anatomical pathology labs in analyzing human tissue to assist in the diagnosis and treatment of cancer and infectious diseases. The company's drug discovery systems are used by pharmaceutical and biotechnology companies to accelerate the discovery of new drug targets and to evaluate the safety of new drug compounds. In addition, Ventana Medical Systems markets consumable products, including reagents and other accessories, required to operate its instruments. Its products are used in immunohistochemistry staining to assist in the diagnosis of cancer and the determination of various treatment options; in situ hybridization staining to assist in the diagnosis of infectious diseases or genetic mutations that are associated with the presence of cancer; and special stains staining to assist in the diagnosis of infectious diseases. The company's customers comprise hospital-based anatomical pathology labs, independent reference labs, the drug discovery labs of pharmaceutical companies, biotechnology companies, government labs, medical research centers, and resellers serving these entities. It offers products primarily in North America, Europe, Japan, and Asia Pacific. Ventana Medical was founded by Thomas M. Grogan in 1985 and is headquartered in Tucson, Arizona.
VISION-SCIENCES INC (VSCI)
Vision-Sciences, Inc. engages in the design, development, manufacture, and marketing of endoscope products for the medical device and industrial device markets. It operates in two segments, Medical and Industrial. The Medical segment supplies flexible endoscopes and disposable Slide-On EndoSheath systems to the ear-nose-throat (ENT), gastrointestinal, urology, and pulmonary markets. EndoSheaths are primarily used by health-care providers to cover the insertion tube of flexible endoscopes, such as ENT endoscopes, Trans-Nasal Esophagoscopes, sigmoidoscopes, cystoscopes, and bronchoscopes. The Industrial segment manufactures and repairs flexible endoscopes, such as nasopharyngolaryngo endoscopes, the ENT-2000, and ENT-1000 for the ENT market; and trans-nasal diagnostic esophagoscope, trans-nasal therapeutic esophagoscope, cystoscope, sigmoidoscope, and bronchoscope. It also designs, manufactures, and markets flexible endoscopes for industrial markets, primarily aircraft maintenance, jet engine manufacturing, and defense. Vision-Sciences offers its disposable EndoSheaths, flexible endoscopes, and related products primarily to otolaryngologists, urologists, gastroenterologists, pulmonologists, and primary care physicians in hospitals, medical clinics, and physicians' offices in the united States and internationally. The company was incorporated as Machida Incorporated in 1987 and changed its name to Vision-Sciences, Inc. in 1990. Vision-Sciences is based in Natick, Massachusetts.
Vital Images, Inc. provides visualization and analysis solutions for use in clinical diagnosis, disease screening applications, and therapy planning. The company's primary software products include Vitrea and ViTALConnect. Vitrea is a visualization product for radiological and surgical applications. It allows clinicians to screen for disease, diagnose less invasively, and plan treatments. Vitrea offers various optional modules to enable clinicians to customize their Vitrea workstations for their specialties. Its modules include 3D Angio, Automated Vessel Measurements, CT Brain Perfusion, CT Cardiac, CT Colon, Fusion7D, ImageChecker CT, Lung, SoftRead, Vessel Probe, and VScore. Vitrea 2 is offered both as a stand-alone software package and as part of an integrated software and hardware system, consisting of Vitrea 2 software installed on a computer workstation. ViTALConnect enables physicians and other users to access 2D, 3D, and 4D enterprise-wide visualization capabilities, including the ability to measure, rotate, analyze, and segment images, with a personal computer using a Web-enabled browser. Its users can employ a PC or notebook computer to process, analyze, review, and distribute multidimensional medical images securely over the Web. In addition, a collaboration mode lets several physicians in different locations confer while interacting with the same images in real time. It markets Vitrea 2 and ViTALConnect as standalone software packages and as part of integrated software and hardware systems to radiologists, surgeons, primary care physicians, and medical researchers. The company sells its products to end-user customers, such as hospitals and clinics, and to diagnostic imaging companies, digital imaging equipment manufacturers, and picture archive and communication systems companies. The company was founded by Vincent Argiro in 1988. Vital Images is headquartered in Minneapolis, Minnesota.
VIVUS, Inc., a pharmaceutical company, engages in the research, development, and commercialization of products to restore sexual function in women and men. Its product pipeline includes four clinical stage product candidates, including ALISTA for the treatment of female sexual arousal disorder; Testosterone-MDTS to treat hypoactive sexual desire disorder; Evamist to alleviate symptoms associated with menopause; and Avanafil, an inhibitor product candidate for the treatment of erectile dysfunction. ALISTA and Evamist are in Phase 3 trials; and Testosterone-MDTS and Avanafil are in Phase 2 trials. The company also markets MUSE, a transurethral applicator used for treating erectile dysfunction, in the United States and internationally through distribution partners. It has a development, license, and supply agreement with Tanabe Seiyaku Co., Ltd., for the development and commercialization of avanafil; and licensing agreements with Acrux Limited to develop and commercialize testosterone-MDTS and Evamist in the United States for various female health applications. VIVUS was founded by Virgil A. Place in 1991 and is headquartered in Mountain View, California.
WORLD HEART CORPORATION (WHRT)
World Heart Corporation (WHC), a global medical device company, engages in the development, production, and commercialization of implantable ventricular assist devices (VADs). VADs are mechanical pumps that enable the restoration of normal blood circulation of patients suffering from late-stage congestive heart failure. The company manufactures and sells Novacor left ventricular assist system (LVAS) and related peripheral equipment. Novacor LVAS is an electromagnetically-driven pump that provides circulatory support for patients with heart failure by taking over the workload of the left ventricles of the heart. The Novacor LVAS is approved as a bridge to transplantation device in the United States and Canada. In Europe, the Novacor LVAS has unrestricted approval for use as an alternative to transplantation, a bridge to transplantation, and to support patients who might have an ability to recover the use of their natural heart. In Japan, the device is approved for use in cardiac patients at risk of imminent death from nonreversible left ventricular failure. The company sells Novacor LVAS directly to medical clinics and hospitals in the United States, Europe, and Canada, as well as through a distributor in Japan and various other countries. In addition, WHC is developing a small implantable pulsatile VAD, Novacor II, which has completed animal implant; and MedQuest rotary VAD, a nonpulsatile VAD that is in preclinical animal and bench testing. The company has facilities in Oakland, California; Salt Lake City, Utah; and Heesch, the Netherlands. WHC was established in 1996 and is headquartered in Oakland, California. World Heart Corporation acquired MedQuest Products, Inc., a medical device company, in August 2005.
WELLPOINT HEALTH NETWORKS INC (WLP)
WellPoint, Inc., through its subsidiaries, operates as a commercial health benefits company in the United States. It offers a spectrum of network-based managed care plans to the large and small employer, individual, Medicaid, and senior markets. The company's managed care plans include preferred provider organizations, health maintenance organizations, point-of-service plans, other hybrid plans, and traditional indemnity plans. In addition, WellPoint provides an array of managed care services, including claims processing, underwriting, stop loss insurance, actuarial services, provider network access, medical cost management, and other administrative services to self-funded customers. It also offers an array of specialty and other products and services, including pharmacy benefit management; group life and disability insurance benefits; dental, vision, and behavioral health benefits; workers compensation; and long term care insurance. The company operates as an independent licensee of the Blue Cross and Blue Shield Association; and serves its members as the Blue Cross licensee for California; the Blue Cross and Blue Shield licensee for Colorado, Connecticut, Georgia, Indiana, Kentucky, Maine, Missouri, Nevada, New Hampshire, Ohio, Virginia, and Wisconsin; and through HealthLink and UniCare. WellPoint is based in Indianapolis, Indiana.
DENTSPLY INTERNATIONAL INC (XRAY)
DENTSPLY International, Inc. and its subsidiaries engage in the design, development, manufacture, and marketing of a range of professional dental products worldwide. The company's principal dental products include dental consumables, including dental anesthetics, prophylaxis paste, dental sealants, impression materials, restorative materials, tooth whiteners, and topical fluoride; dental laboratory products which include dental prosthetics, such as artificial teeth, precious metal dental alloys, dental ceramics, and crown and bridge materials; and dental specialty products, including endodontic instruments and materials, implants, and orthodontic appliances and accessories. DENTSPLY International distributes its products through domestic and foreign distributors, dealers, and importers, as well as directly to the dental laboratory or dental professionals. DENTSPLY International is headquartered in York, Pennsylvania.
YOUNG INNOVATIONS INC (YDNT)
Young Innovations, Inc. engages in the development, manufacture, and marketing of supplies and equipment used to enable the practice of dentistry and to promote oral health. Its products include disposable and metal prophylaxis angles, prophylaxis cups and brushes, X-ray machines, moisture control products, infection control products, dental handpieces (drills) and related components, endodontic systems, orthodontic toothbrushes, flavored examination gloves, children's toothbrushes, and children's toothpastes, as well as ultrasonic systems and obturation products used in endodontic surgeries, such as root canal procedures. The company markets its products to dentists, endodontists, orthodontists, dental hygienists, and dental assistants primarily through a network of nonexclusive relationships with dental product distributors. In addition, Young Innovations sells directly to dental and dental hygiene schools, Veterans Administration healthcare facilities, and the U.S. military bases. It offers its products in North America, Europe, South America, Central America, and the Pacific Rim. The company was incorporated in 1995. It was formerly known as Young Dental and changed its name to Young Innovations, Inc. in 1995. Young Innovations is headquartered in Earth City, Missouri.
ZOLL MEDICAL CORPORATION (ZOLL)
ZOLL Medical Corporation engages in designing, manufacturing, and marketing noninvasive resuscitation devices and related software solutions in the United States and internationally. The company also offers software that automates the documentation and management of both clinical and nonclinical information. ZOLL's cardiac resuscitation products include M Series defibrillators, which offers data management, diagnostic 12-lead ECG with interpretive statement, GEMS muse cardiology information system, Pulse oximetry, capnography, and noninvasive blood pressure measurement for both hospital and prehospital markets; critical care transport defibrillators; AED plus automated external defibrillators; biphasic waveforms; and disposable electrodes, such as pro-padz biphasic multifunction electrodes and CPR-D Padz electrode for use with its resuscitation devices. It offers its products for pacing, defibrillation, circulation, ventilation, and fluid resuscitation. The company's products enable healthcare professionals, emergency medical service providers, and first responders to diagnose and treat victims of trauma, as well as sudden cardiac arrest. ZOLL Medical markets its products through sales and managerial staff, as well as through distributors and other indirect channels in the hospital, EMS, and public access market. The company was incorporated in 1980 and is headquartered in Chelmsford, Massachusetts.
ZEVEX INTERNATIONAL INC (ZVXI)
ZEVEX International, Inc. (ZEVEX), together with its subsidiary, engages in the design, manufacture, and distribution of medical devices. The company operates in two divisions segments, Therapeutics and Applied Technology. The Therapeutics segment produces enteral nutrition delivery devices, such as enteral feeding pumps and various related disposable delivery sets used for delivering nutrition to patients through the gastrointestinal tract. The Applied Technology segment provides design and manufacturing services to medical device companies. Its original equipment manufacturer products include ultrasonic sensors for the detection of air bubbles and the monitoring of liquid levels in medical systems; surgical handpieces for the surgical removal of cataracts; optoelectronic components, such as optical emitters and detectors, custom integrated circuit products, and semiconductor components used in medical applications; and electronic instruments. The company was organized in 1987 as Downey Industries, Inc. and changed its name to ZEVEX International, Inc. in 1988. ZEVEX is headquartered in Salt Lake City, Utah.