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SYNOVIS LIFE TECHNOLOGIES INC (SYNO)

Synovis Life Technologies, Inc. operates as a diversified medical device company in the United States. It operates through two segments, Surgical and Interventional. The Surgical segment develops, manufactures, and markets implantable biomaterial products, devices for microsurgery, and surgical tools designed to reduce risk and/or facilitate critical surgeries. This segment also offers Tissue-Guard, which is used to repair and replace damaged tissue in cardiac, vascular, thoracic, abdominal, and neuro surgeries; and Veritas product line for use in pelvic floor reconstruction, stress urinary incontinence treatment, vaginal and rectal prolapse repair, hernia repair, as well as soft tissue repair. Its products are sold by third party distributors and independent sales representatives to surgeons and hospitals under the Synovis brand name. The Interventional segment develops, engineers, prototypes, and manufactures coils, helices, stylets, guidewires, and other micro-wire, polymer, and micro-machined metal components used in interventional devices for cardiac rhythm management, neurostimulation, vascular, and other procedures. These products are sold primarily to other medical device manufacturing companies who incorporate them into their own products. The company was founded in 1985. It was formerly known as Bio-Vascular, Inc. and changed its name to Synovis Life Technologies, Inc. in 2002. Synovis Life Technologies is headquartered in St. Paul, Minnesota.


HANSEN MEDICAL INC (HNSN)

Hansen Medical, Inc. engages in the development and manufacture of medical robotics for positioning, manipulation, and stable control of catheters and catheter-based technologies. It offers Sensei system, which is designed to allow physicians to navigate flexible catheters with stability and control in interventional procedures. This system comprises two portable modules, a physician control console that features a motion controller that robotically controls the patient-side module to move the catheter within the patient anatomy; and patient-side module, a robotic manipulator actuated by motors that control pull-wires in its Artisan control catheters. The company also offers Artisan control catheter and sheath assembly consists of a telescoping set of control catheters that are integrated to provide the desired motion of the tip of a diagnostic or therapeutic catheter; and Elite transseptal system that comprise a needle and dilator assembly designed to puncture and expand the atrial septum of the heart in order to allow access to the left heart chambers. The company was founded as AutoCath, Inc. in 2002 and changed its name to Hansen Medical, Inc. in 2003. Hansen Medical is headquartered in Mountain View, California.


INTUITIVE SURGICAL INC (ISRG)

Intuitive Surgical, Inc. engages in the design, manufacture, and marketing of the da Vinci Surgical System for use in urologic, cardiothoracic, and general surgeries. The da Vinci Surgical System consists of a surgeon's console, a patient-side cart, and proprietary instruments. It translates the surgeon's natural hand movements on instrument controls at a console into corresponding micro-movements of instruments positioned inside the patient through small puncture incisions or ports. The system provides the surgeon with motion, fine tissue control, and 3-D vision characteristic of open surgery, while simultaneously allowing the surgeon to work through small ports. The company also manufactures various EndoWrist instruments, including forceps, scissors, electrocautery, scalpels, and other surgical tools, which incorporate a wrist joint with tips customized for various surgical procedures. Its other products include Aesop Endoscope Positioner, a voice-activated robotic arm that automates the critical task of endoscope positioning; and Hermes Control Center, a centralized system designed to voice control a series of networked smart medical devices. The company sells its products through direct sales force in the United States and Europe, as well as through distributors in Australia, Canada, India, Italy, Romania, Saudi Arabia, Singapore, Taiwan, and Turkey. Intuitive surgical was co-founded by John G. Freund, Frederic Moll, and Robert Younge in 1995. The company is headquartered in Sunnyvale, California.


CYNOSURE INC (CYNO)

Cynosure, Inc. engages in the development, manufacture, and marketing of aesthetic treatment systems that are used by physicians and other practitioners to perform noninvasive procedures. Its systems incorporate a range of laser and other light-based energy sources, including Alexandrite, pulse dye, Nd:YAG, and diode lasers, as well as intense pulsed light. The company's products include Apogee Elite system for hair removal; Cynergy system for the treatment of vascular lesions; TriActive LaserDermology system for the temporary reduction of the appearance of cellulite; Affirm system for anti-aging, including treatments for wrinkles, skin texture, skin discoloration, and skin tightening; and Smartlipo system for LaserBodySculpting and the removal of unwanted fat. It primarily offers its products to the dermatology, plastic surgery, and general medical markets. Cynosure markets its products through direct sales force in North America, Europe, Japan, and China, as well as through international distributors in other countries. The company was founded in 1991 and is headquartered in Westford, Massachusetts.


VISION-SCIENCES INC (VSCI)

Vision-Sciences, Inc. engages in the design, development, manufacture, and marketing of endoscope products for the medical device and industrial device markets. It operates in two segments, Medical and Industrial. The Medical segment supplies flexible endoscopes and disposable Slide-On EndoSheath systems to the ear-nose-throat (ENT), gastrointestinal, urology, and pulmonary markets. EndoSheaths are primarily used by health-care providers to cover the insertion tube of flexible endoscopes, such as ENT endoscopes, Trans-Nasal Esophagoscopes, sigmoidoscopes, cystoscopes, and bronchoscopes. The Industrial segment manufactures and repairs flexible endoscopes, such as nasopharyngolaryngo endoscopes, the ENT-2000, and ENT-1000 for the ENT market; and trans-nasal diagnostic esophagoscope, trans-nasal therapeutic esophagoscope, cystoscope, sigmoidoscope, and bronchoscope. It also designs, manufactures, and markets flexible endoscopes for industrial markets, primarily aircraft maintenance, jet engine manufacturing, and defense. Vision-Sciences offers its disposable EndoSheaths, flexible endoscopes, and related products primarily to otolaryngologists, urologists, gastroenterologists, pulmonologists, and primary care physicians in hospitals, medical clinics, and physicians' offices in the united States and internationally. The company was incorporated as Machida Incorporated in 1987 and changed its name to Vision-Sciences, Inc. in 1990. Vision-Sciences is based in Natick, Massachusetts.


VNUS MEDICAL TECHNOLOGIES INC (VNUS)

VNUS Medical Technologies, Inc. engages in the development, marketing, and sale of medical devices for the treatment of venous reflux disease. Venous reflux disease, a progressive condition caused by incompetent vein valves, is characterized by the poor return of blood from the legs to the heart. The company's primary product line, the Closure system, consists of a proprietary radio-frequency (RF) generator, and proprietary disposable endovenous catheters to close diseased veins through the application of temperature-controlled RF energy. It also sells accessory products, such as sterile supply kits and other accessory supplies. The company sells its products to hospitals, physicians, and physician groups through direct sales organizations in the United States and through distributors in international markets. VNUS Medical Technologies was founded in 1995 and is headquartered in San Jose, California.


CELSION CORPORATION (CLN)

Celsion Corporation, a biotechnology company, engages in the development and commercialization of treatment systems for cancer and other diseases using focused heat energy in combination with other therapeutic devices, heat-activated drugs, or heat-activated genes. The company markets Prolieve Thermodilatation system for the treatment of Benign Prostatic Hyperplasia, a chronic condition of enlargement of the prostate common in older men. In addition, it conducts Phase I clinical trials of a treatment for liver cancer, using a combination of ThermoDox, its proprietary encapsulation of doxorubicin, a common cancer-treating drug, in a heat-activated liposome; and Phase I clinical trials of a treatment for prostate cancer, using a combination of ThermoDox and heat from a modified Prolieve device. In addition, it develops gene-based cancer repair inhibitor, which is in late stage preclinical development. Celsion Corporation has a strategic alliance with Boston Scientific Corporation to market Prolieve system. The company was founded by Augustine Y. Cheung in 1982 under the name Cheung Laboratories, Inc. It changed its name to Celsion Corporation in 1998. Celsion Corporation is based in Columbia, Maryland.


SONIC INNOVATIONS INC (SNCI)

Sonic Innovations, Inc., engages in the design, development, manufacture, and marketing of digital hearing aids worldwide. It also offers auditory testing equipment that automates commonly performed hearing tests. The company provides various digital hearing aid products, including Natura 3, Natura 2SE, Altair, Tribute, and Quartet in a range of models, such as behind-the-ear, in-the-ear, half-shell, in-the-canal, minicanal, and completely-in-the-canal. Sonic Innovations provides its products primarily to hearing care professionals and hearing impaired consumers. It sells products directly in North America; and through distributors in Germany, Denmark, the Netherlands, Austria, and England, as well as through retail clinics in Australia and Switzerland. The company is based in Salt Lake City, Utah.


KINETIC CONCEPTS INC (KCI)

Kinetic Concepts, Inc. (KCI), a global medical technology company, engages in the design, manufacture, marketing, and service of a range of proprietary products. Its product line includes wound healing and tissue repair systems, critical care therapies, bariatric care, and wound treatment and prevention. Its wound healing and tissue repair systems product line incorporates its vacuum assisted closure (VAC)technology to meet the needs of specific care settings and wound or patient requirements, including acute care setting, serious trauma wounds, failed surgical closures, amputations, and serious pressure ulcers. KCI's critical care therapies product line includes kinetic therapy products and prone therapy products for treating pulmonary complications, which provide mobility to patients who cannot mobilize themselves. Its bariatric care products provide a range of therapy options and support, and serve as a chair, weight scale, and x-ray table for obese patients. In addition to therapy, it provides a risk management platform for patients weighing approximately 850 pounds. KCI's wound treatment and prevention product line offers therapeutic surfaces for wound treatment and prevention, providing pressure relief, pressure reduction, pulsation, alternating pressure, and an automated wound care turn of approximately 20 degrees for the treatment of pressure sores, burns, ulcers, skin grafts, and other skin conditions. In addition, it rents its VAC systems and therapeutic surfaces. As of December 31, 2004, the company served approximately 2,300 medium to large hospitals in the United States through its network of 138 U.S. and 69 international service centers. It has direct operations in the United States, Canada, western Europe, Australia, Singapore, and South Africa; and conducts additional business through distributors in Latin America, the Middle East, eastern Europe, and Asia. KCI was founded in 1976 by James R. Leiningerand and is headquartered in San Antonio, Texas.


REGENERATION TECHNOLOGIES INC (RTIX)

Regeneration Technologies, Inc. and its subsidiaries engage in the processing and sterilization of human tissue into allograft implants for orthopedic, oral maxillofacial, urinary, and cardiovascular surgeries. It processes human musculoskeletal and other tissues, including bone, cartilage, tendon, ligament, pericardial, and cardiovascular tissue in producing allograft implants. These tissues are used by surgeons to repair and promote the healing of various bone and other tissue defects, including spinal vertebrae repair, musculoskeletal reconstruction, fracture repair, repairs to the jaw and related tissues, and heart valve disorders. The company's processed Allografts include its patented MD Series Threaded Cortical Bone Dowels, Cornerstone Machined Allografts, Tangent Impacted Cortical Wedges, Opteform and Optefil allograft pastes, Osteofil/Regenafil injectable bone paste, and Precision Graft Cortical Rings. Regeneration Technologies provides its portfolio of products in a range of markets, including spinal, sports medicine, cardiovascular, and other general orthopedic applications. It distributes its products in the United States, Korea, and Europe. The company was incorporated in 1997 and is headquartered in Alachua, Florida.


ALIGN TECHNOLOGY INC (ALGN)

Align Technology, Inc. engages in the development, manufacture, and marketing of Invisalign, a method for treating malocclusion, or the misalignment of teeth. Its product, Invisalign, has two primary components, ClinCheck and Aligners. ClinCheck is an Internet-based application that enables orthodontists to simulate treatment in 3-D by modeling stages of tooth movement. Aligners are thin, invisible, and removable dental appliances that correspond to each stage of the ClinCheck simulation, and are used to straighten teeth. It markets its product directly to dental professionals and to general practitioner dentists through its training and certification programs, and by direct mail campaigns. The company operates in the United States, Canada, Europe, Asia-Pacific, and Latin America. Align Technology was founded by Zia Chishti and Kelsey Wirth in 1997. The company is headquartered in Santa Clara, California.


GIVEN IMAGING LTD (GIVN)

Given Imaging, Ltd. engages in the development, manufacture, and marketing of diagnostic products for disorders of the gastrointestinal tract. Its Given System, a wireless imaging system uses a miniaturized video camera contained in a capsule, referred to as PillCam capsule that is ingested by the patient and delivers high quality color images in a painless and noninvasive manner. The Given System components include a single-use, disposable PillCam color-imaging capsule that is ingested by the patient; a portable data recorder and array of sensors that are worn by the patient; and a computer workstation with a software for downloading, processing, and analyzing recorded data. The company has strategic marketing and sales alliance with Ethicon Endo-Surgery. The company was founded by Gavriel D. Meron in 1998. Given Imaging is headquartered in Yoqneam, Israel.


AMERICAN MEDICAL ALERT CORP (AMAC)

American Medical Alert Corp. (AMAC) provides remote health monitoring devices and 24/7 communication services for senior, disabled, and chronically ill populations. Its products and services include personal emergency response systems, electronic medication reminder devices, disease management monitoring appliances, and 24/7 medical on-call and emergency response monitoring. The company's products and services are primarily marketed to the healthcare community, including home care, durable medical equipment, medical facility, hospice, pharmacy, managed care, and other healthcare oriented organizations. The company has strategic partnerships with AMTELCO, Health Hero Network, Inc., and Kshema Technologies. AMAC was incorporated in 1981 and is based in Oceanside, New York.


NXSTAGE MEDICAL INC (NXTM)

NxStage Medical, Inc., a medical device company, engages in the development, manufacture, and marketing of systems for the treatment of end-stage renal disease and acute kidney failure in the United States. The company's primary product includes NxStage System One, a portable hemodialysis system, which is designed to provide physicians and patients flexibility in prescribing and delivering hemodialysis therapy. It offers its products primarily to dialysis clinics, as well as other hospitals that treat acute kidney failure and fluid overload. The company was incorporated in 1998 as QB Medical, Inc. It later changed its name to NxStage Medical, Inc. The company is headquartered in Lawrence, Massachusetts.


ARTHROCARE CORPORATION (ARTC)

Arthrocare Corporation engages in the design, development, manufacture, and marketing of medical devices used in soft-tissue surgery. Its products are based on its patented Coblation technology, a soft-tissue surgical controlled ablation technology. The company operates through five segments: Sports Medicine, Arthrocare Spine, ENT, Arthrocare Coblation Technologies (ACT), and AngioCare. The Sports Medicine segment offers surgical instruments for use in various arthroscopic procedures, such as shoulder, knee, elbow, ankle, wrist, hip, and nontraumatic soft tissue injuries. The ArthroCare Spine segment provides procedures for spinal disc decompression and soft tissue removal, as well as bone access and biopsy, and percutaneous injection of bone cement and bone augmentation in the spine. The ENT segment commercializes its ear, nose, and throat surgery products for use in general head, neck, and oral surgical procedures, which include sinus surgery, the treatment of snoring, reduction of nasal turbinates, adenoidectomy, and tonsillectomy. It also provides Visage products for use in various cosmetic surgery procedures. The ACT segment develops and manufactures products as an original equipment manufacture supplier of surgical instruments to companies in general surgery, cardiology, urology, and gynecology markets. The AngioCare segment develops various cardiovascular applications. These products enable surgeons to ablate, shrink, sculpt, cut, or aspirate, and suction soft tissue, as well as to seal small bleeding vessels with one surgical system. The company sells its products through a combination of distributors supported by regional sales mangers, a direct sales force, and corporate partners in the United States and Europe, as well as in Japan. It also distributes through relationships with distributors of arthroscopy products in Europe, South Africa, South and Central America, and Russia. ArthroCare was founded in 1993 and is headquartered in Austin, Texas.


MEDICAL ACTION INDUSTRIES INC (MDCI)

Medical Action Industries, Inc. engages in the development, manufacture, marketing, and supply of medical and surgical disposable products. It also manufactures and supplies collection systems for the containment of medical waste; minor procedure kits and trays; and sterile operating room towels and sterile laparotomy sponges. The company sells its products principally in the United States to acute care facilities; physician, dental, and veterinary offices; out-patient surgery centers; and long-term care facilities. Its products are marketed by its direct sales personnel, distributors, and manufacturers' representatives. In addition, the company manufactures its products under private label programs to other distributors and medical suppliers. Medical Action Industries was incorporated in 1977 and is headquartered in Hauppauge, New York.


POSSIS MEDICAL INC (POSS)

Possis Medical, Inc. engages in the development, manufacture, and marketing of medical devices for the cardiovascular and vascular treatment markets. Its primary product is AngioJet Rheolytic Thrombectomy System, a nonsurgical, minimally invasive catheter system used for blood clot removal from native coronary arteries, leg arteries, coronary bypass grafts, and AV dialysis access grafts. The company offers its system to interventional cardiologists, interventional radiologists, vascular surgeons, nephrologists, and osteopaths. It also offers XMI, XMI-RX, XMI RX +, Spiroflex, XVG, Xpeedior, DVX, and AVX line of catheters. The company was founded in 1952 and is headquartered in Minneapolis, Minnesota.


HOLOGIC INC (HOLX)

Hologic, Inc. engages in the development, manufacture, and supply of diagnostic and medical imaging systems for serving the healthcare needs of women. It focuses on mammography and bone densitometry. The company's mammography products include the Selenia full field digital mammography system and a series of screen-film mammography systems, breast biopsy image guidance systems, and other systems. Its osteoporosis assessment products consist of a family of QDR X-ray bone densitometers; and the Sahara Clinical Bone Sonometer, an ultrasound device that assesses the bone density of the heel. Hologic also offers Fluoroscan mini C-arm imaging systems for orthopedic surgeons to perform minimally invasive surgical procedures on a patient's extremities, such as the hand, wrist, knee, foot, and ankle. In addition, it provides digital detector products for original equipment manufacturers to incorporate into their own equipment, as well as minimally invasive stereotactic breast biopsy guidance systems, such as MultiCare Platinum prone breast biopsy table and the StereoLoc II upright attachment that provide an alternative to open surgical biopsy. Further, the company sells, distributes, and services complementary products that are developed and manufactured by other original equipment manufacturers. Its customers include hospitals, imaging clinics, and private practices, as well as healthcare organizations and pharmaceutical companies. The company sells and services its products through a combination of direct sales and service force, and a network of independent distributors in the United States and Belgium. Hologic was founded by S. David Ellenbogen and Jay A. Stein. The company was incorporated in 1985 and is headquartered in Bedford, Massachusetts.


RESPIRONICS INC (RESP)

Respironics, Inc. engages in the design, development, manufacture, and marketing of medical devices used primarily for the treatment of patients suffering from sleep and respiratory disorders. Its products are used primarily in the home and in hospitals, as well as emergency medical settings and alternative care facilities. The company's primary product lines include homecare products and hospital products. Its homecare products include sleep apnea products, including continuous positive airway pressure devices and bi-level positive airway pressure devices used in the home for the treatment of obstructive sleep apnea; respiratory devices, including bi-level noninvasive ventilation products that provide positive airway pressure into a patient's airway to supplement the patient's own breathing; invasive portable volume ventilation products used in the home; and home oxygen products. The company's hospital products include therapeutic devices that assist or control a patient's ventilation, such as bi-level noninvasive ventilation products and critical care ventilation products that can deliver noninvasive and invasive ventilation; cardio-respiratory monitoring products that provide information about a patient's condition; and traditional respiratory drug delivery products. In addition, the company offers respiratory drug delivery products, and children's medical ventures infant management and developmental care products. It sells its products to home medical equipment service providers and hospital distributors located in Europe, Africa, the Middle East, Latin America, the Far East, and Asia Pacific. The company markets its products through homecare, hospital, respiratory drug delivery, and international sales organizations. Respironics was founded in 1976 and is based in Murrysville, Pennsylvania.


STEREOTAXIS INC (STXS)

Stereotaxis, Inc. engages in the design, manufacture, and marketing of cardiology instrument control system for the interventional treatment of coronary artery disease and arrhythmias. It offers Stereotaxis System, which is a remote-controlled magnetic instrument control and navigation platform that allows physicians to navigate catheters, guidewires, and stent delivery devices through the blood vessels and chambers of the heart to treatment sites. The system comprises NIOBE cardiology magnet system, NAVIGANT advanced user interface, CARDIODRIVE automated catheter advancer, and disposable interventional devices. In addition, the company markets and sells various disposable interventional devices, including catheters, guidewires, and stent delivery devices for use in conjunction with its system. Stereotaxis offers its products primarily in the United States and Europe. It has alliances with Siemens AG Medical Solutions, Philips Medical Systems, and Biosense Webster, Inc. The company was incorporated in 1990 and is headquartered in St. Louis, Missouri.


MINE SAFETY APPLIANCES COMPANY (MSA)

Mine Safety Appliances Company engages in the development, manufacture, and supply of equipment and systems for worker and plant protection in North America, Europe, and internationally. The company primarily operates in two divisions, Safety Products and Instruments. The Safety Products division offers personal protective products, such as filtering respirators, self-contained breathing apparatus, hard hats, clothing, hearing protectors, nonprescription protective eyewear and face shields, and fire and military helmets. The Instrument division offers hand-held and permanent instruments, including gas detection instruments, thermal imaging cameras, and flame detectors and open-path infrared gas detectors. It also offers fall protection equipment, such as confined space equipment, harnesses/fall arrest equipment, lanyards, and lifelines. The company's products are used in the fire service, homeland security, construction, and other industries, as well as by the military. Mine Safety Appliances Company was established in 1914 and is headquartered in Pittsburgh, Pennsylvania.


MISONIX INC (MSON)

Misonix, Inc., through its subsidiaries, engages in the design, manufacture, and marketing of ultrasonic medical devices primarily in the United States and internationally. The company operates in two segments Laboratory and Scientific Products, and Medical Devices. The Laboratory and Scientific Products segment offers Sonicator ultrasonic liquid processors for use in the scientific and industrial markets; Aura ductless fume enclosures for filtration of gaseous contaminates; Labcaire Autoscope and Guardian endoscope disinfectant systems for the abatement of air pollution, and the Mystaire wet scrubber. The Medical Devices segment provides Auto Sonix ultrasonic cutting and coagulatory system, refurbishing revenues of ultrasound systems and replacement transducers for the medical diagnostic ultrasound industry, ultrasonic lithotriptor, ultrasonic neuroaspirator used for neurosurgery, and soft tissue aspirator used primarily for the cosmetic surgery market. The company sells its products to research and clinical laboratories, industrial markets, such as paint, pigment, ceramic, and pharmaceutical manufacturers; semiconductor manufacturing, chemical processing, and pharmaceuticals industries. Its customers include end users, such as doctors, hospitals, and distributors. The company markets its products through direct salespersons, distributors, manufacturing representatives, and catalog listings. Misonix was organized in 1959 and is based in Farmingdale, New York.


SMITH & NEPHEW SNATS INC (SNN)

Smith & Nephew plc engages in the development, manufacture, and marketing of medical devices worldwide. It operates in three segments: Orthopedics, Endoscopy, and Advanced Wound Management. The Orthopedic segments comprises reconstructive joint implants that include hip, knee, and shoulder joints, as well as ancillary products, such as bone cement and mixing systems used in cemented reconstructive joint surgery; trauma products that consists of internal and external fixation devices used in the stabilization of severe fractures; and associated clinical therapies, such as bone growth stimulators and a joint fluid therapy product applied in orthopedic office or clinic setting. It also operates mobile training centers that offer training to surgeons in the U.S. The Endoscopy segment develops and commercializes a range of endoscopic techniques, including fluid management and insufflation equipment for surgical access; digital cameras, digital image capture, central control, multimedia broadcasting, scopes, light sources, and monitors to assist with visualization; radiofrequency wands, electromechanical and mechanical blades, and hand instruments for resecting tissue; and specialized devices, fixation systems, and bioabsorbable materials to repair damaged tissue. It also offers educational programs for surgeons to treat and repair soft tissues, articulating joints, spinal discs, and vascular structures. The Advanced Wound Management segment supplies a range of products and clinical support services for the treatment of chronic and acute skin wounds. Smith & Nephew offers its products primarily to doctors, hospitals, and other healthcare facilities in the United States, Canada, the United Kingdom, Germany, Japan, Australia, France, Italy, New Zealand, and Ireland. The company was founded in 1856 and is headquartered in London.


ZOLL MEDICAL CORPORATION (ZOLL)

ZOLL Medical Corporation engages in designing, manufacturing, and marketing noninvasive resuscitation devices and related software solutions in the United States and internationally. The company also offers software that automates the documentation and management of both clinical and nonclinical information. ZOLL's cardiac resuscitation products include M Series defibrillators, which offers data management, diagnostic 12-lead ECG with interpretive statement, GEMS muse cardiology information system, Pulse oximetry, capnography, and noninvasive blood pressure measurement for both hospital and prehospital markets; critical care transport defibrillators; AED plus automated external defibrillators; biphasic waveforms; and disposable electrodes, such as pro-padz biphasic multifunction electrodes and CPR-D Padz electrode for use with its resuscitation devices. It offers its products for pacing, defibrillation, circulation, ventilation, and fluid resuscitation. The company's products enable healthcare professionals, emergency medical service providers, and first responders to diagnose and treat victims of trauma, as well as sudden cardiac arrest. ZOLL Medical markets its products through sales and managerial staff, as well as through distributors and other indirect channels in the hospital, EMS, and public access market. The company was incorporated in 1980 and is headquartered in Chelmsford, Massachusetts.


CRYOLIFE INC (CRY)

CryoLife, Inc. engages in the preservation and distribution of human tissues for cardiovascular, vascular, and orthopedic transplant applications. The company also engages in the development and commercialization of implantable medical devices, including its BioGlue Surgical Adhesive (BioGlue); the CryoLife-O'Brien aortic heart valve, a glutaraldehyde-fixed stentless porcine heart valve; and SynerGraft processed bovine vascular grafts for use as arteriovenous access devices. It distributes preserved human cardiovascular, vascular, and orthopedic tissue in the United States, Canada, and Europe. CryoLife distributes BioGlue in the United States and Europe for vascular applications, as well as for pulmonary indications, such as the repair of air leaks in lungs, and soft tissue repair procedures. The company markets the SynerGraft processed bovine vascular graft in Europe and the Middle East. It markets its CryoLife-O'Brien aortic heart valve in Europe and certain other territories outside the U.S. CryoLife was founded in 1984. The company is headquartered in Kennesaw, Georgia.


SPECTRANETICS CORPORATION (SPNC)

The Spectranetics Corporation, a medical device company, engages in the development, manufacture, and marketing of single-use medical devices used in minimally invasive surgical procedures within the cardiovascular system in conjunction with its proprietary excimer laser system. Its excimer laser system includes the CVX-300 laser unit; and various fiber-optic delivery devices, including disposable catheters and sheaths. This system is approved in the United States and Europe for use in multiple, minimally invasive cardiovascular applications. The excimer laser system is used in complex atherectomy procedures to open clogged or obstructed arteries in the coronary vascular system. It is also used to remove lead wires from patients with implanted pacemakers or cardioverter defibrillators, which are electronic devices that regulate the heartbeat. The company sells its products to customers in Canada, Mexico, South America, the Pacific Rim, Australia, Europe, and the Middle East. Spectranetics was founded by Robert Golobic and Johan Sverdrup in 1984. The company is headquartered in Colorado Springs, Colorado.


CONMED CORPORATION (CNMD)

CONMED Corporation, a medical technology company, offers instruments, implants, and video equipment for arthroscopic sports medicine, as well as powered surgical instruments, such as drills and saws for orthopedic, otolaryngologic, neurosurgery, and other surgical specialties. The company develops, manufactures, and supplies radio frequency electrosurgery systems that are used to cut and cauterize tissue in various types of surgical procedures worldwide; endosurgery products, such as trocars, clip appliers, scissors, and surgical staplers; and electrocardiogram electrodes for heart monitoring and other patient care products. It also offers integrated operating room systems and equipment. The company's CONMED Endoscopic technologies offer a portfolio of disposable products used by gastroenterologists to diagnose and treat diseases of the digestive tract. Its products are used in various clinical settings, such as operating rooms, surgery centers, physicians' offices, and hospitals. The company distributes its products through medical specialty distributors and surgeons to hospitals and other healthcare institutions. CONMED was incorporated in 1970. The company was founded by Eugene R. Corasanti. CONMED Corporation is headquartered in Utica, New York.


WRIGHT MEDICAL GROUP INC (WMGI)

Wright Medical Group, Inc. (WMGI), an orthopaedic medical device company, engages in the design, manufacture, and marketing of reconstructive joint devices and biologics products. Its primary knee reconstruction product includes ADVANCE Knee System. The company offers CONSERVE family of hip reconstruction products in the areas of bone-conserving implants, total hip reconstruction, revision replacement implants, and limb preservation. WMGI also offers a line of biologics products that are used to replace damaged or diseased bone, to stimulate bone growth, and to provide other biological solutions for surgeons and their patients. In addition, it provides extremity products for the hand, wrist, elbow, shoulder, foot, and ankle in various markets worldwide. The company sells its products in the United States, Europe, Asia, Africa, South America, and Australia. Wright Medical Group, formerly known as Wright Acquisition Holdings, Inc., was founded in 1950 and is headquartered in Arlington, Tennessee.


ALLIED HEALTHCARE PRODUCTS INC (AHPI)

Allied Healthcare Products, Inc. manufactures respiratory care products, medical gas equipment, and emergency medical products used in various hospital and alternate care settings. Its respiratory care product line includes respiratory care/anesthesia products, including air compressors, calibration equipment, humidifiers, croup tents, equipment dryers, and respiratory disposable products; and home respiratory care products, including aluminum oxygen cylinders, oxygen regulators, pneumatic nebulizers, and portable suction equipment. The company's medical gas equipment product line includes construction products, such as in-wall medical system components, central station pumps and compressors, and headwalls; regulation devices and suction equipment, such as flowmeters, vacuum regulators, and pressure regulators, as well as related adapters, fittings, and hoses that measure, regulate, monitor, and enable transfer of medical gases from walled piping or equipment to patients in hospital rooms, operating theaters, or intensive care areas; and disposable oxygen and gas cylinders. Its emergency medical product line includes respiratory/resuscitator products, including demand resuscitation valves, portable resuscitation systems, bag masks and related products, emergency transport ventilators, precision oxygen regulators, minilators, multilators, and humidifiers; and trauma patient handling products, including spine immobilization products, pneumatic anti-shock garments, and trauma burn kits. Allied Healthcare sells its products to respiratory care/anesthesia product distributors, hospital construction contractors, emergency medical equipment dealers, and hospitals. The company markets its products through dealers, agents, and exporters in the United States, Canada, Mexico, central and South America, Europe, the Middle East, and the Far East. Allied Healthcare was founded in 1979 and is headquartered in St. Louis, Missouri.


STERIS CORPORATION (STE)

STERIS Corporation engages in the development, manufacture, and marketing of infection prevention, contamination control, microbial reduction, and surgical and critical care support products and services for healthcare, scientific, research, industrial, and government customers worldwide. It operates through three segments: Healthcare, Life Sciences, and STERIS Isomedix Services. The Healthcare segment offers capital equipment, including general and specialty surgical tables, surgical and examination lights, equipment management systems, operating room storage cabinets, warming cabinets, scrub sinks, and other products and accessories; technologies for sterilizing medical devices and instruments; automated washer/disinfector systems; infection prevention consumables and supplies; and skin care and hand hygiene solutions for use in surgical environments, critical care environments, emergency departments, gastrointestinal environments, sterile processing environments, and in infection control processes. The Life Sciences segment provides capital equipment and accessories, washers, sterilizers, infection prevention consumables and supplies, and skin care and hand hygiene solutions for pharmaceutical and research, defense and aerospace, and industrial decontamination markets. The Isomedix Services segment offers contract sterilization, microbial reduction, and materials modification services to companies that supply products to the healthcare, industrial, and consumer product industries. The company sells products through its sales force and distributors. STERIS Corporation was founded in 1985 and is headquartered in Mentor, Ohio.


BSD MEDICAL CORPORATION (BSM)

BSD Medical Corporation engages in the development, manufacture, marketing, and servicing of systems used for the treatment of cancer and other diseases worldwide. Its systems deliver precision-focused radio frequency (RF) and microwave energy into diseased sites of the body, heating them to specified temperatures as required by various medical therapies. The company's products include BSD-500 systems that are used to deliver either superficial or interstitial hyperthermia therapy or both; and BSD-2000, which noninvasively delivers RF energy to cancerous tumors. The superficial hyperthermia therapy treats cancerous tumors located within a few centimeters of the surface of the body, such as melanoma and recurrent breast cancer; internal or interstitial hyperthermia therapy treats tumors in combination with internal radiation therapy; and deep hyperthermia therapy treats tumors located deep within the body, including many problematic cancer sites located in the pelvis, abdomen, and chest areas. It also offers microwave thermal therapy for the treatment of symptoms associated with enlarged prostate. The company sells its products primarily to clinics, hospitals, and institutes. BSD Medical Corporation was founded in 1978 and is based in Salt Lake City, Utah.


ST. JUDE MEDICAL INC (STJ)

St. Jude Medical, Inc. engages in the development, manufacture, and distribution of cardiovascular medical devices for the cardiac rhythm management (CRM), cardiac surgery (CS), and cardiology and vascular access (C/VA) therapy areas worldwide. It offers a range of CRM products, such as bradycardia pacemaker systems, tachycardia implantable cardioverter defibrillator systems, and electrophysiology catheters; various CS products, including mechanical and tissue heart valves, valve repair products, and epicardial ablation systems; and C/VA products, that include vascular closure devices, angiography catheters, guidewires, and hemostasis introducers. The company markets and sells its products through direct sales force and independent distributors in the United States, Europe, and Japan, as well as in Canada, Latin America, Australia, New Zealand, and the Asia-Pacific region. St. Jude Medical was founded in 1976 and is headquartered in St. Paul, Minnesota.


NATUS MEDICAL INCORPORATED (BABY)

Natus Medical Incorporated engages in the development, manufacture, and marketing of products for the detection, monitoring, treatment, and tracking of common medical disorders in newborns. The company's product line includes ALGO Newborn Hearing Screener, a product line for hearing screening; neoBLUE LED Phototherapy device, a medical device for the treatment of newborn jaundice; Neometrics line of diagnostic reagents, used for newborn metabolic screening; neonatal heat shields and oxygen delivery hoods designed to provide a stable environment of oxygen and humidity for newborns with special needs; and MiniMuffs neonatal noise attenuators, which is designed to decrease noise exposure for babies in neonatal-intensive care units. The company offers its products to hospitals, clinics, laboratories, physicians, nurses, audiologists, and governmental agencies. Its sells its products through a direct sales force in the United States, through its wholly owned subsidiaries in the United Kingdom and Japan, and through distributors in 50 other countries. Natus Medical was incorporated in 1987 and is headquartered in San Carlos, California.


SPAN-AMERICA MEDICAL SYSTEMS INC (SPAN)

Span-America Medical Systems, Inc. engages in manufacturing and distributing various polyurethane foam products for the medical and custom products markets in the United States. Its medical products consist of therapeutic support surfaces, including polyurethane foam mattress overlays, nonpowered replacement mattresses, and powered replacement mattresses; patient positioners; and seating products. The company's custom products include two product lines, consumer products and industrial products. The consumer product line consists of convoluted and geo-mattress overlays, and pillows for the consumer bedding market. These products are marketed to retailers in North America. The industrial product line includes foam packaging and cushioning materials. The company also produces foam products for flotation, sound insulation, and gasketing purposes. Its wound care products serve in the treatment or prevention of pressure ulcers known as bed sores or diabetic ulcers. The company markets its products through sales representatives and manufacturers' representatives to sports equipment, automotive, photographic film, durable goods, and electronics industries, primarily in the southeastern United States. Span-America Medical Systems was founded by Don Spann. The company was incorporated in 1970. Span-America Medical Systems is headquartered in Greenville, South Carolina.


MEDTRONIC INC (MDT)

Medtronic, Inc. engages in the development and manufacture of medical devices for the treatment of various diseases. Cardiac Rhythm Management segment offers implantable devices, external defibrillators, leads, ablation products, electrophysiology catheters, navigation systems, and information systems for heart rhythm disorders and heart failure. Spinal, Ear, Nose, and Throat and Surgical Navigation Technologies segment provides thoracolumbar cervical and interbody, and spinal devices; bone growth substitutes; surgical navigation tools; and surgical products for spinal, ear, nose, and throat disorders. Neurological and Diabetes segment offers implantable neurostimulation systems, external and implantable drug administration devices, neurosurgery products, urology products, gastroenterology products, hydrocephalic shunts and drainage devices, surgical instruments, functional diagnostic and sensing equipment, and medical systems for neurological disorders, diabetes, gastroentrological disorders, and urological disorders. Vascular segment provides coronary, endovascular, and peripheral stents and related delivery systems; stent graft systems; distal embolic protection systems; and balloon angioplasty catheters, guide catheters, guidewires, and diagnostic catheters and accessories for coronary artery disease, peripheral vascular disease, and aortic aneurysms. Cardiac Surgery segment offers positioning and stabilization systems for beating heart surgery; perfusion systems; products for the repair and replacement of heart valves; surgical accessories; and epicardial ablation products. The company sells its products to physicians, hospitals, medical institutions, and group purchasing organizations worldwide, through direct sales representatives and independent distributors. Medtronic was founded in 1949 by Earl E. Bakken and Palmer J. Hermundslie. The company is headquartered in Minneapolis, Minnesota.


VOLCANO CORPORATION (VOLC)

Volcano Corporation engages in the development, manufacture, and commercialization of intravascular ultrasound (IVUS) and functional measurement (FM) products that are used for the diagnosis and treatment of vascular and structural heart disease. Its IVUS products include consoles, single-procedure disposable catheters, and advanced functionality options. The company's FM products consist of pressure and flow consoles, and single-procedure disposable pressure and flow guidewires that measure the pressure and flow characteristics of blood around plaque, thereby allowing physicians to gauge the plaque's impact on blood flow and pressure. Volcano markets its products through its direct sales force and distributors, as well as through supply and distribution agreements primarily in the United States, Japan, Europe, the Asia-Pacific, the Middle East, Latin America, and Africa to physicians and technicians. The company, formerly known as Volcano Therapeutics, Inc., was founded in 2000. Volcano Corporation is headquartered in Rancho Cordova, California.


LANGER INC (GAIT)

Langer, Inc. engages in the design, manufacture, and distribution of medical products for the orthopedic, orthotic, and prosthetic markets. The company operates in two segments, Orthopedic and Skincare. The Orthopedic segment offers a line of approximately 500 orthopedic products, including custom foot and ankle orthotic devices, prefabricated foot products, rehabilitation products, and gel-based orthopedic and prosthetics products for patients to correct, protect, and heal. The Skincare segment provides a line of approximately 50 skincare products for the medical, therapeutic, and retail markets. Its products include scar management products, and gel-based therapeutic gloves and socks for skin appearance, as well as for transmission of moisture agents, vitamins, and nutrients to the skin. Langer sells its products primarily to independent medical distributors and directly to healthcare professionals in the United States and Canada, as well as in approximately 30 other countries. It markets its products to podiatrists, orthopedists, orthopedic surgeons, dermatologists, cosmetic and plastic surgeons, occupational and physical rehabilitation professionals, prosthetists, orthotists, and various healthcare professionals. The company was formerly known as Langer Biomechanics Group, Inc. and changed its name to Langer, Inc. in 2001. Langer is headquartered in Deer Park, New York.


ESCALON MEDICAL CORP (ESMC)

Escalon Medical Corp. engages in the development, manufacture, marketing, and distribution of medical devices and pharmaceuticals in the areas of ophthalmology, diabetes, hematology, and vascular access. It provides instruments for blood cell counting and blood analysis; and supplies the reagent and other consumable materials needed to operate the instruments. The company also sells diabetic testing products, including DS5 that measures long-term glucose control in diabetic patients; and Hb-Gold, which provides for in vitro measurement of certain genetic diseases of the blood. In addition, it offers equipment for use in the field of human and veterinary hematology. The company also manufactures and markets ultrasound systems for diagnostic or biometric applications in ophthalmology, including A-Scans, B-Scans, High frequency B-Scans, and pachymeters. Further, it develops, manufactures, and markets vascular access products that include Doppler-guided vascular access assemblies used to locate desired vessels for access. Escalon Medical also provides ophthalmic surgical products to vitreoretinal ophthalmic surgeons; distributes intraocular gas products, C3F8 and SF6, which are used by vitreoretinal surgeons as a temporary tamponade in detached retina surgery; light sources, including various fiber optic probes and illuminated tissue manipulators; and CFA camera system. The company also offers viscous fluid transfer systems and related disposable syringe products, which aid in the process of injecting and extracting silicone oil. The company has license and distribution rights for Povidone-Iodine 2.5% solution, an anti-microbial to prevent ophthalmia neonatorum in newborns. It sells its product to surgeons, laboratories, medical institutions, educational institutions, and ophthalmologists. The company was incorporated in 1987 and is based in Wayne, Pennsylvania.


SHAMIR OPTICAL INDUSTRY LTD (SHMR)

Shamir Optical Industry, Ltd. engages in the development, design, manufacture, and marketing of progressive lenses and molds for the ophthalmic market. Its progressive lenses are used to treat presbyopia, a vision condition where the eye loses its ability to focus on close objects. The company also provides design services to optical lens manufacturers. In addition, it develops software for the design of progressive lenses, as well as software tools for research and development, and production requirements. These tools include Eye Point Technology software, which simulates human vision. It sells its progressive lenses to optical laboratories, retail chains, buying groups, and opticians principally in Israel and other Asian countries, the United States, and Europe. The company was founded by Giora Ben-Zeev in 1970 and is headquartered in Upper Galilee, Israel. Shamir Optical Industry, Ltd. is approximately 58% owned by Kibbutz Shamir.


INVACARE CORPORATION (IVC)

Invacare Corporation engages in the design, manufacture, and distribution of health care products. It offers rehab, standard, respiratory, distributed, and other products. Invacare's rehab products include power wheelchairs, custom manual wheelchairs, personal mobility, and seating and positioning products. The company's standard products include manual wheelchairs, personal care, home care beds, low air loss therapy products, and patient transport. Its respiratory products include oxygen concentrators, nebulizer compressors and respiratory disposables, sleep therapy products, and portable compressed oxygen systems. Invacare's distributed products include ostomy, incontinence, diabetic, wound care, and miscellaneous home medical products. Its other products include accessory products, such as spare parts, wheelchair cushions, arm rests, wheels, and respiratory parts. Invacare also manufactures and distributes beds and furnishings for the nonacute care markets. The company sells its products to home health care and medical equipment providers, as well as to government agencies and distributors. Invacare distributes its products through sales force, telesales associates, and independent manufacturers' representatives and distributors. The company was founded in 1885 and is headquartered in Elyria, Ohio.


MICRUS ENDOVASCULAR CORPORATION (MEND)

Micrus Endovascular Corporation engages in the development, manufacture, and marketing of implantable and disposable medical devices used in the treatment of cerebral vascular diseases. Its product line is an endovascular system that enables a physician to gain access to the brain in a minimally invasive manner through the vessels of the circulatory system. The company's product line includes various components, including micruSphere spherical microcoils; heliPaq, ultiPaq, and interPaq microcoils; and microcatheters and guidewires. Micrus Endovascular is also developing a cerebral stent for use in the endovascular treatment of aneurysms. In addition, the company sells accessory devices and products used in conjunction with microcoils to treat cerebral aneurysms. The company's products are used by interventional neuroradiologists and neurosurgeons primarily to treat cerebral aneurysms in the brain responsible for hemorrhagic stroke. The company was formed in 1996 by Joseph Horton. It was formerly known as Micrus Corporation and changed its name to Micrus Endovascular Corporation in May 2005. Micrus Endovascular is headquartered in Sunnyvale, California.


ORTHOFIX INTERNATIONAL N.V (OFIX)

Orthofix International N.V. primarily engages in the design, development, manufacture, marketing, and distribution of medical equipment for the orthopedic products market. Its products include external and internal fixation devices used in fracture treatment, limb lengthening, and bone reconstruction; noninvasive stimulation products for spinal fusions and to treat nonunion fractures; and bracing products used for ligament injury prevention, pain management, and protection of surgical repair to promote faster healing. The company's products also include a device for improving venous circulation, cold therapy, other pain management products, bone cement and devices for removal of the bone cement used to fix artificial implants, and airway management products used in anesthesia applications. Orthofix International offers its orthopedic products primarily to spine, reconstruction, and trauma sectors. It distributes products directly and indirectly through independent distributors in the United States, the United Kingdom, Ireland, Italy, Germany, Switzerland, Austria, France, Belgium, Mexico, Brazil, and Puerto Rico. The company was founded in 1979 and is based in Curacao, the Netherlands.


ZIMMER HOLDINGS INC (ZMH)

Zimmer Holdings, Inc. and its subsidiaries engage in the design, development, manufacture, and marketing of reconstructive orthopaedic implants in the United States and internationally. The company offers reconstructive orthopaedic implants, including joint and dental, spinal implants, and trauma products, as well as related orthopaedic surgical products. Its orthopaedic reconstructive implants restore joint function lost due to disease or trauma in joints, such as knees, hips, shoulders, and elbows. The company's dental reconstructive implants restore function and aesthetics in patients that have lost teeth due to trauma or disease. Its spinal implants are utilized by orthopaedic surgeons and neurosurgeons in the treatment of degenerative diseases, deformities, and trauma in all regions of the spine. The company's trauma products are devices, which are used primarily to reattach or stabilize damaged bone or tissue to support the body's natural healing process. Zimmer Holdings' related orthopaedic surgical products include surgical supplies and instruments that are designed to aid in orthopaedic surgical procedures. In addition, the company markets an array of sports medicine products. Its primary customers include musculoskeletal surgeons, neurosurgeons, oral surgeons, dentists, hospitals, distributors, and healthcare dealers. The company markets and sells its products through its direct sales force, as well as through stocking distributors. Zimmer Holdings is headquartered in Warsaw, Indiana.


THERAGENICS CORPORATION (TGX)

Theragenics Corporation provides brachytherapy and wound closure products. It operates through two segments, brachytherapy seed and CP Medical Wound Closure and Medical Products. The brachytherapy seed segment offers TheraSeed, a rice-sized palladium-103 device, used treat solid localized tumors, such as prostate cancer. This segment also manufactures and distributes I-Seed, an iodine-125 based medical device for the treatment of prostate cancer, as well as provides Intravascular Brachytherapy System that is designed to prevent restenosis or renarrowing of arteries. CP Medical Wound Closure and Medical Products segment manufactures and supplies sutures, cardiac pacing cables, brachytherapy needles/spacers/sleeves, and other related medical products for wound closure, cardiac pacing, and the general, dental, cosmetic and veterinary surgery markets. It distributes its products to physicians, hospitals, and other healthcare providers. Theragenics was incorporated in 1981 and is based in Buford, Georgia.


SYMMETRY MEDICAL INC (SMA)

Symmetry Medical, Inc. engages in the design, development, and manufacture of implants, and related instruments and cases to orthopedic device manufacturers primarily in the United States and the United Kingdom. The company offers implants for use in specific implant systems, primarily in knee and hip implant systems. Its orthopedic implants are used in reconstructive surgeries to replace or repair hips, knees, and other joints, such as shoulders, ankles, and elbows. Symmetry Medical's knee implants include a femoral component, a patella, a tibial tray, and an articulating surface and are used in total knee reconstruction, partial knee reconstruction, and revision procedures. It also produces tight tolerance femoral heads, hip stems, acetabular cups, and spiked acetabular cups used in bone conservation, total-hip reconstruction, and revision replacement procedures. Symmetry Medical also manufactures implant products for trauma, spine, and other implant systems. Its spinal implant products comprise plates and screws. The company also makes precision surgical instruments used in hip, knee, and shoulder reconstruction procedures, as well as in spinal, trauma, and other implant procedures. In addition, it provides implant-specific instruments that include customized reamers, cutting blocks, broaches, rasps, guides, and other instruments. Further, the company offers procedure-specific instruments, including hip and knee revision systems. Additionally, it produces plastic, metal, and hybrid cases. It offers orthopedic cases to store, transport, and arrange surgical instruments and related implant systems for orthopedic device manufacturers; dental cases used in dental implant and general dental procedures; and other cases for arthroscopy, osteobiologic, endoscopy, cardiovascular, ophthalmology, and diagnostic imaging, as well as ear, nose, and throat procedures. Symmetry Medical was established in 1976 and is headquartered in Warsaw, Indiana.


THERMAGE INC (THRM)

Thermage, Inc. engages in the design, development, manufacture, and marketing of radiofrequency-based equipment and disposable products for non-invasive treatment of wrinkles in the United States and internationally. It offers ThermaCool system, which uses monopolar radiofrequency energy to heat and shrink collagen, and tighten the epidermis and subcutaneous tissue while cooling and protecting the surface of the skin. The ThermaCool system includes components, such as radiofrequency generator, reusable handpiece, and a single-use ThermaTip, as well as various consumable accessories. The company markets ThermaCool system, including single-use ThermaTips to physicians through a direct sales force in the United States, as well as internationally in approximately 77 countries through a network of distributors. Its customers primarily consist of dermatologists and plastic surgeons. Thermage, Inc. was founded in 1995 and is based in Hayward, California.


EDWARDS LIFESCIENCES CORPORATION (EW)

Edwards Lifesciences Corporation provides products and technologies designed to treat advanced cardiovascular disease. It provides products and technologies to address heart valve disease, peripheral vascular disease, and critical care technologies. The company's products and technologies are categorized into five areas: heart valve therapy, critical care, cardiac surgery systems, vascular, and other distributed products. Its heart valve therapy portfolio comprises tissue heart valves and heart valve repair products that are used to replace or repair a patient's diseased or defective heart valve. In the critical care area, the company provides hemodynamic monitoring systems used to measure a patient's heart function, as well as disposable pressure transducers and central venous access products for fluid and drug delivery. The company's cardiac surgery systems portfolio consists of a diverse line of products, including oxygenators, blood containers, filters, and other disposable products used during cardiopulmonary bypass procedures, cannulae, and transmyocardial revascularization technology. Edwards Lifesciences' vascular portfolio includes a line of balloon catheter-based products, surgical clips and inserts, angioscopy equipment, artificial implantable grafts, and stents used in the treatment of peripheral vascular disease. In addition, the company's other distributed products include intra-aortic balloon pumps, pacemakers, and other products. It distributes its products through direct sales force and independent distributors primarily in the United States, Canada, and Europe. Edwards Lifesciences was incorporated in 1999 and is headquartered in Irvine, California.


CUTERA INC (CUTR)

Cutera, Inc. engages in the design, development, manufacture, and marketing of various products for use in laser and other light-based aesthetic applications. Its products enable dermatologists, plastic surgeons, gynecologists, primary care physicians, and other practitioners to offer noninvasive aesthetic treatments to their patients. The company's products are used for hair removal and the permanent reduction of hair; for the treatment of vascular lesions, including leg and facial veins; for the treatment of wrinkles using laser technology; for the treatment of benign pigmented lesions; and for dermal heating. Cutera sells its products directly in the United States, Canada, Australia, Japan, and European markets, as well as through distributors in certain countries worldwide. The company was founded in 1998 as Acme Medical, Inc. and changed its name to Altus Medical, Inc. in 1999. Further, it changed its name to Cutera, Inc. in 2004. Cutera is headquartered in Brisbane, California.


EXACTECH INC (EXAC)

Exactech, Inc. engages in the development, manufacture, marketing, distribution, and sale of orthopaedic implant devices, related surgical instrumentation, and biologic materials to hospitals and physicians in the United States and internationally. The company offers Optetrak knee system, a modular system designed to improve the movement of the knee cap, which is called patellar tracking and reduces the force between surfaces in a joint, and provides a functional range of motion. It also offers AcuMatch integrated hip system, which is designed to address the requirements for total hip replacement, including primary and revision needs. Exactech also distributes bone paste materials for use in nonspinal musculoskeletal orthopaedic procedures. Its allograft materials are distributed as Opteform and Optefil, and are used for repairing bone and filling bone defects. In addition, the company offers AcuDriver automated osteotome system, an air-driven impact hand piece that assists surgeons during joint implant revision procedures by aiding in removal of failed prostheses and bone cement; and distributes Link surgical instrumentation that can be used in various orthopaedic procedures, including shoulder, knee, spine, foot, ankle, and hip arthroplasty; and offers Cemex bone cement system featuring a self-contained delivery system. Exactech markets its orthopaedic implant products in the United States through independent sales agencies and domestic distributors. The company was co-founded by William Petty, Betty Petty, and Gary J. Miller in 1985. Exactech is headquartered in Gainesville, Florida.


SIRONA DENTAL SYSTEMS INC (SIRO)

Sirona Dental Systems, Inc. manufactures various dental equipment for dentists worldwide. Its products are offered in the following categories: Dental CAD/CAM Systems, Imaging Systems, Treatment Centers, and Instruments. Dental CAD/CAM Systems address the market for dental restorations, which includes various types of restorations, such as inlays, onlays, veneers, crowns, bridges, copings, and bridge frameworks made from ceramic, metal, or composite blocks. It offers CEramic REConstruction (CEREC) method, which is an in-office application that enables the dentist to produce restorations from ceramic material and insert them into the patient's mouth during a single appointment. Sirona also offers Inlab that scans the model received from the dentist and mills the ceramic restoration to the specifications of the captured image; and the inEos scanner, which produces 3D digital images from a single tooth up to a jaw, directly from the plaster model. Imaging Systems comprise various equipment for diagnostic imaging in the dental practice, which includes Intra-oral x-ray equipment; Panoramic x-ray equipment, including the Orthophos XG line; and Schick's CDR (computed digital radiography) system. Treatment Centers comprise a range of products from basic dentist chairs to sophisticated chair-based treatment centers with integrated diagnostic, hygiene, and ergonomic functionalities, as well as specialist centers used in preventative treatment and for training purposes. Sirona offers various instruments, including handheld and power-operated hand pieces for cavity preparation, endodontics, periodontology, and prophylaxis. The instruments are supplemented by multi-function tips, supply and suction hoses, as well as care and hygiene systems for instrument preparation. Sirona distributes its products to dental practices, clinics, and laboratories through an international network of distributors. The company was founded in 1882 and is headquartered in Long Island City, New York.


WILSON GREATBATCH TECHNOLOGIES INC (GB)

Greatbatch, Inc. engages in the development and manufacture of batteries, capacitors, feedthroughs, enclosures, and other components used in implantable medical devices. The company operates through two segments, Implantable Medical Components (IMC) and Electrochem Power Solutions (EPS). The IMC segment designs and manufactures batteries, coated electrodes, capacitors, filtered feedthroughs, enclosures, and precision components used in implantable medical devices. The EPS segment designs and manufactures batteries and battery packs for use in oil and gas exploration, oceanographic equipment, and aerospace. It sells its commercial batteries and battery packs either directly to the end user and manufacturers, who incorporate its products into other devices for resale or to distributors, who sell its products to manufacturers and end users. Greatbatch, Inc. was formerly known as Wilson Greatbatch Technologies Inc. Greatbatch was founded in 1970 and is headquartered in Clarence, New York.


DATASCOPE CORP (DSCP)

Datascope Corp. engages in the development, manufacture, and marketing of products for clinical health care markets in interventional cardiology and radiology, cardiovascular and vascular surgery, anesthesiology, emergency medicine, and critical care. The company operates in two segments, Cardiac Assist/Monitoring Products and Interventional Products/Vascular Grafts. The Cardiac Assist/Monitoring Products segment offers electronic intra-aortic balloon pumps and catheters that are used in the treatment of cardiovascular disease and electronic physiological monitors that provide for patient safety and management of patient care. The Interventional Products/Vascular Grafts segment offers vascular sealing devices, which are used to seal arterial puncture wounds to stop bleeding after cardiovascular catheterization procedures; interventional radiology products used in dialysis access; and a line of knitted and woven polyester vascular grafts and patches for reconstructive vascular and cardiovascular surgery. The company markets its products through direct sales representatives and independent distributors primarily in the United States, Europe, and Japan. Datascope was organized in 1964 and is headquartered in Montvale, New Jersey.


MENTOR CORPORATION (MNT)

Mentor Corporation engages in the development, manufacture, and marketing of clinical and consumer healthcare products. The company operates in three segments: Aesthetic and General Surgery, Surgical Urology, and Clinical and Consumer Healthcare. The Aesthetic and General Surgery segment's products include surgically implantable prostheses for plastic and reconstructive surgery, as well as capital equipment and consumables used for soft tissue aspiration or body contouring. The Surgical Urology segment's products include surgically implantable prostheses for the treatment of impotence, surgically implantable incontinence products, urinary care products, and brachytherapy seeds for the treatment of prostate cancer. The Clinical and Consumer Healthcare segment's products include catheters and other products for the management of urinary incontinence and retention. The company sells its products through direct sales force, healthcare dealers, wholesalers, and retail outlets. It sells its products in the United States, Canada, western Europe, central and South America, and the Pacific Rim. Mentor Corporation was founded by Christopher Conway, Eugene Glover, and Thomas Hauser in 1969. The company is headquartered in Santa Barbara, California.


RESMED INC (RMD)

ResMed, Inc., through its subsidiaries, engages in the design, manufacture, and marketing of equipment for the diagnosis and treatment of sleep-disordered breathing and other respiratory disorders, including obstructive sleep apnea. Its products include airflow generators; diagnostic products; mask systems; headgear; and other accessories, including humidifiers, cold passover humidifiers, carry bags, breathing circuits, Twister remote, the Aero-Click connection system, and the AeroFix headgear. The company markets its products through a network of distributors, independent manufacturers' representatives, and direct sales force. ResMed has strategic alliances with Guidant Corporation and MedCath Corporation. The company was founded in 1989 and is based in Poway, California.


DYNATRONICS CORPORATION (DYNT)

Dynatronics Corporation engages in the design, manufacture, marketing, and distribution of physical medicine products and aesthetic products. It offers a line of medical equipment, including therapy devices, medical supplies and soft goods, treatment tables, and rehabilitation equipment. In addition, the company manufactures and distributes a line of aesthetic equipment that consists of aesthetic massage and microdermabrasion devices, as well as provides skin care products. Dynatronics' products are primarily used by physical therapists, chiropractors, sports medicine practitioners, podiatrists, plastic surgeons, dermatologists, aestheticians, and other aesthetic services providers. It distributes its products primarily through a network of independent dealers, direct relationships with certain national accounts, and full-line catalog, as well as through manufacturer representatives and direct sales force in the United States and internationally. Dynatronics was founded in 1983 and is headquartered in Salt Lake City, Utah.


SOMANETICS CORPORATION (SMTS)

Somanetics Corporation engages in the development, manufacture, and marketing of medical devices primarily in the United States. Its INVOS Cerebral Oximeter, a noninvasive patient monitoring system, provides continuous information about changes in the blood oxygen level in the brain. This system is used as monitoring system in hospital care areas, including operating rooms, recovery rooms, ICUs, and emergency rooms. Somanetics also develops and markets the CorRestore system for use in cardiac repair and reconstruction, including heart surgeries called surgical ventricular restoration. The company offers the Cerebral Oximeter to cardiac, cardiovascular and vascular surgeons, neurosurgeons, anesthesiologists, and perfusionists. It sells its devices through direct sales force and independent sales representative firms in the United States, as well as through independent distributors in international markets. Internationally, the company distributes Cerebral Oximeter in 56 countries, including Europe, Canada, and Japan. Somanetics was founded in 1982 and is based in Troy, Michigan.


VARIAN MEDICAL SYSTEMS INC (VAR)

Varian Medical Systems, Inc. engages in the design, manufacture, sale, and service of equipment and software products to treat cancer with radiation. The company operates in two segments, Oncology Systems and X-ray Products. The Oncology Systems segment designs, manufactures, sells, and services hardware and software products for treating cancer with radiation, including linear accelerators, treatment simulation and verification products, information management and treatment planning software, and other accessory products and services. This segment's customers include comprehensive cancer treatment clinics, university research and community hospitals, private and governmental institutions, healthcare agencies, doctors' offices, and cancer care clinics worldwide. The X-ray Products segment manufactures and sells X-ray imaging components and subsystems, such as X-ray tubes for use in computed tomography, scanning, radioscopic/fluoroscopic imaging, mammography, special procedures, and industrial applications; and flat panel imaging products for digital X-ray image capture. This segment's products are sold to original equipment manufacturers and end-users. The company markets its products through independent distributors in North America, Europe, Australia, Asia, and Latin America. Varian Medical Systems was incorporated as Varian Associates, Inc. in 1948 and is based in Palo Alto, California.


LAKELAND INDUSTRIES INC (LAKE)

Lakeland Industries, Inc. engages in the manufacture and sale of a line of safety garments and accessories for the industrial protective clothing market in the United States. Its products include limited use/disposable protective garments for protection from low-risk contaminants or irritants, such as chemicals, pesticides, fertilizers, paint, grease, and dust; chemical protective suits for protection from hazardous or potentially lethal chemical and biological toxins; fire fighting and heat protective apparel for use by fire fighters and other individuals; gloves and arm guards; and reusable woven garments. The company sells its products to safety and mill supply distributors, as well as to governmental agencies and departments through own sales force and independent sales representatives. Lakeland Industries was co-founded by Raymond J. Smith. The company was organized in 1982 and is headquartered in Ronkonkoma, New York.


SYNERON MEDICAL LTD (ELOS)

Syneron Medical, Ltd. engages in the design, development, and marketing of aesthetic medical products to physicians and other practitioners worldwide. The company's products are based on its proprietary electro-optical synergy technology, which uses the synergy between electrical energy and optical energy. Its product line includes Aurora, Galaxy, Pitanga, and Comet, which are used in the treatment of hair removal, rejuvenating the skin's appearance, and acne; Polaris, which is used in the treatment of wrinkles; and Vela, which is used in cellulite treatment. The company sells its products directly to users and through third-party distributors. Syneron Medical was incorporated in 2000 and headquartered in Yokneam Illit, Israel.


NORTHSTAR NEUROSCIENCE INC (NSTR)

Northstar Neuroscience, Inc., a medical device company, focuses on the development and commercialization of neurostimulation therapies for various neurological diseases and disorders. The company is developing a cortical stimulation therapy system called Renova that delivers targeted electrical stimulation to the cortex. Its primary product candidate, Renova-ST, is designed to enhance recovery of hand and arm motor function in patients who have suffered a stroke. The company is also conducting a pivotal trial called EVEREST to evaluate the safety and efficacy of its Renova-ST in conjunction with intensive rehabilitative therapy, in improving hand and arm function in ischemic stroke survivors with chronic upper-extremity hemiparesis. In addition, Northstar Neuroscience is conducting ongoing clinical trials using its proprietary Renova cortical stimulation system for the treatment of various indications, including stroke motor recovery, stroke-related aphasia, tinnitus, and major depressive disorder. The company was founded in 1999. It was formerly known as Vertis Neuroscience, Inc. and changed its name to Northstar Neuroscience, Inc. in 2003. Northstar Neuroscience is headquartered in Seattle, Washington.


IVIVI TECHNOLOGIES INC (II)

Ivivi Technologies, Inc., a medical technology company, engages in the designing, developing, and commercializing electrotherapeutic technologies. Its pulsed electromagnetic field (PEMF) technologies use electric or electromagnetic signals to help relieve pain, swelling, and inflammation and promote healing processes and tissue regeneration. The company utilizes this technology, through patented SofPulse device line of products, which consists of three components: electroceutical signals, signal generator, and applicator. The signal generator produces a specific electroceutical signal that is pulsed through a cable and into the applicator. The applicator transmits the electroceutical signal into the desired area, penetrating medical dressings, casts, coverings, clothing, and virtually all other non-metal materials. Ivivi Technologies products are used for the treatment of acute or chronic wounds, including post surgical wounds; edema and pain following plastic and reconstructive surgery; and pain associated with the inflammatory phase of chronic conditions. It has a strategic alliance with Inamed Medical Products Corporation for distribution. The company was founded in 1989. It was formerly known as AA Northvale Medical Associates, Inc. and changed its name to Ivivi Technologies, Inc. in 2004. The company is headquartered in Northvale, New Jersey.


ROCKWELL MEDICAL TECHNOLOGIES INC (RMTI)

Rockwell Medical Technologies, Inc. engages in manufacturing, selling, and distributing hemodialysis concentrates and other ancillary medical products and supplies used in the treatment of patients with end stage renal disease. The company's products are used to cleanse patients' blood and replace nutrients during the kidney dialysis process. Its hemodialysis concentrates consist of two primary products, acidified dialysate concentrate, also known as acid concentrate, and bicarbonate. Rockwell Medical supplies 3 types of basic series acid concentrate products and 60 different liquid acid concentrate formulations. The company offers approximately 20 bicarbonate products covering the 3 series of generally used bicarbonate dilution ratios. The company provides various ancillary products, including blood tubing, fistula needles, specialized custom kits, dressings, cleaning agents, filtration salts, and other supplies used by hemodialysis providers. Rockwell Medical supplies the products to medical service providers who treat patients with kidney disease in the United States, the Far East, eastern Europe, and Latin America. Rockwell Medical was incorporated in 1996 and is based in Wixom, Michigan.


AMERICAN MEDICAL SYSTEMS HOLDINGS INC (AMMD)

American Medical Systems Holdings, Inc. (AMS) engages in the development and delivery of medical solutions to patients and physicians. The company offers products for erectile restoration, benign prostatic hyperplasia, male urethral stricture, urinary and fecal incontinence, menorrhagia, and pelvic organ prolapse. It provides various solutions, including the Artificial Urinary Sphincter, the In-Fast, SPARC, Monarc, BioArc sling systems, and the Acticon Neosphincter to restore male and female urinary continence and fecal continence, as well as provides treatments for vaginal prolapse and menorrhagia. In addition, AMS offers a range of solutions for erectile restoration and urethral stricture; TherMatrx Dose Optimized therapy for in-office benign prostatic hyperplasia, as well as provides detrusor external sphincter dyssynergia treatment and prostate treatments. The company distributes its products through direct sales force, independent sales representatives, and independent distributors to physician customers, including urologists, gynecologists, and urogynecologists in the United States, Canada, Australia, Brazil, Europe, Europe, and Asia. AMS was founded by Robert Buuck, Gerald Timm, William Bradley, and F. Brantley Scott in 1972. The company is headquartered in Minnetonka, Minnesota.


EDAP TMS S.A (EDAP)

EDAP TMS S.A. engages in the development, production, and marketing of minimally invasive medical devices for urological diseases. It operates in two divisions, High Intensity Focused Ultrasound (HIFU) and Urology Devices and Services (UDS). The HIFU division develops and markets devices for the minimally invasive destruction of certain types of localized tumors using HIFU technology. It develops and markets the Ablatherm, an ultrasound-guided HIFU device for the treatment of organ-confined prostate cancer. In addition, this division leases equipment, as well as offers disposables, spare parts, and maintenance services. The UDS division produces and commercializes medical equipment for the treatment of urinary tract stones using Extra-corporeal Shockwave Lithotripsy. It offers lithotripters that include the Sonolith Praktis and the Sonolith Vision models in the European Union, Japan, Canada, and the United States. In addition, this division leases lithotripters, as well as offers disposables, spare parts, and maintenance services. The company offers its products worldwide through its direct marketing and sales organization, as well as through third-party distributors and agents. EDAP TMS was founded in 1979 and is headquartered in Vaulx-en-Velin, France.


HEALTHTRONICS INC (HTRN)

HealthTronics, Inc. engages in the provision of healthcare services; manufacture of medical devices primarily for the urology community; and manufacture and design of specialty vehicles used for the transport of medical, and broadcast and communications equipment primarily in the United States. It operates in three segments: Urology, Specialty Vehicle Manufacturing, and Medical Device Sales and Service. The Urology segment provides services related to the operation of lithotripters, including scheduling, staffing, training, quality assurance, regulatory compliance; and contracting with payors, hospitals, and surgery centers. These Lithotripters use extracorporeal shock waves to break up kidney stones into small pieces, which can pass naturally through the body's urinary tract. The Specialty Vehicle Manufacturing segment provides manufacturing services and installation, upgrade, refurbishment, and repair of medical equipment for mobile medical service providers, and the mobile broadcast and communication industry. This segment designs, constructs, and engineer mobile trailers, coaches, and special purpose mobile units that transport medical devices, such as magnetic resonance imaging, cardiac catheterization labs, CT scanware, lithotripters and positron emission tomography, and equipment designed for mobile command and control centers, as well as broadcasting and communications applications. The Medical Device Sales and Service segment manufactures, sells, and maintains lithotripters, as well as markets fixed and mobile tables for urological treatments and imaging; and patient handling tables for use by pain management clinics. HealthTronics is headquartered in Austin, Texas.


ASPECT MEDICAL SYSTEMS INC (ASPM)

Aspect Medical Systems, Inc. and its subsidiaries engage in the development, manufacture, and marketing of an anesthesia monitoring system called the BIS system. The company's BIS system provides information that enables clinicians to assess and manage a patient's level of consciousness in the operating room and intensive care settings, and administer the amount of anesthesia needed by each patient. Its customers include anesthesia providers, hospitals, outpatient surgical centers, and individual practitioners in office-based practice. The company markets and sells its products through direct sales force, distributors, and original equipment manufacturers worldwide. Aspect Medical Systems has collaboration with Brain Resource Co., Ltd. in a clinical study that would evaluate brain electrical activity in patients identified with mild cognitive impairment, a memory impairment that often precedes Alzheimer's disease. The company was founded in 1987 and is headquartered in Newton, Massachusetts.


DIGIRAD CORPORATION (DRAD)

Digirad Corporation engages in the development, manufacture, and distribution of solid-state medical imaging products and services for the detection of cardiovascular disease and other medical conditions. The company, through its wholly owned subsidiaries, Digirad Imaging Solutions, Inc. and Digirad Imaging Systems, Inc., offers mobile imaging leasing service, called FlexImaging, which includes an imaging system, certified personnel, required licensure, and other logistics for the performance of nuclear imaging procedures under the supervision of physicians. Digirad sells a line of solid-state gamma cameras and accessories offering general nuclear imaging and specific clinical-application imaging. It markets its products primarily to physician practices and outpatient clinics. The company was founded by Jack Butler in 1985 as San Diego Semiconductor. It changed its name to Aurora Technologies in 1991 and to Digirad Corporation in 1994. The company is headquartered in Poway, California.


CYBERONICS INC (CYBX)

Cyberonics, Inc., a neuromodulation company, engages in the design, development, and commercialization of medical devices for the treatment of epilepsy, depression, and other chronic treatment-resistant disorders using vagus nerve stimulation (VNS) therapy. The VNS Therapy System, an implantable generator, delivers preprogrammed intermittent mild electrical pulses to the vagus nerve in the patient's neck continuously. VNS Therapy is approved for use as an adjunctive therapy in reducing the frequency of seizures in patients with partial onset seizures that are refractory or resistant to antiepileptic drugs and as a long-term adjunctive treatment for patients 18 years of age or older with chronic or recurrent treatment-resistant depression in a major depressive episode that has not responded to at least 4 adequate antidepressant treatments. VNS Therapy is at various levels of investigational clinical study as a treatment for anxiety disorders, Alzheimer's disease, chronic headache/migraine, and bulimia. The company sells and markets its products through direct sales force and distributors in the United States, Canada, Mexico, Europe, Asia, South Africa, and Australia. Cyberonics was co-founded by Jacob Zabara in 1987 and is headquartered in Houston, Texas.


CRITICARE SYSTEMS INC (CMD)

Criticare Systems, Inc. engages in the design, manufacture, and marketing of vital signs and gas monitoring instruments, and related noninvasive sensors used to monitor patients in various healthcare environments worldwide. It offers a line of patient monitors for monitoring oxygen saturation, carbon dioxide, and anesthetic agents. These patient monitors combine one or more of its patented or other proprietary technologies with monitoring technologies that provide electrocardiogram, invasive and noninvasive blood pressures, temperature, heart rate, and respiration rate. In addition, the company's VitalView telemetry system allows one nurse to monitor up to eight patients simultaneously from a central location. Its monitors incorporate adjustable visual and audible alarms to provide patient-specific warnings of critical conditions, as well as display information graphically and numerically. It also develops and markets modules and stand-alone monitors for blood pressure and anesthetic gases to original equipment manufacturers. The company sells its products to surgery centers, dental and physician offices, and nursing homes through its sales force and dealer network. Criticare Systems was founded in 1984 and is headquartered in Waukesha, Wisconsin.


SYNERGETICS USA INC (SURG)

Synergetics USA, Inc. engages in the design, manufacture, and marketing of precision-engineered, microsurgical instruments, and capital equipment and devices primarily for use in vitreoretinal surgery and neurosurgical applications worldwide. Its products are designed to support micro or minimally invasive surgical procedures. The company designs and manufactures disposable and nondisposable supplies and accessories for use with its products. It also develops various microsurgical instruments, including scissors, retractors, cannulas, forceps, and other reusable and disposable surgical instruments for ophthalmic and vitreoretinal surgical market. The company's neurosurgical product line includes Omni ultrasonic aspirator used for tumor removal, bone removal, and resection; and precision neurosurgical instruments. It offers a lesion generator, which is used for minimally invasive pain treatment. In addition, the company manufactures and sells bipolar electrosurgical generators and other generators based on its DualWave technology, as well as complementary instrumentation and disposable products for use in neurosurgery, spine surgery, pain control, and dental applications. Its Bident Bipolar Tissue Management System allows dentists to work in direct contact with metal implants, nerves, bone, and blood vessels, eliminating collateral tissue damage from current spread and heat buildup. Synergetics sells its products to hospitals, clinics, and surgeons through distributors and independent sales representatives. The company was founded in 1991 and is headquartered in O'Fallon, Missouri.


PHOTOMEDEX INC (PHMD)

PhotoMedex, Inc. develops excimer laser and fiber-optic systems for treatment of cardiovascular and vascular disease, and for dermatological applications, such as psoriasis. The company develops excimer laser under the brand name XTRAC, which is used for the treatment of psoriasis, vitiligo, atopic dermatitis, and leukoderma. Its surgical products include Contact Laser, a specialty surgical instrument that can cut, coagulate, or vaporize tissue, as well as Contact Laser probe and scalpel surface treatments, which provide the ability to alter selectively the temperature profile of tissue. The company also offers a range of laser services, including urology, gynecology, orthopedics, and general surgery. It offers products used in surgery in venues, such as hospitals, surgical centers, and doctors offices. The company markets its XTRAC system through independent distributors primarily in the United States, Europe, Australia, and South Africa. PhotoMedex is headquartered in Radnor, Pennsylvania.


SIGNALIFE INC (SGN)

Signalife, Inc. engages in the research, development, and marketing of medical devices in the United States. Its medical devices are used to monitor and measure physiological signals in order to detect diseases that impact an individual's health. The company offers Fidelity 100 Monitor System, an integrated system in which its Model 100 Module collects, processes, and amplifies electrocardiogram signals from the patient through a set of 12 electrode lead sets provided with the system, and then wirelessly transmits that signal to a nearby personal computer provided with the system. In addition, its ambulatory heart monitor, Holter Monitor, enables the patient's heart to be continuously monitored over a period, while the patient carries out his or her daily activities. Further, Signalife's products in development include Fidelity 200 Event Recording System, a non-prescription over-the-counter event recording system; Cardiac Vest, a lightweight, close-fitting vest or undergarment made of stretchable material in which the electrodes are stitched into the fabric; and Intracardiac Monitor that applies its proprietary physiological signal acquisition and amplification technology to read intracardiac signals procured from intracardiac catheter products. The company was incorporated in 1987 as Mt. Olympus Enterprises, Inc. and changed its name to Recom Managed Systems, Inc. in 1998. Further, it changed its name to Signalife, Inc. in 2005. The company is based in Greenville, South Carolina. Signalife, Inc. is a subsidiary of ARC Finance Group, LLC.


PALOMAR MEDICAL TECHNOLOGIES INC (PMTI)

Palomar Medical Technologies, Inc. engages in the research, development, manufacturing, and distribution of light based systems for hair removal and other cosmetic treatments. It offers products based on technologies that include hair removal, removal of benign pigmented lesions, such as age and sun spots; tattoo removal; acne treatment; wrinkle removal; pseudofolliculitis barbae or pfb treatment; treatment of red pigmentation in hypertrophic and keloid scars; treatment of verrucae, skin tags, seborrheic keratosis; deep tissue heating for relief of muscle and joint pain; noninvasive treatment of facial and leg veins and other benign vascular lesions, such as rosacea, spider veins, port wine stains and hemangiomas; and other skin treatments. The company operates in the United States, Japan, Canada, Europe, Australia, Asia/Pacific, and South and Central America. Palomar was organized in 1987 and is headquartered in Burlington, Massachusetts.


ATS MEDICAL INC (ATSI)

ATS Medical, Inc. engages in the development, manufacture, and marketing of medical devices, primarily cardiovascular surgery products. It operates in the mechanical bileaflet portion of the replacement heart valve and in the surgical treatment of atrial fibrillation markets. The company also develops autotransfusion products. ATS Medical's primary product includes ATS Open Pivot Heart Valve, which is designed to address factors that contribute to thrombogenesis in mechanical valves and enable hemodynamic performance. The company also markets surgical cryotherapy products for the ablation of cardiac arrhythmias in the United States and internationally. It sells its products through direct sales organizations in the United States and France, as well as through an independent distribution network in other international markets. ATS Medical was founded in 1987 and is based in Minneapolis, Minnesota.


THERMOGENESIS CORP (KOOL)

Thermogenesis Corp. engages in the design, manufacture, and distribution of blood processing devices and single-use sterile blood processing disposables that enable the manufacture of therapeutic biological products. Its therapeutic products include hematopoietic stem cells from placental/cord blood for bone marrow rescue transplants; blood protein surgical sealants to arrest surgical bleeding or bond excised tissue; and platelet gels to accelerate the healing of damaged bones and chronic dermal wounds. The company's products portfolio comprises BioArchive System, a robotic liquid nitrogen storage system with integrated controlled rate freezer process to cryopreserve and archive units of cord blood stem cells in liquid nitrogen; BioArchive accessories and sterile single use disposables, such as over wrap bags, sealers, expressers, a manual retrieval device, protective storage canisters, processing bags, and freezing bags; ThermoLine Ultra-Rapid Plasma Thawers used for homogeneous thawing of frozen red blood cells or fresh frozen plasma before their transfusion; Ultra-Rapid Plasma Freezers that optimize plasma freezing through liquid heat transfer and uniform freezing technologies; AutoXpress System, designed to provide cord blood banks a semiautomated means of collecting mono-nuclear cells from cord blood into a fixed volume within a closed sterile bag; CryoSeal FS System, which produces fibrin sealant components from a single unit of autologous or single donor plasma in about one hour; and thrombin processing device, a sterile single use disposable that can produce approximately 8 ml of activated thrombin from an 11 ml aliquot of the patient's blood or blood plasma. The company markets its products through direct sales force and independent distributors to hospitals and blood banks located in the United States, Europe, Japan, Asia-Pacific, Canada, and Latin America. ThermoGenesis was founded in 1985 and is based in Rancho Cordova, California.


CANDELA CORPORATION (CLZR)

Candela Corporation engages in the research, development, manufacture, marketing, sale, and servicing of lasers and light-based products used to perform aesthetic and cosmetic procedures worldwide. Its product line includes GentleLASE family of lasers for the treatment of unwanted hair and for the treatment of vascular lesions, pigmented lesions, and wrinkles; Vbeam for the treatment of vascular lesions, wrinkles, psoriasis, and other conditions; ALEXLAZR for the treatment of pigmented lesions and tattoos; Smoothbeam diode laser for nonablative dermal remodeling of wrinkles, and the treatment of acne and acne scars; C-beam pulsed dye laser for treatment of psoriasis and surgical scars; and Ellipse Intense Pulsed Light system for the improvement of sun-damaged skin by photo rejuvenation through removal of both vascular and dyspigmentation. The company sells its products directly and through a network of distributors to plastic and cosmetic surgeons; dermatologists; general practitioners; and certain specialists, including obstetricians, gynecologists, and general and vascular surgeons. Candela Corporation was founded in 1969 and is headquartered in Wayland, Massachusetts.


UROLOGIX INC (ULGX)

Urologix, Inc. engages in the design, development, manufacture, and marketing of medical devices for the treatment of benign prostatic hyperplasia (BPH). It markets its products under Targis and Prostatron names. BPH is a disease that causes adverse changes in urinary voiding patterns in men. The company offers nonsurgical and catheter-based therapies that use a proprietary cooled microwave technology. Urologix is based in Minneapolis, Minnesota.


ALPHA PRO TECH LTD (APT)

Alpha Pro Tech, Ltd. engages in the development, manufacture, and marketing of disposable protective apparel and infection control products primarily in the United States. It also manufactures and distributes medical bed pads and accessories, as well as pet beds. The company operates in four segments: Disposable Protective Apparel, Infection Control, Extended Care, and Engineered Products. The Disposable Protective Apparel segment produces disposable protective apparel, which include shoecovers, bouffant caps, gowns, frocks, coveralls, and lab coats. The Infection Control segment offers face masks and eye shields. The Extended Care segment offers extended care products, such as medical bed pads, pet beds and pet toy accessories, wheelchair covers, geriatric chair surfaces, operating room table surfaces, and pediatric surfaces. The Engineered Products segment provides a line of construction weatherization products and paint with antimicrobials. Its construction weatherization products consist of building wrap and a synthetic roof underlayment. Its line of paint with antimicrobials is designed to inhibit growth of bacteria, fungi, and algae on the painted surfaces in hospitals, surgical rooms, and cleanrooms and associated controlled environments. Alpha Pro Tech offers its products in the industrial, cleanroom, pharmaceutical, medical and dental, and extended care markets. The company sells its products primarily through a network of independent distributors. Alpha Pro Tech was founded in 1983 and is headquartered in Markham, Canada.


ARRHYTHMIA RESEARCH TECHNOLOGY INC (HRT)

Arrhythmia Research Technology, Inc. (ART) engages in the development and licensing of medical software that acquires data and analyzes electrical impulses of the heart to detect and aid in the treatment of potentially lethal arrhythmias. Its products consist of Predictor 7 software, which is a Windows compatible version of Arrhythmia Research Technology's analytical program for the detection of late potentials. The company's customers include research institutions, hospitals, and clinics. Arrhythmia, through its wholly owned subsidiary, Micron Products, Inc., manufactures and distributes silver plated and nonsilver plated conductive resin sensors, and metal snap fasteners used in the manufacture of disposable integrated electrodes constituting a part of electrocardiographic diagnostic and monitoring instruments. It also manufactures and leases electrode assembly machines to its sensor and snap customers. The company markets its products through licensing with original equipment manufacturers. Arrhythmia was founded in 1981 and is based in Fitchburg, Massachusetts.


IRIDEX CORPORATION (IRIX)

IRIDEX Corporation engages in the development, manufacture, marketing, and sale of medical laser systems for the ophthalmic and aesthetic markets worldwide. The company provides semiconductor-based laser systems used to treat eye diseases in ophthalmology and skin conditions in dermatology. IRIDEX operates in two segments, Ophthalmology and Dermatology. The Ophthalmology segment develops, manufactures, and markets medical devices for the treatment of eye diseases, including the causes of irreversible blindness, age-related macular degeneration, diabetic retinopathy, and glaucoma. Its ophthalmology laser systems include IRIS Medical IQ810 Laser System, the OcuLight Symphony, OcuLight SL, OcuLight SLx, OcuLight GL, and OcuLight GLx laser photocoagulation systems used for ophthalmic applications primarily in hospitals, clinics, and doctors' offices. The Dermatology segment develops, manufactures, and markets medical devices to treat skin conditions, primarily vascular and pigmented lesions and remove unwanted hair. Its dermatology laser systems include the DioLite 532, the Apex 800, and the VariLite Dual Wavelength Laser systems primarily used in the practitioners' offices. The company sells its products to general ophthalmologists, as well as those specializing in retina, glaucoma and pediatrics, dermatologists, and plastic surgeons. Its other customers include research and teaching hospitals, government installations, surgi-centers, and hospitals. The company markets its products through direct sale force and distributors in the United States, as well as in Europe and the Asia/Pacific Rim region. IRIDEX Corporation was founded in 1989 under the name IRIS Medical Instruments, Inc. and changed its name to IRIDEX Corporation in 1996. The company is headquartered in Mountain View, California.


QMED INC (QMED)

QMed, Inc., through its wholly owned subsidiary, Interactive Heart Management Corp., provides health care information and communication services to health plans, governments, and private companies. These services include ohms|cvd (online health management system for cardiovascular disease), which is an integrated cardiovascular disease management system. ohms|cvd includes related systems that assist in the management of cardiovascular conditions, including coronary artery disease, stroke, congestive heart failure, hypertension, hyperlipidemia, and cardiovascular complications of diabetes. These systems are designed to aid primary health care physicians in the use of evidence based' medical management for patients with these conditions, as well as those at high risk of developing these conditions. As of November 30, 2004, the company had contracts to provide these services to 13 licensed health plans in 11 states covering approximately 1.1 million health plan members. In addition, the company produces, sells, and supports a line of ischemic heart monitors and a system that analyzes heart rate variability under the name, Monitor One nDx. QMed was founded in 1983 and is headquartered in Eatontown, New Jersey.


FONAR CORPORATION (FONR)

FONAR Corporation engages in the research, development, production, and marketing of medical scanning equipment, which utilizes magnetic resonance imaging technology (MRI) for the detection and diagnosis of human diseases. Its principal products include Stand-Up/Upright MRI, which allows patients to be scanned in a fully weight bearing condition, such as standing, sitting, or bending in any position that causes symptoms; and FONAR 360, a room-size recumbent scanner that optimizes openness while facilitating physician access to the patient. The company also provides management services to physician's practices and other medical providers, including diagnostic imaging centers and ancillary services. These services include development; administration; leasing of office space; facilities and medical equipment; provision of supplies; staffing and supervision of nonmedical personnel; legal services; accounting, billing, and collection; and the development and implementation of practice growth and marketing strategies. The company offers its products and services primarily to private scanning centers and hospitals in the United States, Europe, and the Middle East. FONAR Corporation was formed in 1978 and is headquartered in Melville, New York.


RESTORE MEDICAL INC (REST)

Restore Medical, Inc. engages in the development, manufacture, and marketing of Pillar palatal implant systems. The company's Pillar palatal implant system is used for the treatment of soft palate components of sleeps disordered breathing, including obstructive sleep apnea and snoring. The company markets and sells its products to otolaryngologists, including ear, nose, and throat physicians; and oral maxillofacial surgeons in North America, South America, Asia Pacific, Europe, the Middle East, and South Africa. The company was founded in 1999 and is headquartered in St. Paul, Minnesota.